The Advancement of Team Science and the Role of Stakeholders in - - PowerPoint PPT Presentation

The Advancement of Team Science and the Role of Stakeholders in Clinical and Translational Science

Presented by: Elaine A. Borawski, PhD Community and Collaboration Component Clinical and Translational Science Collaborative

C&C Team Present:

Anna Matos MPH, Meredith Goodwin PhD, Briana McIntosh MPH, Rachel Gardenhire MS

OVERVIEW

• CTSC and Community and Collaboration Component
• Translational Science
• Team Science
• Stakeholders – What are they? Who are they?
• Aims and Activities of Community and Collaboration

WHAT IS THE CTSA?

• CTSA – Clinical and Translational Science Award. Started in 2005.
• Funded by the NCATS (National Center for Advancing Translational

Sciences – part of NIH).

• Provides resources to research institutions to build infrastructure

and support for clinical and translational research.

• Why was this needed?

– So few scientific findings are disseminated beyond the walls of academia and even fewer are translated into practices that can/will improve health.

HISTORY OF THE CTSC IN CLEVELAND

• NIH recognized a need to streamline research systems and

encourage cross-institution collaboration with broad-based, innovative interdisciplinary teams.

• CTSA is the award, we are the Clinical and Translational Science

Collaborative (CTSC)

• The Cleveland CTSC (for Collaborative) consists of CWRU and four

health systems: University Hospital, MetroHealth, Cleveland Clinic and the VA.

• Initially awarded in 2007, currently in Year 2 of our third 5-year

funding cycle.

GOAL OF THE CLEVELAND CTSC

To utilize the power of the multi-institutional collaborative:

• to ensure rigorous and innovative training of the clinical and

translational workforce,

• to accelerate the translation of discoveries to patients and

communities; and,

• to improve the health of Cleveland and provide scalable models for
• ther locations throughout the nation.

CTSC RESOURCES TO SUPPORT C/T RESEARCH

RESOURCES TO SUPPORT CLINICAL AND TRANSLATIONAL RESEARCH

INFORMATICS

RESEARCH METHODS

COMMUNITY AND COLLABORATION

HUB RESEARCH CAPACITY TRANSLATIONAL ENDEAVORS NETWORK CAPACITY

“Big data”, EHR data, tools to collect, analyze and visualize data Trial Innovation Network; collaborative research with other CTSA hubs across the country. Biostatistics, Epidemiology and Research Design (BERD) and Regulatory Knowledge and Support Study recruitment, assessments, management, and Integrating Special Populations Workforce development and pilot grant funding

KL2 Scholars TL1 Scholars

TRAINING PROGRAMS Promote collaboration through team science, with intentional stakeholder engagement

Purpose of the Community and Collaboration Component (2018-2023)

Promote collaboration through team science, with intentional stakeholder engagement

COMMUNITY AND COLLABORATION TEAM

Elaine Borawski Kurt Stange Mark Chance Shirley Moore Darcy Freedman Heidi Gullett

Anne DeChant Briana McIntosh Meredith Goodwin Anna Thornton Matos Rachel Gardenhire

THE TRANSLATIONAL SCIENCE CONTINUUM

SOURCE: Institute of Medicine. 2013. The CTSA Program at NIH: Opportunities for Advancing Clinical and Translational Research. Washington, DC: The National Academies Press.

DEFINING TRANSLATION IN 2019

• Translation is “the process of turning
• bservations in the laboratory, clinic, and

community into interventions that improve the health of individuals and populations – from diagnostics and therapeutics to medical procedures and behavioral interventions.”

• -NIH National Center for Advancing Translational Sciences (NCATS)

COMMUNITY….REDEFINED

The term community includes all stakeholders connected to clinical and translational research. Communities may include but are not limited to non-profit or industry entities engaged in translational research, and might include disease advocacy groups, local health providers, community-based organizations, and other national or local communities.

• -NIH National Center for Advancing Translational Sciences (NCATS)

WHAT (AND WHOM) IS A STAKEHOLDER

• Stakeholder is an independent, engaged, individual or

group who has a stake in the outcome, and whose input could greatly enhance the research endeavor.

• Type of stakeholder may vary depending on the focus of

the problem, the type of research conducted, and the composite and orientation of the investigative team.

WHY STAKEHOLDER ENGAGEMENT IS IMPORTANT KNOWLEDGE TO ACTION (K2A) FRAMEWORK

Where stakeholders/ practitioners mostly spend their time Where researchers mostly spend their time

WHY STAKEHOLDER ENGAGEMENT IS IMPORTANT KNOWLEDGE TO ACTION (K2A) FRAMEWORK

KNOWLEDGE TO ACTION (K2A) FRAMEWORK

Products:

• Pubs and Reports
• Actionable interventions:

drugs, devices, programs, protocols, guidelines, toolkits

While stakeholder engagement may seem challenging, team science is easy and natural…

RIGHT??

WHAT IS A SCIENTIFIC RESEARCH TEAM?

Level of Interaction and Integration LOW HIGH

Investigator-Initiated Research Investigator works on a scientific program – largely

• n his or her own.

Research Collaboration

• Group works on a scientific problem,

each bringing some expertise to the problem.

• Each member works on a separate

part, which are integrated at the end.

• The interaction of the lead investigators

varies from limited to frequent with regard to data sharing or brainstorming. Integrated Research Team

• Team works on a research problem

with each member bringing specific expertise to the table.

• There are regular meetings and

discussions of the team’s overall goals,

• bjectives of the individuals on the

team, data sharing, and next steps.

• One person takes the lead while other

members have key leadership roles in achieving the goal.

….think of it as a continuum…..

SOURCE: Bennett, L. M., & Gadlin, H. (2012). Collaboration and team science: from theory to practice. Journal of Investigative Medicine, 60(5), 768-775.

WHAT IS TEAM SCIENCE?

Collaboration Interdisciplinarity

TEAM SCIENCE

“…a collaborative effort to address a scientific challenge that leverages the strengths and expertise of professionals trained in different fields” – National Cancer Institute

THE VALUE AND POTENTIAL OF TEAMS

Disis, ML, Slattery, JT. Science Translational Medicine 10 Mar 2010: Vol. 2, Issue 22

IMPACT OF TEAMS

Studies of 19.9 million research articles over 5 decades as recorded in the Web of Science database, and an additional 2.1 million patent records from 1975-2005 found three important facts:

• 1. For virtually all fields, research is increasingly done in teams.
• 2. Teams typically produce more highly cited research than individuals do

(excluding self-citations), and this team advantage is increasing.

• 3. Teams now produce the exceptionally high impact research, even where that

distinction was once the domain of solo authors.

Sources: Wuchty, Jones, and Uzzi, 2007

PRODUCTIVITY IN TEAM SCIENCE

• Comparison of publications

between transdisciplinary science teams with traditional investigator- initiated research grants (R01)

• Centers initially produced

fewer publications, gap eliminated by year 4.

* From Hall et all Am J Prev Med 2012; 42(2):157-163

Cell/Animal Laboratory Patients Clinic/Hospital

INFORMATICS/DATA SCIENCE

WHO ARE THE INVESTIGATORS ON THESE TEAMS?

People (with or without diseases) Public Health, Community

WHAT (AND WHOM) IS A STAKEHOLDER

• Stakeholder is an independent, engaged, individual or

group who has a stake in the outcome, and whose input could greatly enhance the research endeavor.

• Type of stakeholder may vary depending on the focus of

the problem, the type of research conducted, and the composite and orientation of the investigative team.

Cell/Animal Laboratory Patients Clinic/Hospital

National Center for Accelerated Innovations Council to Advance Human Health

WHO ARE THE STAKEHOLDERS?

People (with or without diseases) Public Health, Community

Safety Net Provider Alliance

Cross-disciplinary teams conducting translational research Research Teams that include relevant Stakeholders – individuals, groups and/or organizations that have a stake in the

• utcome, whose input

could greatly enhance the research endeavor, and that can serve as critical partners in the translational process. Research teams that include both cross- disciplinary investigators AND stakeholders, collectively approaching a problem.

OUR GOAL: PROMOTE A CULTURE OF TEAM SCIENCE WITH STAKEHOLDER ENGAGEMENT

BARRIERS TO TEAM SCIENCE

• Labor Intensive (coordination, communication,

training)

• Administrative complexities (disagreements,

conflict, financial agreements)

• Time cost (up to 200% longer)
• Lack of reward / incentive in academia
• Career jeopardy (less individual recognition,

slower productivity)

COMMUNITY AND COLLABORATION

Promote collaboration through team science, with intentional stakeholder engagement

FOUR AIMS OF THE C&C COMPONENT

• Aim 1: Develop a pipeline of collaborative teams

(interdisciplinary teams with engaged stakeholders) to form and produce novel and relevant translational research;

• Aim 2: Increase awareness and capacity of STAKEHOLDERS to

engage in team science research;

• Aim 3: Increase awareness and capacity of INVESTIGATORS

(faculty, staff and trainees) on importance of team science with stakeholder engagement;

• Aim 4: Cultivate team science with stakeholder engagement

as a valued institutional norm.

AIM 1: DEVELOP PIPELINE OF INTERDISCIPLINARY TEAMS WITH ENGAGED STAKEHOLDERS CONDUCTING TRANSLATIONAL RESEARCH

• Identify and support existing translational collaboratives - those

with interdisciplinary researchers AND stakeholders already at the table.

• Provide resources for collaboratives to come together to

brainstorm, plan and create together (RETREATS)

• Provide pilot funding opportunities for interdisciplinary teams

with engaged stakeholders to conduct translational research projects (TRPs).

AIM 2: INCREASE AWARENESS AND CAPACITY FOR STAKEHOLDERS TO ENGAGE IN TEAM SCIENCE RESEARCH

• Create CWRU CTSA Stakeholder Engagement Guide for researchers

to address stakeholder engagement.

• Develop and disseminate set of training tools intended to increase

STAKEHOLDER understanding and awareness of the translational process and their respective role (suggested by K2A framework)

• Provide stakeholder access to CWRU library, CTSA and other

research-related resources at CWRU

• Develop the Research Grant Prep Resource (RGPR) to make it easier

for stakeholder to become key partners in research applications.

• Develop and promote a broad set of resources to investigators

to support team science and stakeholder engagement.

• Promotion of Team Science course for K and T scholars.
• Develop portable team science training resources using both

CWRU and national resources.

• Develop and disseminate set of training tools intended to

increase INVESTIGATOR understanding and awareness of the translational process and their respective role (suggested by K2A framework). AIM 3: INCREASE AWARENESS AND CAPACITY OF INVESTIGATORS (FACULTY, STAFF AND TRAINEES) ON IMPORTANCE OF TEAM SCIENCE WITH STAKEHOLDER ENGAGEMENT

AIM 4: CULTIVATE TEAM SCIENCE WITH STAKEHOLDER ENGAGEMENT AS AN INSTITUTIONAL NORM

• Develop the annual Faculty Activity Summary Form (FASF) as a

mechanism for tracking team science collaborations and stakeholder engagement among faculty investigators

• Improve awareness of team science across the institutions through

Team Science Success stories.

• Launch a quarterly Team Science (with stakeholder engagement)

seminar series.

• Conduct and annual Team Science and Stakeholder Engagement

survey (to serve as both a norm building activity and tracking method).

EARLY SUCCESSES OF C&C

• National Team Science Consultation (Maritza Salazar , UC Irvine)
• Team Development Retreats

– Four hour retreat with professional group facilitation – 6 teams (76 team members including 25 stakeholders) – Teams completed Team Action Plan (TAP) outlining three translational research projects (TRPs)

• Pilot Funding

–Two $30,000 awards for translational research projects conducted by interdisciplinary research team using team science with stakeholder engagement

Team Development Awards

• Goal: to support, promote and highlight multi-disciplinary

collaboratives that have come together to address a particular health issue or problem facing the local community.

• Teams must have investigators from > 1 discipline and have at least

1 external stakeholder.

• Provide space for teams to brainstorm, receive help with team

dynamics and processing, and to ultimately develop a feasible and actionable plan that identifies a minimum of three translational research projects (TRPs).

• Six teams selected.

Team Development Awardees

• Human Fusions Initiative (Dr. Brian Gran, Sociology)
• Reinventing Health Surveillance to Leverage Developing

Technology for Health Improvement (Dr. Scott Frank, PQHS)

• Team Science for Interprofessional Education (Dr. Catherine Demko, School of

Dentistry)

• Building a Translational Research Agenda to Promote

Environmental Health in NE Ohio (Dr. Darcy Freedman, PQHS)

• Achieving Health Equity through Cross-Sector Collaboration

Focused on Systems Change (Dr. Heidi Gullet, Family Medicine)

• Addressing Tobacco Use Disparities in Cleveland (Dr. Elaine Borawski,

PQHS)

NEXT STEPS

• Understand climate of team science across CTSC institutions
• CTSC-wide survey
• Identify and highlight existing multidisciplinary teams with

engaged stakeholders

• Engagement with new/emerging multidisciplinary teams

– Additional facilitated retreats – Additional pilot funding

• Team development / team functioning self-help tools (website)
• Evaluate current promotion and tenure policies (CWRU) –

– Reward and collaboration and stakeholder engagement

WHAT CAN YOU DO?

• Help us identify successful teams at Metro.
• Spread the word about our team science and stakeholder

engagement resources.

• Help us to identify potential collaboratives – groups that have

already brought together diverse investigators with engaged stakeholders.

• USE OUR TEAM SCIENCE AND STAKEHOLDER ENGAGEMENT

RESOURCES.

• Apply for pilot grant funding!
• Share what you (personally and Metro) offer students, staff and

faculty in the areas of TS and SE.

DISCUSSION

• What are your experiences with Team Science?
• What types of difficulties have you encountered when

working with a multidisciplinary research team?

• Have you had experiences bringing stakeholders into the

research process?

• How to link with investigators within the health systems?