Study Update Geraldine Dawson, Ph.D. Duke University ABC-CT PI: - PowerPoint PPT Presentation

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Study Update Geraldine Dawson, Ph.D. Duke University ABC-CT PI: James McPartland, Ph.D. Yale Child Study Center ABC BC-CT CT: Stu tudy De Design Multi-site, naturalistic study 200 children with ASD and 75 typical development

Study Update Geraldine Dawson, Ph.D. Duke University ABC-CT PI: James McPartland, Ph.D. Yale Child Study Center
ABC BC-CT CT: Stu tudy De Design • Multi-site, naturalistic study • 200 children with ASD and 75 typical development • Ages 6-11 years • IQ 60-150 • Three time points (Baseline, 6 weeks, 24 weeks) • Biomarkers of of social-communicative function • EEG • Eye-tracking • Standard clinical assessments • Blood draw 2
ABC BC-CT CT: Bio Biomarker Assays • EEG • Eye-tracking • Resting EEG* • Biological motion* • Visual evoked potentials • Activity monitoring • Biological motion • Interactive social task • ERPs to faces* • Pupillary light reflex* • Static social scenes* * EU-AIMS harmonized paradigm * EU-AIMS paradigm 3 3
ABC BC-CT CT: In Interim Analysis • High success rates across biomarker assays • EEG: 96% valid data • Eye-tracking: 100% valid data • Blood draw • Probands: 76.8% • One or both parents: 85.0% • Promising results: Discriminant validity, Test-retest reliability • ERP: N170 latency to faces • Eye-tracking composite 52 • Activity monitoring wks • Interactive social task • Static social scenes 4
ABC BC-CT CT: In Interim Analysis N170 latency to N1 o up upri right face aces Whole sample TD ASD Test p (N=203) (N=60) (N=143) TD vs ASD Mean 204.8 194.3 209.2 F(1,201)=10.7 <.01 SD 30.2 26.8 30.6 Overall TD ASD Test Retest reliability ICC .68 .66 .66 Faster Latency 5
ABC BC-CT CT: In Interim Analysis Eye-tracking com omposite Whole sample TD ASD Test (N=221) (N=64) (N=157) TD vs ASD p Mean .236 .290 .213 F(1,220)=51.5 <.01 SD .225 .073 .070 Histogram of ET Composite Overall TD ASD Test Retest reliability ICC .83 .83 .79 # TD Participants # ASD Participants 6
PI: James McPartland www.asdbiomarkers.org DAAC Admin Core Sites Gerhard Helleman Julie Holub Raphael Bernier April Levin Helen Seow Kasia Chawarska Michael Murias Michael King Geraldine Dawson Adam Naples Susan Faja DCC Michael Platt Charles Nelson Cynthia Brandt Fred Shic Shafali Jeste Jim Dziura Damla Senturk Scott Johnson Alyssa Gateman Catherine Sugar Leon Rozenblit Sara Webb

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