Roundtable Discussion: Role of Mode of Action in Dose- Response - PowerPoint PPT Presentation

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Roundtable Discussion: Role of Mode of Action in Dose- Response Assessment for Carcinogens Moderator: Elaine Faustman, PhD All speakers Questions welcome. Conflict of Interest Statement Moderator No Conflicts for symposium Overall

Roundtable Discussion: Role of Mode of Action in Dose- Response Assessment for Carcinogens Moderator: Elaine Faustman, PhD All speakers Questions welcome.
Conflict of Interest Statement Moderator – No Conflicts for symposium Overall research program receives funding from USEPA, NIEHS and WESTAT.
Questions  Clarify MOA and AOP concepts – Can they inform one another? How?  Discuss criteria used for evaluating MOAs across multiple chemicals? Multiple endpoints? Can this be incorporated for dose response?  Can chemicals have more than one MOA?  Please discuss if Modulating Factors (ModFs) are designed to include PBPK Biomarker information. If so, how?  How is genetic diversity included for MOAs?
Colloquia  Recordings  Slides  Captioning Text are available at www.toxicology.org
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