Resear arch Done Differ erently ently: : The In Ins and Ou d - - PowerPoint PPT Presentation
Resear arch Done Differ erently ently: : The In Ins and Ou d Outs of Pat Patien ient- Ce Centered ed Outco comes mes Resear arch Ayodola Anise, MHS Program Officer, Healthcare Delivery and Disparities Research Program Clinical
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authorized by Congress in 2010 and governed by a 21-member Board of Governors representing the entire healthcare community
effectiveness research (CER) that engages patients and other stakeholders throughout the research process
circumstances and concerns
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PCORI helps people make informed healthcare decisions, and improves healthcare delivery and
re resear search h guide ded d by pa pati tients, ents, care regive vers, s, and d th the e br broade ader r healthcare althcare comm mmuni unity ty. . Our r Str Strat ategic egic Goals: als: Increase quantity, quality, and timeliness of useful, trustworthy research information available to support health decisions Speed the implementation and use of patient-centered outcomes research evidence Influence research funded by others to be more patient-centered
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mpare ares s tw two or r more re commonly used
ptions
conditions
r B is is be bett tter er and for r which h pa pati tients ents
s evide dence ce gaps ps that are important to patients and other key stakeholders
real al-worl
d po popu pulations ations and re real al-world world se setti tting ngs
context of patient preferences and interests
what is important to patients and caregivers
the entire study
Change ge in St Study dy Inter ervent entions
Refocus
Outcom comes es Boost Recruit uitmen ment Share e Their eir St Story/Present y/Present St Study dy Findi dings ngs
Assessment ent of Prevent ention ion, , Diagno gnosis is, , and Treat atmen ent Option
Improving Healthcare Systems Communication & Dissemination Research Addressing Disparities Accelerating PCOR and Methodological Research
Assessment of Prevention, Diagnosis, and Treatment Options Research that:
safety of alternative prevention, diagnosis, and treatment options
different people with a particular health problem
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Assessment of Prevention, Diagnosis, and Treatment Options Impr proving ng Healt lthcare hcare Syste tems ms Research that:
approaches to improving access
use of health information technology, care coordination for complex conditions, and effective workforce deployment
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Assessment of Prevention, Diagnosis, and Treatment Options Improving Healthcare Systems Comm
unication cation and d Diss ssem eminat ination ion Resea esearch
Research on:
CER
use the information
between patients and their providers
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Assessment of Prevention, Diagnosis, and Treatment Options Improving Healthcare Systems Communication and Dissemination Research Add ddre ressing ssing Di Disp spariti rities es
Research on:
effectiveness
patient populations at risk for disparities
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Assessment of Prevention, Diagnosis, and Treatment Options Improving Healthcare Systems Communication and Dissemination Research Addressing Disparities Acceler elerating ating Pa Patient tient-Center Centered ed Outc tcom
es Resear esearch h and d Method thodologic
al Resear esearch
Research on:
this research
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Numbe ber r of funded ded awa wards: ds: More than 600 Amou
nt awa warded ded: : More than $2 billion Numbe ber r of stat ates es where re we we are re fundi ding ng pr proje jects ts: : 41 (plus the District of Columbia)
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AS OF APRIL 2018
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PCORI has funded 224 studies determining what works best in care for the 16 highest cost conditions in the United States.
$32,027 $15,920
National Per Capita Expenditure Conditi dition Numbe ber r of PCORI RI Studies dies PCORI RI Inve vestme tment nt
Stroke 10 $41 M Heart Failure 14 $68 M Hepatitis (Chronic Viral B and C) 8 $59 M Chronic Obstructive Pulmonary Disease 17 $89 M Schizophrenia/Other Psychotic Disorders 11 $22 M Chronic Kidney Disease 16 $67 M Asthma 16 $51 M Atrial Fibrillation 3 $5 M Alzheimer's Disease/Dementia 12 $64 M Depression 35 $122 M Cancer 77 $285 M Ischemic Heart Disease 19 $94 M Osteoporosis 1 $14 M HIV/AIDS 4 $8 M Arthritis 13 $43 M Diabetes 29 $68 M
High-cost clinical conditions identified by the Centers for Medicare and Medicaid Services for 2015. The PCORI CER portfolio includes 392 active/completed studies funded as of September 12, 2017. Analysis excludes methods studies, Pilots, PPRNs, CDRNs, and Engagement Awards.
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Guiding Principle
To support comparative effectiveness research that will identify best options for reducing and eliminating disparities
Addressing Disparities Priority Area Mission Statement
To reduce disparities in healthcare outcomes and advance equity in health and healthcare
PCORI’s Vision, Mission, Strategic Plan
relevant to reducing and eliminating disparities in health and healthcare outcomes
the highest potential to reduce and eliminate health and healthcare disparities
promising/best practices to reduce and eliminate health and healthcare disparities
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Numbe ber r of funded ded awa wards: ds: 81 Amou
nt awa warded ded: : $250 million Numbe ber r of stat ates es where re we are re fundi ding ng pr projec ects ts: : 25 (plus the District of Columbia)
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70 70 59 59 27 27 19 19 6 4 Racial/Ethnic Minorities Low-Income Low Health Literacy Rural Persons with Disabilities LGBTQ
# of Projects in Portfolio
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Condition ndition # of
jects
Mental/Behavioral Health 16 Respiratory Diseases 11 Nutritional and Metabolic Disorders 10 Cardiovascular Health 8 Neurological Disorders 6 Multiple/co-morbid chronic conditions 5 Cancer 4 Reproductive and Perinatal Health 2 Liver Disease 2 Functional Limitation and Disabilities 1 Other 16
Total 81 81
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STUDY PROFILE
Project looks at whether a community engagement intervention or technical assistance model will improve clients’ mental health and physical functioning and reduce risk factors for homelessness. It will also identify patient preferences and priorities and assess community capacity to respond to these priorities.
Kenneth Brooks Wells, MD, MPH University of California, Los Angeles Addressing Disparities, awarded December 2012
Engagemen gagement
needs and strengths of community.
Methods thods
Resu esults ts
health quality of life. People in programs assigned to the coalition approach showed more improvement in physical health quality of life and averaged fewer nights in the hospital for mental health problems.
Our research funding is awarded through PCORI Funding Announcements. Open opportunities are posted at pc pcori ri.o .org/ap g/appl ply.
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http://www.pcori.org/funding-opportunities
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importance to patients and other stakeholders.
Priorities for Research
years in duration
ember r 6, 2018; Application: Ja Janu nuar ary y 16,20 2019
Januar uary y 31, 2019; Application: Apr pril 24, 2019
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generation and research prioritization process
– Clinical Management of Hepatitis C Infection – Treatment of Multiple Sclerosis – Management of Care Transitions for Emerging Adults with Sickle Cell Disease
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ammatic c Inqu quire res: s: Email: sciencequestions@pcori.org Phone: 202-627-1884 Research Inquiry Form: http://www.pcori.org/PFA/inquiry
dminis inistr trati ative ve, , Fin inancial, ncial, or r Techn hnic ical al Inqu quiri iries: es: Email: pfa@pcori.org Phone: 202-627-1885
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Pre reliminar liminary y re revi view ew of full ll app ppli licati ations
. Reviewers conduct a preliminary review of applications, providing written critiques and scores for the applications based on our review criteria and scoring system. Eva valuat luate Lett tter ers s of Inte tent.
committee of staff members determines which will be invited to submit full
clinicians, scientists, and other members of the healthcare community who have the appropriate expertise to serve on merit review panels.
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Selecti ection
mittee Review view. . Program staff recommend projects to a Selection Committee that includes members of PCORI’s Board of Governors. The committee identifies a slate of applications for possible funding based on merit review scores, programmatic balance and fit, and PCORI’s strategic priorities. This slate is proposed to PCORI’s Board for consideration and approval.
In In-per person son pa panel el re review iew. . Following the preliminary review, a subset of applications move forward and are discussed and scored by the full panel of merit reviewers at an in-person meeting. The perspectives of a wide range of reviewers help us choose projects that are important, practical, and relevant to the audiences who will use the results of our work.
Pa Patien ent/Oth Other er St Stake keholder r Reviewe wers Scientis tist t Reviewe wers Criterion 1: Potential for the study to fill critical gaps and generate actionable evidence
Criterion 2: Potential for the study findings to be adopted into clinical practice and improve delivery of care
Criterion 3: Scientific merit (research design, analysis, and outcomes)
Criterion 4: Investigator(s) and environment Criterion 5: Patient-centeredness
Criterion 6: Patient and stakeholder engagement
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ad PFAs carefully efully
peak/email ail with h PCORI RI progr gram am staff f early and as needed
ORI-funded funded stud udies ies on your topic/condition/intervention to identify differences and call out the evidence gaps filled by your proposal
ematic reviews iews and d guide idelines lines that identify current gaps in the evidence and document that the topic is a high-priority for patient and other stakeholder partners, PCORI, Institute of Medicine, or the Agency for Healthcare Quality and Research
potenti ential al for your study to impr prove ve th the qu quality ty of th the e evide idence ce available
tudy dy is is of
interes erest t to patients and other stakeholders
pati tient ent- re repor ported ted and d clinical al outc tcomes
inter ervent vention ion comp compon
ents ts will address the identified research gap
erve vention(s) tion(s) and compar parat ator(s
) and provide evidence of proven efficacy cacy, , effecti ectivene veness, ss, or r wide de-spread spread use se (e.g., cite published literature, conduct pilot study provide data, document use in clinical setting)
constantly
uptake and use of research findings
gagement ent of patient and stakeholder partners in developing veloping the resear arch h ques estion ion and d prop
gage patients and other stakeholders ov
e cyc ycle le of f yo your projec ject, from planning and conducting the study to disseminating results
es, respo ponsibi nsibility lity, , and d compensation mpensation of patient and other stakeholder partners
http://www.pcori.org/sites/default/files/Engagement-Rubric.pdf
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Amoun
awa warded ed:
Numb mber er of awa wards: s:
*AS OF APRIL 23, 2018
These awards support projects that promote meaningful involvement by patients, caregivers, clinicians, and other healthcare stakeholders in comparative clinical effectiveness research (CER).
Our Eugene Washington PCORI Engagement Awards and Pipeline to Proposal Awards are not research awards but opportunities to build patient-centered outcomes research capacity.
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St States es with h funded nded projects
(plus us DC and d Puerto
Engagement agement Awa ward: d: Diss ssem emination nation Initi tiati ative ve
Objective: Actively disseminate PCORI-funded research findings Next Letter of Intent due date: October 1, 2018
Engagement agement Awa ward: d: Conference rence Supp pport
Objective: Convene stakeholders and communicate PCORI-funded research finding to a targeted end-user audience Next Application due date: October 1, 2018
Engagement agement Awa ward: d: Capac pacity ty Building ding
Objective: Develop infrastructure and partnerships for dissemination and implementation of PCORI- funded research findings Next Letter of Intent due date: October 1, 2018
Up to $300,0 ,000 00 2 ye year ars Up to $50,000 000 1 ye year ar Up to $250,0 ,000 00 2 ye year ars
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washington-pcori-engagement
ammatic c and d Adm dminis inistr trativ ative Inqu quires: res: Email: ea@pcori.org Phone: 202-370-9312
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