Program Initiatives 3 CBCRP Council Meeting June 7, 2019 CBCRP - - PowerPoint PPT Presentation

Updates on

Program Initiatives 3

CBCRP Council Meeting June 7, 2019

CBCRP Program Initiatives

2000 2025 2005 2010 2015 2020

• Environmental contributors
• Health disparities
• Population-level prevention interventions
• Environmental

effects

• Health disparities
• Environmental causes
• Health disparities
• Population-level interventions
• Targeted interventions

California Breast Cancer Prevention Initiatives (CBCPI) Special Research Initiatives (SRI) Program Initiatives 3 (PI3)

• 9 sub-initiatives
• 26 grants
• ~ $21 million
• 15 sub-initiatives
• 18 grants to date
• ~ $17 million to date

PI1 PI2 PI3

Program Initiative Process

2000 2025 2005 2010 2015 2020

Collect Ideas Synthesize & Prioritize Compete & Fund Collect Ideas Synthesize & Prioritize Compete & Fund Collect Ideas Synthesize & Prioritize Compete & Fund

PI3 Focus Areas

• Identify and eliminate environmental

contributors to breast cancer.

• Identify and eliminate fundamental causes of

health disparities with a focus on breast cancer in California.

• Develop and test population-level prevention

interventions that incorporate approaches that address the needs of the underserved and/or populations experiencing disparities in the burden of breast cancer.

Recent Activities

• March 22/25: Calls with PI3 Steering Committee/Strategy

Advisors to refine Environment and Disparities topic lists

• April: Delphi survey to prioritize Environment and

Disparities topics

• May 15: Global Challenge Event Showcase and Competition
• May 15-16: PI3 Steering Committee/Strategy Advisor

meeting Upcoming activities:

• June: Steering Committee meeting to select first round of

topics

• Rest of 2019: Concept paper development
• March/April 2020: Next PI3 Steering Committee/Strategy

Advisor meeting

Delphi Survey (April 2019)

• Iterative multi-round process that aids decision-making

because respondents see first-round results from group before participating in second round.

• Round 1:

– Rate each topic on:

• How well does the research topic increase knowledge and

potentially create solutions?

• How will the research dramatically change how or what breast

cancer research is conducted in the next decade?

• How does the research address special interest in California?
• Round 2 (after seeing results from Round 1):

– Rank top 10 ideas – Weighted Ranking: allocate 100 points across ideas – Which 5 topics would you eliminate?

Delphi Survey Results: Environmental Contributors

Delphi Survey Results: Health Disparities

SC+SA Meeting Outcomes: May 15-16, 2019

• Initial road map of research topics for PI3 (3 years).

Steering Committee and Strategy Advisors will continue to refine

• List of research topics for first round of concept papers

(drafts by for Feb 2020)

– Initial volunteers to serve on concept paper workgroups – Steering Committee to decide which topics to pursue and refine concept paper workgroups

• List of research topics needing additional research or

refinement by February 2020 to determine if they should advance

• Feedback on the fund allocation strategy

– Steering Committee to further refine

Next Steps

• May/June: Steering Committee

members/Strategy Advisors refining batch 1 topics

• June: Steering Committee meets to select

batch 1 topics

• July – February 2020: Batch 1 concept paper

development

• March/April 2020: SC+SA meeting to discuss

concept papers

Topics for Concept Paper Batch 1

Environmental Contributors Health Disparities Population-Level Prevention It is anticipated that two environmental topics will be determined for batch #1 after further refinement. W+T – Biomonitoring with Mixtures (5 votes + 1 vote for add exposome) AA+BB – Implementation Research and Policy (5 votes) O – Three-Generation (4 votes) C+Q – Chemical Testing. Hallmarks of Cancer / Chemical Causing Cancer (4 votes) J – Shift Work and Other Social Environmental Factors (6 votes) A – Life Stressors (5 votes) A - Inflammation, Breast Density, Thermography (9 votes) P+G+H - Community-Level Intervention/ CLASP Proposal (8 votes) Letters refer to Health Disparities

• riginal list

Likely Topics for Concept Paper Batches 2 and 3

Environmental Contributors Health Disparities Population-Level Prevention G – Occupational Cohort (4 votes) D+T – Chemical Testing with Mixtures (1 votes) F – Consumer Products (3 votes) B+C – Differences in Immigrant Groups (2 votes) B – Inflammatory Pathway in an Intervention (3 votes) G – Add Generational Trends to CA Breast Cancer Primary Prevention Plan(0 votes)

Topics that Require Refinement or Research before Advancing

Environmental Contributors Health Disparities Population-Level Prevention Need to be refined A – Searchable Inventory CC – Behavioral/Social Science Intervention V – Ductal Lavage Need more research P+Q: Microbiome and Inflammation Need to be refined H – Recruitment for Policy, Research Funding, Advocacy Need more research D – Bovine (BLV)