Program Initiatives 3 (2016 2021) In March 2015, Council approved - - PDF document

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PROGRAM INITIATIVES 3 UPDATE

Program Initiatives 3 (2016‐2021)

• In March 2015, Council approved PI3 (50% Set‐

Aside)

• Covering Three Areas

– Environmental Contributors to Breast Cancer – Health Inequities/Disparities and Breast Cancer – Population‐Level Interventions Intended to Prevent Breast Cancer

• Currently in the Planning Stage

– Implementation Plan – Timeline with Key Milestones

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Key PI3 Planning Tasks

• 1. Award Competitive RFQ for Convener
• 2. Design and Launch PI3 Challenge
• 3. Explore Funding Partners/Sponsors
• 4. Recruit Steering Committee
• 5. Develop Strategic Development Plan
• 6. Create Community Stakeholder Engagement Plan
• 7. Integrate Evaluation Efforts into the PI3 Process
• 8. Identify Strategy Advisors
• 9. Summarize SRI (and when available, CBCPI) Outcomes
• 10. Conduct Initial Science Reviews

SRI Evaluation

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In 2004, CBCRP launched Special Research Initiatives (SRI), which devoted 30% of CBCRP research funds to support coordinated, directed, and collaborative research in two areas: 1. The effects of the environment on the development of breast cancer 2. Disparities in breast cancer Vision: To fund research that not only increases knowledge about these areas, but also points to solutions that will reduce the suffering from breast cancer and move us closer to eliminating the disease. Goals:

• Support coordinated statewide effort to explore innovative ideas + theories.
• Leverage California’s unique and diverse geographic and population resources.
• Undertake critical studies that significantly move these fields forward.

In Context Special Research Initiatives (SRI) 2004 ‐ 2009

SRI Planning Advisory Groups

Phase 1

• Leadership
• Recruit and form SRI Steering Committee (SC) to provide

guidance throughout the strategy development process.

Phase 2

• State of the Science Review
• CBCRP staff, SC, and Science Advisors generate a document

with comprehensive information on current research and funding surrounding questions investigated under SRI.

Phase 3

• Involve Stakeholders
• Inform stakeholders and engage them in developing

strategy for SRI.

• Recruit and register interested investigators.

Phase 4

• Identify Strategies/Initiatives
• Brainstorm, prioritize, and develop strategies that

coordinate and leverage California resources to conduct

• research. that will have the greatest impact.

Phase 5

• Adopt Strategies/Initiatives
• Advisory Council reviews recommendations from Strategy

Report and identify strategies that CBCRP will begin implementing.

SRI Strategy Development Plan

CBCRP Advisory Council Steering Committee Science Advisors Stakeholders Strategy Team

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Topic Area: Disparities (13 projects)

Initiative: Understanding Racial and Ethnic Differences in Stage‐ Specific Breast Cancer Survival Initiative: Demographic Questions for California Breast Cancer Research Initiative: Piloting an Integrated Approach to Understanding Behavioral, Social, and Physical Environment Factors and Breast Cancer Among Immigrants Race & Ethnicity in Stage‐specific Breast Cancer Survival* California Breast Cancer Survivorship Consortium** Demographic Questions for CA BC Research Immigrant Experience & Breast Cancer Risk in Asians Initiative: Toward the Development of a California Chemicals Policy that Considers Breast Cancer Initiative: Making Chemicals Testing Relevant to Breast Cancer Breast Cancer & Chemicals Policy Biologically Relevant Screening of Endocrine Disruptors Xenoestrogen‐Specific Perturbations in the Human Breast Cell Bioassays for Detection of Aromatase Gene Activators Biomarkers for Environmental Exposures in Breast Cancer Building on National Initiatives for New Chemicals Screening

Topic Area: Environment (6 projects)

Initiative: Statistical Methods to Study Interacting Factors that Impact Breast Cancer Initiative: Toward an Ecological Model of Breast Cancer causation and Prevention Initiative: Environmental Causes of Breast Cancer Across Generations Model‐building with Complex Environmental Exposures New Methods for Genomic Studies in African American Women Cancer Mapping: Making Spatial Models Work for Communities Initiative: Environmental Exposures & Breast Cancer in a Large, Diverse Cohort Persistent Organic Pollutants & Breast Cancer Risk New Paradigm of Breast Cancer Causation and Prevention Environmental Causes

• f Breast Cancer

Across Generations Exploring Disparities, Environmental Risk Factors in Teachers

Topic Area: Disparities & Environment (7 projects)

Special Research Initiatives (SRI)

A collaborative strategic planning effort between CBCRP and more than 50 scientific and advocacy experts in breast cancer, the environment, and disparities which led to an extensive literature review titled “Identifying Gaps in Breast Cancer Research,” that played a role in identifying 9 initiatives for breast cancer research in disparities, the environment, or both disparities & the environment.

*multi‐site collaboration: 6 grants awarded to 4 institutions & organizations **multi‐site collaboration: 5 grants awarded to 4 institutions & organizations

Total Topic Areas: 3 Total Initiatives: 9 Total Grants: 26 Total Funding Amount: $20,593,655

Process/Short Term Outcomes

What investment did the CBCRP make in SRI? How were the SRI initiatives structured? How were the SRI initiatives identified? What types of projects were funded in the SRI? Did SRI build on existing data but avoid duplicating funding strategies by other research funders? Did SRI choose topics based on the most up‐to‐date knowledge and opinion of experts?

Medium Term Outcomes

Were the goals of each initiative met? Did the grants within these initiatives meet their goals? Do the research findings from the SRI grants lead to increased knowledge to reduce the burden of breast cancer? Do the research findings from the SRI grants lead to increased opportunities to move these fields forward in research and/or advocacy? How did the structure of SRI impact the research initiated within each initiative? How did the SRI funded grants leverage California’s unique and diverse, geography, demographics, and research resources?

Long Term Outcomes

Did SRI reach its overarching goal? Did the research produced as a result of SRI stimulate the field of breast cancer research? Was the research produced innovative and/or theory generating? How did the research portfolio change for the researchers who received a SRI grant? How did the SRI influence: CBCRP research portfolio? CBCRP funding priorities? Who benefitted from the research produced by SRI funded grants? Did SRI serve as a pipeline for new investigators interested in these areas?

Special Research Initiatives (SRI) Evaluation Framework

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Evaluation Methods

• Mixed Method Approach

– Document Analyses (Grant documents, SRI planning documents, preliminary evaluation, Council meeting notes) – Database Extraction (internal systems, ICRP, NIH RePORTER, UberResearch) – Survey/Interviews with SRI investigators – Focus Group with SRI advocates – Independent Expert Panel

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SRI Descriptive Analyses

11 1 1 1 5 2 1 1 3 2 4 6 8 10 12 14

Disparities Environment Both Disparities & Environment n = 3 n = 2 n = 4

SRI INITIATIVES BY TOPIC

Initiatives: 3 Grants Awarded : 13 Initiatives: 2 Grants Awarded: 6 Initiatives: 4 Grants Awarded: 7

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APPLICATIONS RECEIVED VS. GRANTS AWARDED by topic area

21 9 16 13 6 7 5 10 15 20 25

Disparities Environment Both

Applications Grants Funded 62% of applications funded 67% of applications funded 44% of applications funded

GRANTS AWARDED BY FUNDING MECHANISM:

RFPs, RFQs, & Program‐Directed Awards Between topic areas, the frequency of each funding mechanism in grant awards is different. 1 5 3 9 7 1 1 9 5 3 8 1 2 3 4 5 6 7 8 9 10 Disparities Environmental Both Total RFP RFQ Program‐Directed

Disparities:

• 1% RFP
• 54% RFQ
• 38% Program‐Directed

Environment:

• 83% RFP
• 17% RFQ
• 0% Program‐Directed

Both Disparities & Environment:

• 43% RFP
• 14% RFQ
• 43% Program‐Directed

Across all SRI projects, funding mechanisms are distributed more evenly.

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FUNDING

$4,196,664.00 20% $5,143,949.00 25% $11,253,042.00 55%

Total Funds Distributed by Topic Area

Disparities Environment Both Disparities & Environment $322,820.31 $857,324.83 $1,125,304.20 $‐ $200,000.00 $400,000.00 $600,000.00 $800,000.00 $1,000,000.00 $1,200,000.00 Disparities Env Both

Mean Award per Grant by Topic Area

FUNDING BY INITIATIVE

$3,043,978.00 15% $722,098.00 3% $430,588.00 2% $234,739.00 1% $4,909,210.00 24% $258,963.00 1% $5,106,704.00 25% $4,850,028.00 24% $1,037,347.00 5% Understanding racial and ethnic differerences in stage‐specific breast cancer survival Piloting an integrated approach to understanding behavioral, social, and physical environment factors and breast cancer among immigrants Demographic questions for California breast cancer research Toward the development of a California chemicals policy that considers breast cancer Making chemicals testing relevant to breast cancer Toward an ecological model of breast cancer causation and prevention Environmental causes of breast cancer across generations Environmental exposures & breast cancer in a large, diverse cohort Statistical methods to study interacting factors that impact breast cancer

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SRI Evaluation Next Steps

• Winter 2016

– Principal Investigators Survey/Interview (N=20) – Advocate Focus Group – Independent Expert Panel

• Spring 2016

– Analyses – Dissemination Mechanisms

• Report
• Infographic/Video