Time-Kill Kinetics of the Novel Echinocandin CD101 for Azole- Susceptible and -Resistant Candida
- spp. at pH 4 in Vagina-Simulative
Time-Kill Kinetics of the Novel Echinocandin CD101 for Azole- - - PowerPoint PPT Presentation
Time-Kill Kinetics of the Novel Echinocandin CD101 for Azole- Susceptible and -Resistant Candida spp. at pH 4 in Vagina-Simulative Medium Jeff Locke, PhD Amanda Almaguer, BSc Ken Bartizal, PhD August 13, 2016 IDSOG Annual Meeting
These slides and the accompanying oral presentation (the “Presentation”) contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. Such statements include, but are not limited to, statements regarding the effectiveness, safety, dosing, potential to treat infections and other attributes of CD101 topical, as well as related information regarding the effectiveness and treatment protocols for competitive therapies. Risks that contribute to the uncertain nature of the forward-looking statements include: the success and timing of Cidara’s preclinical studies, clinical trials and other research and development activities; regulatory developments in the United States and foreign countries; changes in Cidara’s plans to develop and commercialize its product candidates; Cidara’s ability to obtain additional financing; Cidara’s ability to
management personnel. These and other risks and uncertainties are described more fully in Cidara’s Form 10-K and Form 10-Q, each as most recently filed with the United States Securities and Exchange Commission (SEC), under the heading “Risk Factors.” All forward-looking statements contained in the Presentation speak only as of the date on which they were made. Cidara undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made.
*JMI 2015 SENTRY international surveillance study data
C o n tro l 0 .0 6 2 5 0 .2 5 1 1 0 2 0 3 0 4 0 5 0
C D 1 0 1 C o n c . (u g /m l) B io film T h ic k n e s s (µ m )
C o n tro l 0 .0 6 2 5 0 .2 5 1 0 .0 0 .1 0 .2 0 .3 0 .4
C D 1 0 1 C o n c . (u g /m l) X T T O D 4 9 2 n m
CD101 (µg/mL) CD101 (µg/mL)
(M. Ghannoum, unpublished data, 2016)
* VVC clinical isolate
1Moosa MY, Sobel JD, Elhalis H, Du W, Akins RA. “Fungicidal activity of fluconazole against Candida albicans in a synthetic vagina-simulative medium”
*CLSI MIC value of 32 µg/mL derived in this study is characterized as “susceptible-dose dependent” per CLSI interpretive criteria.
*CLSI MIC value of 32 µg/mL derived in this study is characterized as “susceptible-dose dependent” per CLSI interpretive criteria.
*CLSI MIC value of 32 µg/mL derived in this study is characterized as “susceptible-dose dependent” per CLSI interpretive criteria.
1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 tim e (h ) C F U /m L
1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . a lb ic a n s A T C C 4 4 8 5 8
tim e (h ) C F U /m L 1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
T E R - C . a lb ic a n s A T C C 4 4 8 5 8
tim e (h ) C F U /m L
1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . a lb ic a n s D P L 0 0 1
tim e (h ) C F U /m L 1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . a lb ic a n s R 3 5 7
tim e (h ) C F U /m L
CD101 - ATCC 44858 TER - ATCC 44858 CD101 – DPL001 CD101 – R357
1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . a lb ic a n s A T C C 4 4 8 5 8
tim e (h ) C F U /m L 1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
T E R - C . a lb ic a n s A T C C 4 4 8 5 8
tim e (h ) C F U /m L
1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . a lb ic a n s D P L 0 0 1
tim e (h ) C F U /m L 1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . a lb ic a n s R 3 5 7
tim e (h ) C F U /m L
CD101 - ATCC 44858 TER - ATCC 44858 CD101 – DPL001 CD101 – R357
1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . a lb ic a n s A T C C 4 4 8 5 8
tim e (h ) C F U /m L 1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
T E R - C . a lb ic a n s A T C C 4 4 8 5 8
tim e (h ) C F U /m L
1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . a lb ic a n s D P L 0 0 1
tim e (h ) C F U /m L 1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . a lb ic a n s R 3 5 7
tim e (h ) C F U /m L
CD101 - ATCC 44858 TER - ATCC 44858 CD101 – DPL001 CD101 – R357
1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . g la b ra ta C G 0 1
tim e (h ) C F U /m L 1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
T E R - C . g la b ra ta C G 0 1
tim e (h ) C F U /m L 1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . g la b ra ta A T C C 2 0 0 9 1 8
tim e (h ) C F U /m L 1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . g la b ra ta M M X 7 0 7 0
tim e (h ) C F U /m L
CD101 – CG01 TER – CG01 CD101 – ATCC 200918 CD101 – MMX 7070
1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . g la b ra ta C G 0 1
tim e (h ) C F U /m L 1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
T E R - C . g la b ra ta C G 0 1
tim e (h ) C F U /m L 1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . g la b ra ta A T C C 2 0 0 9 1 8
tim e (h ) C F U /m L 1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . g la b ra ta M M X 7 0 7 0
tim e (h ) C F U /m L
CD101 – CG01 TER – CG01 CD101 – ATCC 200918 CD101 – MMX 7070
1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . tro p ic a lis C T 0 2
tim e (h ) C F U /m L 1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
T E R - C . tro p ic a lis C T 0 2
tim e (h ) C F U /m L 1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . tro p ic a lis M M X 7 2 5 5
tim e (h ) C F U /m L 1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . tro p ic a lis M M X 7 5 2 5
tim e (h ) C F U /m L
CD101 – CT02 TER – CT02 CD101 – MMX 7255 CD101 – MMX 7525
1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . tro p ic a lis C T 0 2
tim e (h ) C F U /m L 1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
T E R - C . tro p ic a lis C T 0 2
tim e (h ) C F U /m L 1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . tro p ic a lis M M X 7 2 5 5
tim e (h ) C F U /m L 1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . tro p ic a lis M M X 7 5 2 5
tim e (h ) C F U /m L
CD101 – CT02 TER – CT02 CD101 – MMX 7255 CD101 – MMX 7525
1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . p a ra p s ilo s is C P 0 2
tim e (h ) C F U /m L 1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
T E R - C . p a ra p s ilo s is C P 0 2
tim e (h ) C F U /m L 1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . p a ra p s ilo s is C P 0 1
tim e (h ) C F U /m L 1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . p a ra p s ilo s is M M X 7 3 7 0
tim e (h ) C F U /m L
CD101 – CP02 TER – CP02 CD101 – CP01 CD101 – MMX 7370
1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . p a ra p s ilo s is C P 0 2
tim e (h ) C F U /m L 1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
T E R - C . p a ra p s ilo s is C P 0 2
tim e (h ) C F U /m L 1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . p a ra p s ilo s is C P 0 1
tim e (h ) C F U /m L 1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . p a ra p s ilo s is M M X 7 3 7 0
tim e (h ) C F U /m L
CD101 – CP02 TER – CP02 CD101 – CP01 CD101 – MMX 7370
1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . k ru s e i A T C C 6 2 5 8
tim e (h ) C F U /m L
1 2 2 4 3 6 4 8 6 0 7 2 1 0 1 1 0 2 1 0 3 1 0 4 1 0 5 1 0 6 1 0 7 1 0 8 1 0 9
C D 1 0 1 - C . k ru s e i A T C C 1 4 2 4 3
tim e (h ) C F U /m L
CD101 – ATCC 6258 CD101 – ATCC 14243