SELF-CLEARING IMPLANTABLE BIOSENSORS FOR NEURODEGENERATION RESEARCH - - PowerPoint PPT Presentation
Towards SELF-CLEARING IMPLANTABLE BIOSENSORS FOR NEURODEGENERATION RESEARCH Hyowon Hugh Lee Assistant Professor Weldon School of Biomedical Engineering Purdue University Acknowledgements first Grad Students: Qi Yang Hyunsu Park
Hyowon “Hugh” Lee
Assistant Professor Weldon School of Biomedical Engineering Purdue University
Grad Students: Qi Yang Hyunsu Park Tran Nguyen James Nolan Angel Enriquez Haesoo Moon Jongcheon Lim Jian Xu – Postdoc Jinjia Xu – Postdoc Collaborators: Riyi Shi, Herman Sintim, Bryan Boudouris
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LICOX Brain Tissue Oxygenation Monitor Integration Neurosciences: 7-14 days G6, Dexcom CGM: 10 days Eversense, Senseonics: 90 days Abbott Freestyle Libre CGM: 14 days
75 years 0 years
Spinal cord neuron Reactive astrocyte Immune system cell Astrocyte Resting microglia Apotosis Cellular debris Exctitotoxicity and
Normal spinal cord Primary injury
itoto
Secondary injury
Demyelination Severe axon
Activated microglia
5 50 µm 100 µm
Nguyen et al., Biosens. Bioelectron. 2019
a.
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Time (s)
1200 1300 1400 1500 1600 1700 1800
Current Density (nA/mm2)
200 400 600 800 1000 1200 1400 1600
50 µM 50 µM 50 µM 200 µM 200 µM PtNPs-MWCNT-PEDOT:PSS-Nafjon-GluOx MWCNT-PEDOT:PSS-Nafjon-GluOx PEDOT:PSS-Nafjon-GluOx
c.
Device in the spinal cord
Nguyen et al., Biosens. Bioelectron. 2019
Prevent & Disrupt Biofouling! Strategy: Use Active and Passive Approaches
𝜚 = 𝑊
$𝑁𝐼𝑡𝑗𝑜 * + − 𝜚 /k/012
𝑙456$ = 𝐹𝐽 𝑀 , 𝐽 = 𝑥𝑢= 12
𝜚
H = 0 H = 16kA/m
Dynamic responses of microactuators
*
*
Moving forward Moving backwards
Large amplitude actuation for self-cleaning
Removing blood clot obstruction
Yang et al., S&A:B, 2018
Unpublished