Thiarubrine A antiviral antifungal ( Candida albicans ) - PowerPoint PPT Presentation

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Naturally occurring alkynes (+)-Laurencin isolated from red algae Laurencia glandulifera Burton, J.W.; Clark, J.S.; Derrer, S.; Stork, TC.; Bendall, J.G.; Holmes, AB.; J. Am. Chem. Soc. 1997 , 119 , 7483. Thiarubrine A antiviral

Naturally occurring alkynes (+)-Laurencin isolated from red algae Laurencia glandulifera Burton, J.W.; Clark, J.S.; Derrer, S.; Stork, TC.; Bendall, J.G.; Holmes, AB.; J. Am. Chem. Soc. 1997 , 119 , 7483.
Thiarubrine A � antiviral � antifungal ( Candida albicans ) � antibacterial Masato Koreeda, M.; Yang, W. J. Am. Chem. Soc. 1994 , 116 , 10793.
Enediynes Share a common ( Z )-1,5-diyn-3-ene moiety � Target minor groove or AT-rich DNA & intercalate � “Triggered” by an extended conjugate addition � Result of pulling trigger is a diradical � Diradical leads to SS and DS DNA cuts � NCZ diradical Nicolaou, K.C.; Dai, W.-M. Angew. Chem. Int. Ed. Engl. 1991 , 30 , 1387-1530.

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