Summary Brief Information on Nanofibers Electro Hydrodynamic - - PowerPoint PPT Presentation
Summary Brief Information on Nanofibers Electro Hydrodynamic Atomization (EHDA) Processes: Electrospinning and Electrospraying Research Statistics Nanofibers in Biomedical Field Market Analysis For Nanofibers In Biomedical Field
Human Hair Nanofibers
High Surface Area (1-1000 m²/g) High Porosity (ca. 80%) Flexibility Small diameters (10 nm-200 nm)
Electrohydrodynamic atomization phenomena is used for building micro- or nanometer architectures, such as fibers and encapsulated particles with a controllable microstructure. Electrohydrodynamic atomization techniques:
1. Electrospraying 2. Electrospinning.
Wu, Y., & Clark, R. L. (2008).
The liquid flowing out of a capillary nozzle, which is maintained at high electric potential, is forced by the electric field to be dispersed into fine droplets.
Steps of micro- and nanoparticle production via electrospraying. Schematics of setup for electrospraying
(Wu Y (2014)) (Jaworek, A., & Sobczyk, A. T. (2008))
Electrospinning is a fiber production method which uses electric force to draw charged threads of polymer solutions or polymer melts up to fiber diameters in the order of some hundred nanometers.
Morota, K and others (2004)
A basic electrospinning system mainly consists of three parts;
The difference between the electrospinning and electrospraying techniques lies in the chain entanglement density of the polymer solution.
Surface SEM images of electrospun thin films from polymer solution with various concentrations at 4.5 kV: (a) 5, (b) 10, (c) 20, (d) 30, (e) 40, (f) 50, (g) 60, and (h) 70 g/L. Morota, K and others (2004) (URL-1 Electrospinning Cost Action MP1206)
Data is generated on SCOPUS database Keywords: electrospinning OR nanofibers OR electrospun OR nanofiber Searched In: TITLE-ABSTRACT-KEYWORDS
33 50 71 153 266 388 709 1067 1493 1835 2400 2820 3181 3975 4300 4913 5733 6019 6325 7002 7573
1000 2000 3000 4000 5000 6000 7000 8000 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018
PAPERS PUBLISHED YEARS Data Generation Date: 07 October 2019
Data was taken from ESPACENET Worldwide by Searching «nanofiber or electrospinning» in «Title or Abstract» for 2001 to now.
17 57 71 121 160 258 324 419 476 617 644 821 1010 1079 1323 1472 1749 2074 500 1000 1500 2000 2500 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018
PATENTS YEARS Data Generation Date: 07 October 2019
Factors to be considered for designing efficient drug delivery systems.
Ramakrishna, S. (2017).
(Zamani et. al., 2013)
Correia, I. J. (2018). Representation of the properties that electrospun membranes must display to be used as wound dressings.
Nanofibrous tubular vascular scaffold produced using Inovenso NS24
The global nanofiber materials market for the biomedical industry was valued at $79.82 million in 2016 and is estimated to reach $227.45 million by 2021, growing at a CAGR of 23.3%.
79.82 97.44 119.71 147.62 182.54 227.45
22.07 22.86 23.31 23.66 24.6
20 25 30 35 50 100 150 200 250 2016 2017 2018 2019 2020 2021
Growth Rate (%) Market Size (USD millions)
Market Size Growth Rate
TYPE 2016 2021 Filters and membranes 35,12 106,26 Medical textiles and wound dressings 20,75 60,66 Tissue engineering 12,77 34,2 Drug delivery 6,39 15,57 Others 4,79 10,76
Filters and membranes 44% Medical textiles and wound dressing 26% ue engineering 16% Drug delivery 8% Others 6%
2016
Filters and membranes 47% Medical textiles and wound dressing 26% Tissue engineering 15% Drug delivery 7% Others 5%
2021
Other applications of nanofibers in the biomedical industry include biosensors, dental fixtures, and stem cell therapy
Conventional needle-based Systems Inovenso’s Hybrid Electrospinning Systems Needleless Electrospinning systems Easy to set-up Easy to set-up Complex set-up procedure All polymers can be used, but fast evaporating solvents can cause needle clogging. Possible to work with all kinds of polymer solutions. No clogging problem. Not possible to work with fast evaporating solvents. Low electrical power. 10 – 30 KV Relatively higher power Up to 50KV Very high electrical power. 80 – 120 KV Uniform jet distribution Uniform and stable jet distribution Non-controllable jet during the
Low production rate High production rate High production rate Full control of the process Precise and full control of the process Hard to control the process parameters Defectless Nanofibers Defectless Nanofibers Beaded and defected structures Uniform fiber morphology Uniform morphology Non-uniform morphology
14G 14G 14G Hybrid Nozzle Hybrid Nozzle Hybrid Nozzle
Inovenso researches, develops, designs and produces high quality electrospinning machines and offer services related to Nanofibers- Based products development and contract manufacturing. Inovenso’s Founders started their researches under structure of Nanofiber Membrane Group of Istanbul Technical University (ITU) in 2005 and commercialized their activities under Inovenso in ITU Technology Development Center in Istanbul, Turkey in 2010. Inovenso US Company is established in Boston/Massachusetts in 2017 both for the US based and Canadian Customers, also for the potential collaborations and projects with academia.
electrospinning technology.
distributors.
method of electrospinning, Hybrid Technology.
national and international projects.
Wu, Y., & Clark, R. L. (2008). Electrohydrodynamic atomization: a versatile process for preparing materials for biomedical applications. Journal of Biomaterials Science, Polymer Edition, 19(5), 573– 601 Jaworek, A., & Sobczyk, A. T. (2008). Electrospraying route to nanotechnology: An
219. Wu Y (2014) Electrohydrodynamic Atomization Processing Biologically Nanostructured Materials Bioceram Dev Appl 4:e105. doi:10.4172/2090- 5025.1000e105 Morota, K., Matsumoto, H., Mizukoshi, T., Konosu, Y., Minagawa, M., Tanioka, A., … Inoue, K. (2004). Poly(ethylene
thin films produced by electrospray deposition: morphology control and additive effects
alcohols
nanostructure. Journal of Colloid and Interface Science, 279(2), 484–492 Langer, R. & Vacanti, J. Tissue engineering. Science (80-. ). 260, 920–926 (1993). Kenry, C.T. Lim / Progress in Polymer Science 70 (2017) 1–17 Vasita, Rajesh; Graduate Student Dept. of BSBE, IIT Kanpur, Synthesis of artificial tissue: A nanofiber- based biomimetic approach. Kenry, & Lim, C. T. (2017). Nanofiber technology: current status and emerging developments. Progress in Polymer Science, 70, 1–17. Miguel, S. P., Figueira, D. R., Simões, D., Ribeiro, M. P., Coutinho, P., Ferreira, P., & Correia, I. J. (2018). Electrospun polymeric nanofibres as wound dressings: A review. Colloids and Surfaces B: Biointerfaces, 169, 60–71. Dhand, C., Dwivedi, N., Sriram, H., Bairagi, S., Rana, D., Lakshminarayanan, R., … Ramakrishna, S. (2017). Nanofiber composites in drug delivery. Nanofiber Composites for Biomedical Applications, 199–223. Zamani M, Prabhakaran MP, Ramakrishna S Advances in drug delivery via electrospun and electrosprayed nanomaterials Int J Nanomed, 8 (2013), pp. 2997-3017
Zhang, et al., Electrospinning and biocompatibility evaluation of biodegradable polyurethanes based
De Valence S, Tille JC, Mugnai D, Mrowczynski W, Gurny R, Moller M, et al. Long term performance of polycaprolactone vascular grafts in a rat abdominal aorta replacement model. Biomaterials 2012;33:38– 47 Ye, K.; Liu, D.; Kuang, H.; Cai, J.; Chen,W.; Sun, B.; Xia, L.; Fang, B.; Morsi, Y.; Mo, X. Three-dimensiona electrospun nanofibrous scaffolds displaying bone morphogenetic protein-2-derived peptides for promotion of osteogenic differentiation of stem cells and bone regeneration. J. Colloid Interface Sci. 2019, 534, 625–636.