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Signal Processing for Medical Applications Frequency Domain Analyses Muthuraman Muthuraman Christian-Albrechts-Universitt zu Kiel Department of Neurology / Faculty of Engineering Digital Signal Processing and System Theory Lecture 4


  1. Signal Processing for Medical Applications – Frequency Domain Analyses Muthuraman Muthuraman Christian-Albrechts-Universität zu Kiel Department of Neurology / Faculty of Engineering Digital Signal Processing and System Theory

  2. Lecture 4 – Different windows used for estimation Coherence • The coherence analysis is an extensively used method to study the correlations in frequency domain, between two simultaneously measured signals. • y ( t ) Let and be two simultaneously recorded data sets of length . x ( t ) N s • s s We estimate the short-time power spectra of , , and cross-spectrum, xy yy xx which is the Fourier transform of the cross-correlation function of the signals x ( t ) y ( t ) and in each segment. • Finally , we average the power spectra and the cross-spectrum across all the segments and calculate the coherence as follows: 2  s ( )   xy (4.1) C ( )   s ( ) s ( ) xx yy Digital Signal Processing and System Theory| Signal Processing for Medical Applications | Introduction Slide I-2

  3. Lecture 4 – Different windows used for estimation Significance of Coherence • The coherence spectrum represents the strength of correlation between two signals, ( t ) y and . x ( t )  • 100 % The confidence limit for coherence at the is given by      1 ( M 1 ) 1 ( 1 ) C (4.2) L  M = 0.99; and is the number of disjoint segements;   1 ( M 1 ) hence the confidence limit is . 1 0 . 01 • D N C If the signal length =10000; =1000; = ?; L • Frequency resolution If (i.e. the number of data points sampled per second) f s is the sampling frequency, then the frequency resolution is . f s D • D Thus, one should optimally choose the value of depending on the purpose of analysis, to compromise between sensitivity and reliability. Digital Signal Processing and System Theory| Signal Processing for Medical Applications | Introduction Slide I-3

  4. Lecture 4 – Different windows used for estimation Significance of Coherence Digital Signal Processing and System Theory| Signal Processing for Medical Applications | Introduction Slide I-4

  5. Lecture 4 – Different windows used for estimation Dynamical Coherence • The dynamical coherence analysis is done by estimating the coherence spectra for a moving 30-second windows with an overlap of 28-seconds, resulting in an apparent time resolution of 2s.       • y [ n ] a y [ n 1 ] a y [ n 2 ] [ n ] A model is created by coupling two AR2 processes . One 1 2    AR2 (V1) had narrow band characteristics and the other (V2) ( a 1 . 9691 , a 0 . 9753 ) 1 2    had broadband spectral characteristics . ( a 0 . 37486 , a 0 . 36788 ) 1 2 • These two processes were simulated for a duration of 150 seconds at a sampling rate of 1,000 Hz. The narrow band AR2 was then band-pass filtered around its spectral peak between 8 and 15 Hz and then combined by point-by-point summation with the broadband AR2 (V2) as follows: V=V2+0.2 V1. • Independent white noises were added to V and V1 whose amounts were tuned so that overall coherence between V and V1 was around 0.1. Digital Signal Processing and System Theory| Signal Processing for Medical Applications | Introduction Slide I-5

  6. Lecture 4 – Different windows used for estimation Dynamical Coherence Digital Signal Processing and System Theory| Signal Processing for Medical Applications | Introduction Slide I-6

  7. Lecture 4 – Different windows used for estimation Welch periodogram and Multitaper Method • Estimation of coherence with these two methods which work on the same principle Multitaper Method with single hanning taper Hanning window in Welch periodogram Method Tapers Hanning Window Digital Signal Processing and System Theory| Signal Processing for Medical Applications | Introduction Slide I-7

  8. Lecture 4 – Different windows used for estimation Increasing Time Resolution  •  If we consider a finite length sample of a discrete time process , . Let us x ( t ) t 1 , 2 , N assume a spectral representation for the process, 1 / 2    x ( t ) X ( f ) exp ( 2 ift ) df (4.3)  1 2 ~ f • The Fourier transform of the data sequence is therefore given by x ( ) 1 / 2 N   ~         (4.4) x ( f ) x ( t ) exp ( 2 ift ) K ( f f , N ) X ( f ) d f  1 1 / 2 • The Welch periodogram method is capable of also analysing the signals using larger time windows in the time domain which inturn gives a good estimation of the signal components. • However, when shorter time windows need to be used, some disadvantages of this method become evident when applied to non-linear signals. • In this case for a stationary process, the spectrum is given by   (4.5)  2 S ( f ) df E X ( f ) Digital Signal Processing and System Theory| Signal Processing for Medical Applications | Introduction Slide I-8

  9. Lecture 4 – Different windows used for estimation Increasing Time Resolution • A simple estimation of the spectrum (apart from the normalization constant) is ~ f 2 obtained by squaring the Fourier transform of the data sequence, i.e; . x ( ) • This suffers from two difficulties: ~ f • Firstly, is not equal to , except when the data length is infinite, in which x ( ) X ( f ) case the kernel in equation (4.5) becomes a delta function. Rather it is related to by a convolution as given in equation (4.4). X ( f ) • This problem is usually referred to as „ bias “ corresponding to a mixing of information from different frequencies of the underlying process due to a finite window length. • Secondly, if the data are stochastic, then the squared Fourier transform of a time series is an inconsitent estimator of the spectrum, because it does not converge to the „ true “ spectrum when the data series tends to infinite length. • Inorder to overcome all these disadvantages, the signals can be analysed with the multitaper and the extended continous wavelet-transform method. Digital Signal Processing and System Theory| Signal Processing for Medical Applications | Introduction Slide I-9

  10. Lecture 4 – Different windows used for estimation Multitaper Method • If is the signal then the spectrum in this method is calculated by multiplying x ( t ) the data with several orthogonal tapers (windows) 2 K 1  ~    S ( ) X ( ) MT k K  (4.6) k 1 ~  where is the Fourier transform X ( ) k      x ( t ) of the data     X ( ) x ( t ) exp( 2 i t ) dt       N ~       X ( ) w ( k ) x exp( 2 i t ) (4.7) k t t  t 1  where are the orthogonal tapers.  w t ( k )( k 1 , 2 , K ) K • A particular choice of these taper functions, with optimal spectral concentration properties, is given by the discrete prolate spheroidal sequences (DPSS). Digital Signal Processing and System Theory| Signal Processing for Medical Applications | Introduction Slide I-10

  11. Lecture 4 – Different windows used for estimation Multitaper Method • th N Let be the DPSS of length and frequency bandwidth parameter W w t ( k , W , N ) k • Consider a sequence of length whose Fourier transform is given by N w t  N      , we find the sequences so that the spectral amplitude w U ( ) w exp( 2 i t ) t t   1  (  is maximally concentrated in the interval , i.e. W , W U ) 2  W (4.8) U ( f ) df  W is maximised. • The maximisation problem leads to the matrix eigenvalue equation      N sin 2 W ( t t )  (4.9)   w w     t t ( t t )  t • Eigen vector – Let be a square matrix, a non-zero vector is called a eigen A C  vector of if and only if there exists a number (real/complex) such that A   AC C . Digital Signal Processing and System Theory| Signal Processing for Medical Applications | Introduction Slide I-11

  12. Lecture 4 – Different windows used for estimation Extended Continous Wavelet Transform Method Digital Signal Processing and System Theory| Signal Processing for Medical Applications | Introduction Slide I-12

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