The Left Atrial Appendage Closure by Surgery study (LAACS) Authors - PowerPoint PPT Presentation

Oct 12, 2022 •285 likes •357 views

Study title The Left Atrial Appendage Closure by Surgery study (LAACS) Authors Jesper Park-Hansen, Susanne Holme, Akhmadjon Imrukhamedov, Christian L. Carranza, Anders M. Greve, Gina Al-Farra, Robert GC Riis, Brian Nilsson, Johan Clausen, Anne

Study title The Left Atrial Appendage Closure by Surgery study (LAACS) Authors Jesper Park-Hansen, Susanne Holme, Akhmadjon Imrukhamedov, Christian L. Carranza, Anders M. Greve, Gina Al-Farra, Robert GC Riis, Brian Nilsson, Johan Clausen, Anne Nørskov, Christina Kruuse, Eigill Rostrup and Helena Dominguez. Disclosures - None
Declaration of Interest • No conflicts of interest
Background • Atrial fibrillation (AFIB) occurs in 30-67 % heart surgery Rader. Am Heart J. 2010 Lahtinen. Ann Thorac Surg, 2004 • Stroke occurs in 1-3% of all CABG during the 1 st year Almasssi. Ann Surg, 1997 • Risk of stroke is at least 4% per year for most heart-operated Crystal Circulation. 2002 patients with AFIB ( according to their CHADS-score ) Mack MJ JACC 2013 • Left atrial appendage closure with device showed promising results. • Surgical LAA closure lacked evidence.
Purpose and key points about methods • Does Left Atrial Appendage Closure on occasion to open heart surgery protect the brain against cerebral ischemic events? • Randomized surgical LAA closure regardless og previous atrial fibrillation (AF) diagnosis. – (high risk of AF and stroke following surgery) and all types of open heart surgeries • Closure with ligation using double closure with pursestring closure and single running suture • Combined endpoint – Clinical stroke/TIA or new SCI in time following surgery • Including Silent Cerebral Infarcts as endpoint as a precursor of larger stroke • Follow-up up to 6 years (mean 3.7 years)
Results • 205 enrolled, 187 randomized, 141 operated per-protocol • Intention to treat (n=187): 14 (open) vs 5 (closed) ischemic cerebral events (p = 0.02) • Per-protocol (n=141): 14 (open) vs 4 (closed) ischemic cerebral events (p = 0.04) • Secondary endpoint, (stroke/TIA only) 8 vs 3 (p = 0.07) and 8 vs 2 (p = 0.09) • 9/14 events occured 1 year after follow up, indicating long term effect • No adverse events related to LAA closure
Conclusion It seems as if surgical left atrial appendage closure on occasion to open heart surgery protects against cerebral ischemic events This is the first randomized study of surgical left atrial appendage closure indicating a long term protective effect.

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