Progress in using prompt gammas for ion range monitoring during - PowerPoint PPT Presentation

Progress in using prompt gammas for ion range monitoring during hadrontherapy J. Krimmer 1 , M. Chevallier 1 , J. Constanzo 1 , M. Dahoumane 1 , D. Dauvergne 1 , M. De Rydt 1 , 2 , G. Dedes 1 , N. Freud 3 , J.M. Létang 3 , M. Pinto 1 , C. Ray 1 , V. Reithinger 1 , M.H. Richard 1 , 3 , F . Roellinghof 1 , 3 , 4 , E. Testa 1 , A.H. Walenta 1 1 IPNL, 2 K.U. Leuven, 3 CREATIS, 4 IBA ICTR-PHE 2012 Geneva, Switzerland J. Krimmer (IPNL) Progress in using prompt gammas for ion range monitoring during hadrontherapy ICTR-PHE 2012

Dose Monitoring during Hadrontherapy measurement of β + activity 12 95MeV/u C, PMMA target, GEANT4.9.4 (200 MeV/u 12 C on a PMMA phantom) counts/ion/mm 0.03 γ n p 0.025 α nuclear reactions 0.02 0.015 0.01 0.005 0 0.5 1 1.5 2 2.5 3 Target depth [cm] goal ◮ 3D reconstruction of applied dose (online) techniques ◮ β + activity ⇒ PET ◮ emitted radiation (p, γ ) for ion range monitoring ◮ proton IVI ⇒ talk E. Testa Wed. 15:45 (Nr. 241) ◮ prompt γ ⇒ this talk J. Krimmer (IPNL) Progress in using prompt gammas for ion range monitoring during hadrontherapy ICTR-PHE 2012

Prompt Gamma Measurements ◮ collimated camera ◮ single and multislit ◮ slit camera ◮ see poster by J. Smeets (Nr. 89) ◮ Compton camera ◮ "electronic collimation" J. Krimmer (IPNL) Progress in using prompt gammas for ion range monitoring during hadrontherapy ICTR-PHE 2012

Common Device: Hodoscope hardware ◮ array of scintillating fibres (1 mm x 1 mm) ◮ 2 prototypes: 2x32 and 2x128 fibres ◮ multianode PM or MCP-PMT ◮ time resolution ≤ 1 ns ◮ goal: count rates up to 10 8 1/s electronics ◮ development of ASIC S. Deng DOI 10.1109/ICECS.2010.5724447 ◮ first version tested at CAL Nice ◮ new version with DLL ⇒ timing see poster M. De Rydt (Nr.136) J. Krimmer (IPNL) Progress in using prompt gammas for ion range monitoring during hadrontherapy ICTR-PHE 2012

Collimated Camera 95MeV 12 C, PMMA target 1.4e-06 data QMD improved 1.2e-06 QMD default 1e-06 counts / ion 8e-07 6e-07 4e-07 2e-07 0 -10 0 10 20 30 40 50 depth in target [mm] ◮ measurements at carbon beams (homogeneous targets): ◮ E. Testa et al. Appl. Phys. Lett. 93 (2008) 093506 ◮ E. Testa et al. NIM B 297 (2009) 993 ◮ M. Testa et al. Radiat. Environ. Biophys. 49 (2010) 337 ◮ improvements in simulations (GEANT4): ◮ G. Dedes poster (Nr.148) J. Krimmer (IPNL) Progress in using prompt gammas for ion range monitoring during hadrontherapy ICTR-PHE 2012

Target Dependence (GANIL) PMMA (1.2 g/cm 3 ) 12 C J. Krimmer (IPNL) Progress in using prompt gammas for ion range monitoring during hadrontherapy ICTR-PHE 2012

Target Dependence (GANIL) PMMA (1.2 g/cm 3 ) PMMA+teflon(2.3 g/cm 3 ) 12 12 C C J. Krimmer (IPNL) Progress in using prompt gammas for ion range monitoring during hadrontherapy ICTR-PHE 2012

Target Dependence (GANIL) PMMA (1.2 g/cm 3 ) PMMA+teflon(2.3 g/cm 3 ) PMMA+lung(0.2 g/cm 3 ) 12 12 12 C C C J. Krimmer (IPNL) Progress in using prompt gammas for ion range monitoring during hadrontherapy ICTR-PHE 2012

First Measurement at the Proton Beam setup results of a scan proton beam tungsten collimator PMMA target LaBr 3 LYSO ◮ proton beam 160 MeV at WPE (Essen) ◮ 2 LYSO detectors ◮ TOF selection: 3 x 40 x 50 mm 3 background reduction ◮ 1 LaBr 3 detector ◮ see talk of F . Roellinghoff ø25.4 mm x 50.1 mm Wed. 15:00, (Nr. 235) ◮ W collimator (100 mm) J. Krimmer (IPNL) Progress in using prompt gammas for ion range monitoring during hadrontherapy ICTR-PHE 2012

Multi-Slit Collimators parallel collimator × -6 10 Count per incident ion ◮ GANIL, 13 C 73 MeV/u on PMMA 3 2.5 2 With TOF selection 1.5 Without TOF selection 1 0.5 0 -10 -5 0 5 10 15 20 25 Longitudinal position (mm) convergent collimator J. Krimmer (IPNL) Progress in using prompt gammas for ion range monitoring during hadrontherapy ICTR-PHE 2012

Compton Camera ◮ intersection: line/cone J. Krimmer (IPNL) Progress in using prompt gammas for ion range monitoring during hadrontherapy ICTR-PHE 2012

Compton Camera: Simulations ◮ scatterer: 10 silicon strip detectors (SSD) 80 x 80 x 2 mm 3 ◮ absorber: LYSO detector 300 x 300 x 25 mm 3 ◮ photons: point source ◮ simulation: hit in SSD + hit in absorber ◮ resolution: 8 mm FWHM ◮ efficiency: 3 · 10 − 4 F . Roellinghoff et al. NIM A 648 (2011) S20-S23 M.H. Richard et al. proceedings IEEE NSS-MIC (2011), Valencia J. Krimmer (IPNL) Progress in using prompt gammas for ion range monitoring during hadrontherapy ICTR-PHE 2012

Compton Camera: Hardware cts/s 152Eu E = 40keV and E = 121.8 keV γ γ -2 10 20 40 60 80 100 120 140 160 E [keV] ◮ Double-sided Silicon Strip Detectors ◮ test detectors (12 x 12 x 2mm 3 ) ◮ 8 strips on each side ◮ energy resolution ∆ E=10 keV goal: ∆ E < 2 keV ⇒ cooling needed ◮ delivery of final DSSD detectors (90 x 90 x 2mm 3 ), 2x64 strips, expected 2012 J. Krimmer (IPNL) Progress in using prompt gammas for ion range monitoring during hadrontherapy ICTR-PHE 2012

Test Measurements: HIT (Heidelberg) carbon LaBr3 cts/s 10 12 scint. beam beam C 310 MeV/u I.C. background target difference beam cut on scint. beam 1 140 173 scint. CC silicon det. -1 10 LaBr det. 3 -2 10 1000 2000 3000 4000 5000 6000 7000 ◮ single rates E [keV] ◮ silicon detector: 2 . 5 · 10 − 4 cts/ion (scaler, thres. 350 keV) ◮ absorber: 4 . 5 · 10 − 3 cts/ion (scaler, thresh 180 keV) ◮ coincidence rates ◮ all events: 2 . 6 · 10 − 5 cts/ion (scaler) ◮ uncharged: 2 . 9 · 10 − 6 cts/ion (software cuts) ◮ extrapolation to prototype dimensions ◮ silicon det.: 1 . 4 · 10 − 2 cts/ion single ◮ absorber: 6 . 6 · 10 − 2 cts/ion single J. Krimmer (IPNL) Progress in using prompt gammas for ion range monitoring during hadrontherapy ICTR-PHE 2012

Test Measurements: HIT (Heidelberg) protons LaBr3 cts/s beam p 160 MeV scint. beam I.C. background target difference beam 1 140 173 scint. CC silicon det. -1 10 LaBr det. 3 -2 10 1000 2000 3000 4000 5000 6000 7000 ◮ single rates E [keV] ◮ silicon detector: 8 . 9 · 10 − 6 cts/ion (scaler, thres. 350 keV) ◮ absorber: 4 . 3 · 10 − 4 cts/ion (scaler, thresh 180 keV) ◮ coincidence rates ◮ all events: 1 . 7 · 10 − 7 cts/ion (scaler) ◮ uncharged: 9 . 2 · 10 − 8 cts/ion (software cuts) ◮ extrapolation to prototype dimensions ◮ silicon det.: 5 · 10 − 4 cts/ion single ◮ absorber: 6 . 3 · 10 − 3 cts/ion single ◮ for protontherapy conditions (10 10 p/s) absorber needs to be segmented J. Krimmer (IPNL) Progress in using prompt gammas for ion range monitoring during hadrontherapy ICTR-PHE 2012

Summary and Outlook ◮ Collimated Camera ◮ prompt γ profiles for p and carbon beams ◮ TOF selection necessary ◮ improvements in simulations ◮ convergent multi-slit collimator ◮ Compton Camera ◮ simulation and test measurements ◮ count rates ◮ cooling for SSD ◮ absorber J. Krimmer (IPNL) Progress in using prompt gammas for ion range monitoring during hadrontherapy ICTR-PHE 2012