spICP-MS tier 1 method People behind the experiments Anna - - PowerPoint PPT Presentation

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spICP-MS tier 1 method People behind the experiments Anna - - PowerPoint PPT Presentation

spICP-MS tier 1 method People behind the experiments Anna Katarzyna Undas (RIKILT) NanoDefine Outreach Event Brussels, September 2017 NanoDefine is funded by the European Community's Seventh Framework Programme under Grant


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spICP-MS – tier 1 method

“People behind the experiments”

Anna Katarzyna Undas (RIKILT)

NanoDefine Outreach Event

Brussels, September 2017

NanoDefine is funded by the European Community's Seventh Framework Programme under Grant Agreement-604347

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SLIDE 2

RIKILT (Wageningen University & Research)

Wageningen

is your innovative partner for safe and authentic food. We are specialized in (forensic) measurements, perform top level research and by arrangement 24/7 available in case of emergencies

Expertise areas:

  • Food fraud and Composition
  • Effects of substances on humans and animals
  • Measuring and detecting substances
  • Safe food production
  • Training & Consultancy
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RIKILT (Wageningen University & Research)

Wageningen

RIKILT coordinated EU-projects NanoLyse and NanoDefine and was a research partner in many more EU projects focusing on nanotechnology

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NanoDefine project – people behind experiments

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spICP-MS – EU nanomaterial definition

Nanomaterial EU definition: “A natural, incidental or manufactured material containing particles, in an unbound state or as an aggregate or as an agglomerate and where, for 50 % or more of the particles in the number size distribution,

  • ne or more external dimensions is in the

size range 1 nm - 100 nm.”

  • Determination of size
  • Determination of size distribution
  • Number based concentration
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SLIDE 6

spICP-MS method

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SLIDE 7

spICP-MS – method validation

Validation based on:

  • IUPAC “Harmonized Guidelines for Single-Laboratory Validation of Analytical Methods”
  • Eurachem Guide “Fitness for Purpose of Analytical Methods”
  • Commision Decision 2002/657/EC

5 days, n=3 (LOD,LOQ, n=5)

TiO2 in sunscreen Al2O3 in toothpaste Working range 20 – 500 nm 48 – 500 nm Repeatability (RSDr) [%] 2.4A, 8.0B, 19.9C 5.3A, 5.8B, 2.3C Intermediate precision (RSDRL) [%] 4.0A, 16.5B, 21.3C 15A, 24B, 29C LOD LODs 20 nm LODc 12 mg/kg prod. (10 peaks) LODs 48 nm LODc 61 mg/kg prod. (10 peaks) LOQ LOQs 22 nm LOQc 30 mg/kg prod. (30 peaks) LOQs 70 nm LOQc 180 mg/kg prod. (30 peaks) Measurement uncertainty [%] 5A, 25B, 33C 17A, 25B, 33C

A particle diameter, B particle number conc., C particle mass conc.

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SLIDE 8

Analysis of commercially available toothpaste

Product Median size [nm] a 154 b 126 c 143 d 140 e 123 f 110 g 143 h 106

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SLIDE 9

Interesting posters

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SLIDE 10

www.NanoDefine.eu

This project has received funding from the European Union’s Seventh Programme for research, technological development and demonstration under grant agreement No 604347