Service Oriented Data Integration for a Biomedical Research Network - - PowerPoint PPT Presentation

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Service Oriented Data Integration for a Biomedical Research Network - - PowerPoint PPT Presentation

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Oral presentation at MIE 2011 Service Oriented Data Integration for a Biomedical Research Network Matthias Ganzinger a, , Tino Noack a , Sven Diederichs b,c , Thomas Longerich c , Petra Knaup a a Department of Medical Informatics, University of

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Service Oriented Data Integration for a Biomedical Research Network

Matthias Ganzinger Oslo, August 30, 2011

Oral presentation at MIE 2011

Matthias Ganzingera,, Tino Noacka, Sven Diederichsb,c, Thomas Longerichc, Petra Knaupa a Department of Medical Informatics, University of Heidelberg, Heidelberg, Germany b Helmholtz-University-Group “Molecular RNA Biology & Cancer”, German Cancer Research Center (DKFZ), Heidelberg, Germany c Institute of Pathology, University of Heidelberg, Heidelberg, Germany. Corresponding Author: Matthias Ganzinger, Dpt. of Medical Informatics, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany; E-mail: matthias.ganzinger@med.uni-heidelberg.de

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Overview project TRR77

  • Research network Transregio 77: „Liver Cancer.

From molecular pathogenesis to targeted therapies.”

  • 22 projects

– From chronic liver disease to tumor formation – Basic molecular mechanisms / novel targets – Novel approaches to therapy

  • TRR 77 is funded by German Research

Foundation (DFG)

MIE 2011 Matthias Ganzinger

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Project locations

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Overview TRR 77

  • Goal: Availability of data for cross-project

analysis

  • Types of data:

– tissue – molecular – genomic – clinical

MIE 2011 Matthias Ganzinger

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Challenges

  • Local data storage and evaluation, e.g.

Excel files

  • Heterogeneous data structures
  • Data ownership and access control
  • User interface for scientists

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Cross project data integration

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Common user interface Cross project query layer

Access control Access control Access control Access control Access control

Project Project Project Project Project

Projects keep control over data

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Data service and directory

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Vocabulary Metadata

Directory Service Service

Technical description

  • f the service interface

(WSDL) Semantic descripton of the service Publish to directory service Use of standardised vocabulary Terminology Harmonisation Committee

MIE 2011 Matthias Ganzinger

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pelican

platform enhancing liver cancer networked research

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P 1 P n P 2 Cross TRR

Vocabulary Metadata

Directory Service

? ? !

Process Process Chain Data Service Analytical Service

pelican is based on caBIG https://cabig.nci.nih.gov

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Discussion

  • Integrated vs. federated data storage
  • Data services are generated by caCORE
  • caBIG considered as SOA construction kit

with biomedical context

  • Some tools are hard to handle (caDSR)

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Future research

  • Collect metadata
  • Improve user interface
  • Intellectual capital concerns
  • Add more analytical and data services

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