Toward Smart Healthcare Ram D. Sriram Chief, Software and Systems - - PowerPoint PPT Presentation
Toward Smart Healthcare Ram D. Sriram Chief, Software and Systems Division URL: http://www.nist.gov/itl/ssd/ sriram@nist.gov Information Technology Laboratory, National Institute of Standards and Technology Levels of Biological Information
Information Technology Laboratory, National Institute of Standards and Technology
Information Technology Laboratory, National Institute of Standards and Technology
Hood
Ecologies Societies/Populations Individuals Organs Tissues Cells Protein and gene networks Protein interaction networks Protein mRNA DNA
Information Technology Laboratory, National Institute of Standards and Technology “Genomics” “Transcriptomics” “Proteomics” “Metabolomics” “Cellomics”
Lucasio
Information Technology Laboratory, National Institute of Standards and Technology
2D gel electrophoresis 1975 1990 ESI & MALDI 1980 Gene cloning Sequencing 1994 Complex mixture analysis LC-MS(/MS) Chip-based approaches 1996 1944 DNA Genetic material 1953 DNA structure 1980 1990 2000 1960 1970 Recombinant technology Automated sequencing High-throughput at Genome scale, „data rich‟ biology 1995 Haemophilus influenzae first genome sequenced 2001 Human genome sequenced 1931 Non-equilibrium thermodynamics 1952 Self-
1957 1980 1990 1970 Feedback regulation In metabolism Analog simulation, bioenergetics, lac operon Large-scale simulators
structures, energy coupling MAC and BST 2000 „data poor‟ in silico biology, models of viruses, red blood cell Genome-scale models and analysis, large-scale kinetic models
Proteomics Genomics BioAnalysi s Computer Science
Systems Biology (Medicine)
1936 Turing machines 1956 Artificial Intelligence 1960 Programming Languages 1980 Commercial Database 1974 Internet Bioinformatics mid 1980 1990 Major advances in AI 2000
Engineering
1943 Finite element analysis 1950 Systems engineering 1960 Cybernetics Integrated Circuits 1970 1980 Computational FEM Mainframe Computers 1990 VLSI CAD/ CAD/ Geometry Large scale product Process simulation PDM/Knowl. based Engineering 2000 MEMS Nano PLM PC’S Supercomputers Multi-scale Domain Simulation
Bernhard O. Palsson
Information Technology Laboratory, National Institute of Standards and Technology Future Health Vision Evidence-Based Healthcare Continuum of Care Advances in Healthcare Practice Disease Management
Courtesy: Jack Corley
Advances in Healthcare Technology
Human Genome Project Pharmaceuticals and Nutraceuticals Medical Devices mPCD
Networking Communications and Imaging Advances in Computing, Imaging, and Information Technology Speed and Storage
Internet-based Software
Courtesy: Fred Hosea, Ph.D. Program Director Clinical Technology fred.w.hosea@kp.org
27 Periodic Cart READINESS CHECK (W/LAN access reqd) 42 1 Users are trained on service model and contact # 4 SSSSmart Healthcare
Information Technology Laboratory, National Institute of Standards and Technology
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Plan Build Run Lifecycle Management Infrastructure
20th Century Medicine: Stand-alone Devices
ENTERPRISE STRATEGY
21st Century Medicine: Net-New Lifecycle Requirements
fred.w.hosea@kp.org