Study Update Geraldine Dawson, Ph.D. Duke University ABC-CT PI: - - PowerPoint PPT Presentation

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Study Update Geraldine Dawson, Ph.D. Duke University ABC-CT PI: - - PowerPoint PPT Presentation

Mar 19, 2023 124 likes •209 views

Study Update Geraldine Dawson, Ph.D. Duke University ABC-CT PI: James McPartland, Ph.D. Yale Child Study Center ABC BC-CT CT: Stu tudy De Design Multi-site, naturalistic study 200 children with ASD and 75 typical development

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Study Update

Geraldine Dawson, Ph.D. Duke University ABC-CT PI: James McPartland, Ph.D. Yale Child Study Center

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  • Multi-site, naturalistic study
  • 200 children with ASD and 75 typical development
  • Ages 6-11 years
  • IQ 60-150
  • Three time points (Baseline, 6 weeks, 24 weeks)
  • Biomarkers of of social-communicative function
  • EEG
  • Eye-tracking
  • Standard clinical assessments
  • Blood draw

ABC BC-CT CT: Stu tudy De Design

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  • EEG
  • Resting EEG*
  • Visual evoked potentials
  • Biological motion
  • ERPs to faces*
  • Eye-tracking
  • Biological motion*
  • Activity monitoring
  • Interactive social task
  • Pupillary light reflex*
  • Static social scenes*

* EU-AIMS paradigm

ABC BC-CT CT: Bio Biomarker Assays

* EU-AIMS harmonized paradigm

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52 wks

  • High success rates across biomarker assays
  • EEG: 96% valid data
  • Eye-tracking: 100% valid data
  • Blood draw
  • Probands: 76.8%
  • One or both parents: 85.0%
  • Promising results: Discriminant validity, Test-retest reliability
  • ERP: N170 latency to faces
  • Eye-tracking composite
  • Activity monitoring
  • Interactive social task
  • Static social scenes

ABC BC-CT CT: In Interim Analysis

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Whole sample (N=203) TD (N=60) ASD (N=143) Test TD vs ASD p Mean 204.8 194.3 209.2 F(1,201)=10.7 <.01 SD 30.2 26.8 30.6

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Faster Latency

ABC BC-CT CT: In Interim Analysis

N1 N170 latency to

  • up

upri right face aces

Overall TD ASD Test Retest reliability ICC .68 .66 .66

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ABC BC-CT CT: In Interim Analysis

Eye-tracking com

  • mposite

Overall TD ASD Test Retest reliability ICC .83 .83 .79 Histogram of ET Composite

# ASD Participants # TD Participants

Whole sample (N=221) TD (N=64) ASD (N=157) Test TD vs ASD p Mean .236 .290 .213 F(1,220)=51.5 <.01 SD .225 .073 .070

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PI: James McPartland www.asdbiomarkers.org Admin Core Julie Holub Helen Seow Michael King DCC Cynthia Brandt Jim Dziura Alyssa Gateman Leon Rozenblit Sites Raphael Bernier Kasia Chawarska Geraldine Dawson Susan Faja Charles Nelson Shafali Jeste Scott Johnson DAAC Gerhard Helleman April Levin Michael Murias Adam Naples Michael Platt Fred Shic Damla Senturk Catherine Sugar Sara Webb