Prevagen Professional Training Webinar! Corrina McVay Healthcare - PowerPoint PPT Presentation

Welcome to the Prevagen Professional Training Webinar! Corrina McVay Healthcare Accounts Manager 1

Aging Concerns in the U.S. “Healthy Aging Survey” “ What is your biggest fear about aging? ”  Losing mental/brain capacity  Running out of money  Being a burden on loved ones  Restricted mobility  Heart Attack  Death of a spouse  Arthritis * Natural Marketing Institute’s 2008 Healthy Aging/Boomer General Population Survey 2

Aging Concerns in the U.S. Survey of Gen Y, Gen X, Baby Boomers, and Matures “What is your biggest fear about aging?” Losing mental/brain capacity  Running out of money  Being a burden on loved ones  Restricted mobility  Heart Attack  Death of a spouse  Arthritis * Natural Marketing Institute’s 2008 Healthy Aging/Boomer General Population Survey 3

Likelihood of Using a Memory Supplement Likely Use to Treat Likely Use to Prevent Actual Use Unmet need! 0 20 40 60 * Natural Marketing Institute’s 2008 Healthy Aging/Boomer General Population Survey 4

How Can We Close the Gap? 5

Quincy Bioscience • Quincy founded in 2004 • Discovered apoaequorin for human use - patented Headquarters - Madison, WI • Developed Prevagen in 2007 • Research-based Production - Middleton, WI 6

Apoaequorin Story (short version) • Discovered in 1962 • Luminescent calcium-binding protein (CaBP) • Biological “flashlight” • Nobel Prize for Chemistry in 2008 7

Apoaequorin Facts • Apoaequorin binds calcium ions Inouye, Satoshi, et al. “Cloning and sequence analysis of cDNA for the luminescent protein Apoaequorin.” Proceedings of the National Academy of Sciences, USA. Vol. 82 (May 1985): pp. 3154-3158. • Apoaequorin is non-toxic Blinks, John. “Use of photoproteins as Intracellular Calcium Indicators.” Environmental Health Perspectives Vol. 84 (1990): pp. 75- 81. • Apoaequorin does not interfere with other cellular functions Miller, Al, et al. “Imaging CA2+ with Apoaequorin using a photon imaging detector.” Methods in Cell Biology (1994): 40:305-338. • Apoaequorin is similar in amino acid sequence to endogenous CaBP’s Moncrief , N.D. “Evolution of EF -hand calcium- modulated proteins.” Journal of Molecular Evolution. Vol. 30, Issue 6 (1990): pp. 522- 562. 8

The “Other” Calcium • 99% of calcium in bones and teeth, 1% of calcium in our nervous system • Ionized calcium is a “ubiquitous 2 nd messenger” • Neuron signaling cascades: – Neurotransmitter release – Enzyme activation – Gene expression – Mitochondrial function • Must be tightly regulated 9

Calcium Management VGC GCC 10

Calcium Dysregulation 11

Calcium Binding Proteins Calmodulin Calbindin Calretinin Parvalbumin Iacopino Anthony M, Christakos Sylvia (1990) Specific Reduction of calcium-binding protein gene expression in aging. Proc. Natl. Acad. Sci. 12 Vol. 87, pp.4078-4082.

Cognitive Issues in Aging “…subtle changes in Ca 2+ homeostasis or in the state of various Ca 2+ -dependent processes, which occur in aging can have significant functional consequences.” 13

Society for Neuroscience 14

Prevagen Brands First & only ingredient of its kind • • 10mg or 20 mg apoaequorin 40mg apoaequorin • • Safe for any age Distributed only by Healthcare Professionals • Now Chewables • For greater memory concerns 15

Who Should Try Prevagen? • Memory lapses • Memory lapses inconvenient interfering • Family history • “Loading dose” • Younger patients • 40mg • 10mg / 20mg 16

Madison Memory Study • Double blind, placebo controlled • adults 40+ years old • 90 days, n=218 • 17

Madison Memory Study Groton Maze Learning Task Recall p=<.05 18

Madison Memory Study Groton Maze Learning Task Recall p=<.05 19

Madison Memory Study Results Statistically significant improvement over 90 days in:  Executive function  Learning  Short-term memory  Shopping list recall 20

Patient Support We provide free tools to help your patients! 21

Patient Support www.bettermemorycenter.com 22

Patient Support Awareness Education Clinic Poster Brain Health Guide 23

What Do Patients Notice? “ Over the last few months I have been taking Prevagen and I’ve experienced several improvements. Here are a few of the things I’ve noticed: Thinking/Cognition • I have more energy during the day and can concentrate longer on tasks. • I’m more fluent when I speak. I can “find” the right word more quickly. • My reading comprehension is better. • I feel like a radio that’s finely tuned; I feel “clear” headed Fatigue • I have more energy, perhaps because I’m sleeping through the night. I used to wake up several times a night to look at the calendar. • I don’t “run out of gas” during the day and rarely take a nap, (I used to nap often.) • I rarely feel tired – a huge change! ” - Shelley Schwarz, 61 yrs old (email sent to company) 24

Prevagen Results “ When people are experiencing the start of memory loss such as having difficulty remembering why they walked from one room to the next, I suggest they take Prevagen .” Henry Matick, D.O. Matick Neurology Clinic 25

Quality Production – cGMP Fermentation Freeze Drying Purification & Quality Control Encapsulation & bottling 26

Prevagen Professional • Improves Cognitive Function • Unique mechanism of action • Proven safe & well-tolerated • Contains no common allergens • Manufactured in Wis – no jellyfish harmed in the process  • Exclusive to Healthcare Professionals *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Patent pending. 27

Ordering Information: (888) 895-6463 www.PrevagenPro.com Thank You! 28

Prevagen Professional Pricing Wholesale: $54.00 ea 30ct $46.29 ea 30ct (1 Case = 7 bottles) Suggested Retail: $89.95 ea 30ct B2G1 50% off - $224.85 29