Pressure BioSciences, Inc. (OTCQB: PBIO) Discovery Starts with - - PDF document
Investor Presentation Pressure BioSciences, Inc. (OTCQB: PBIO) Discovery Starts with Sample Preparation Richard T. Schumacher President & CEO Jeffrey N. Peterson Board Chairman Vito Mangiardi, MBA Kevin A. Pollack, Esq., MBA
Discovery Starts with Sample Preparation™
Richard T. Schumacher President & CEO Jeffrey N. Peterson – Board Chairman Vito Mangiardi, MBA Kevin A. Pollack, Esq., MBA Mickey Urdea, Ph.D.
December 12, 2013
This presentation may contain forward looking statements that reflect management’s current views and opinions as to the status of the Company’s products, technology and
neither a promise nor guarantee, but involve risks and uncertainties that could cause actual results to differ materially from those anticipated or indicated. Investors are cautioned that any forward looking statements should be considered in light of such risks and uncertainties including, without limitation, those detailed in the Company’s filings with the Securities and Exchange Commission.
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Management
Boston Biomedica (CEO, Founder); Panacos Pharma (President, Co-founder); Trinity Biotech (Founding Group); CBR Labs (Gen’l Mgr) - Harvard Medical School
Avure Technologies (CSO); Flow Int’l (CSO); Grumman Aerospace; MIT (Ph.D.)
Proteome Systems; Genomic Solutions; ESA; University of Kazan (Ph.D.)
Boston Biomedica; BD; Gene-Trak Systems; Yale University (Ph.D.)
Kiva Systems; SynQor; Catamount Manufacturing; ChemDesign Corp
Board
Experienced Senior Management & Board
Consumables) for the Preparation of Samples for Scientific Research
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Molecules (e.g., genes, proteins, lipids) found in tissue (e.g., cells) or body fluids (e.g., blood) that correlate – directly of indirectly – with the presence
a disease or a disorder.
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LDL Cholesterol (coronary heart disease) PSA (prostate cancer) Her-2/neu (breast cancer) Anti-HIV (AIDS infection)
Biomarker
Importance
Estimated Market: Biomarker Discovery
WW Biomarker Market Est. to Reach $25.79B by 2016 -
2012 ASDReports 6
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Scientific research can be broken down to three key elements: sample preparation, analysis, & data reduction/interpretation “Discovery Starts with Sample Preparation”
Sample Input Quality = Sample Result Quality
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Mostly Commodity Products Through Catalogue Sales
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Barocycler™ NEP2320 PCT Sample Preparation System Barocycler™ NEP3229
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PULSE Tube MicroTubes PCT-dependent Kits
Next Gen PCT Platform: HUB Family of Barocyclers
for Multiple Research & Mfg Applications
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…the HUB for every laboratory’s high pressure needs via state-of-the-art, application specific modules & software
The Shredder SG3
Low Shear, Mechanical, Homogenization Device
Long lasting lithium rechargeable batteries Paddle for convenient pressure setting Pressure force levels: 15, 30, 45 lbs. Force Uses PCT PULSE and Shredder Tubes Heavy Duty, Robust Driver
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Selected Marquee Customers (40 of 150)
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"Protein flexibility is the new frontier in understanding protein function and regulation. The study of proteins under pressure has great ability to reveal salient features of protein flexibility, and hence provide new insights into protein function and rational drug design. In my opinion, high pressure will play a central role in the discovery process that lies ahead in the exciting field of protein science, and the PBI hardware will make major contributions to this field.” December, 2012
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“We are excited about this opportunity to collaborate with Pressure BioSciences to examine the potential applications of their PCT Platform in improving the collection of forensic evidence, particularly DNA, in several important areas of forensics…such collaborations not only provide new, effective technologies for forensic DNA testing of samples that have been difficult or unsuitable using today’s standard techniques, but can also provide new and more effective ways to reexamine old biological evidence in cold cases.”
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Professor of Forensic Science and founder of the Forensic Science Program at the University of New Haven; founder of the HC Lee Institute of Forensic Sciences; and former Commissioner of Public Safety for the State of Connecticut.
PCT Focus Area: Biomarker Discovery
…advantages of speed and quality using PCT in mass spec workflow
…improved influenza vaccine quality using PCT in mass spec workflow
…improved membrane protein identification using PCT in mass spec workflow
…improved processing of forensic (rape kit) samples using PCT
…improved membrane protein recovery in ovarian cancer studies using PCT in mass spec workflow
…improved detection of DNA in forensic samples using PCT
Cancer, Heart Disease, Inf. Diseases, Neurological Disorders, Forensics, Etc.
…evaluation of PCT in the recovery and detection of DNA in difficult forensic samples
...improved processing of FFPE (histology) samples using pressure
…improved recovery of aorta proteins from FFPE samples using PCT 1 6
Crucial to the Discovery of New Biomarkers
bottleneck
Over Current Competitive Products
Value Proposition: PCT & Biomarker Discovery
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2014 Potential Driver: Barocycler HUB880
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First Delivery Unit
Manual to High Throughput PCT
Individual (1-48) Sample Tubes Sample Tubes (wells) Simultaneously
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Automated liquid handling helps ensure accuracy and reproducibility,
eliminates repetitive tasks, and frees personnel for other activities.
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LEAP Technologies
2H 2014 Potential Driver: High Throughput PCT
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Holder for Standard “PCR” sample (9mm) plate design (up to 6 strips of 8 wells)
“Barozyme” instrument
– High pressure accelerated digestion
– Proprietary PBI 8 well strips
– 48 (2X3X8) samples
– Touch screen
Fill the sample wells and place a silicone cap
mPFwell. Up to 3 strips can be loaded on a support plate. Install retention spring clip
and support plate. Samples are now in support plate and ready to be loaded into the carrier. 1 4 3 2
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Open empty carrier. Insert support plate with samples into carrier. Latch cover and close. Load side 2 with an additional 3 strips of samples if needed. Carrier with up to 48 sample wells now ready to be placed into the pressure chamber. 1 2 3 4
Side 1 Side 2
OK to go!
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PressureFlex™ strips are the only “PCR” type strip that allow hydrostatic pressure to be easily transmitted into the sample. The samples remain leak free even under repeated 20,000 psi hydrostatic pressure cycles. Up to 6 PressureFlex™ mwell strips are nested for a total of 48 samples per carrier.
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2H 2014 Potential Driver: High Throughput PCT
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Automated liquid handling helps ensure accuracy and reproducibility,
eliminates repetitive tasks, and frees personnel for other activities.
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LEAP Technologies
Including Record Quarterly (Q3) and YTD Consumables Sales
Instrument System for Biomarker Discovery
Pressure-based Method for Lipid Analysis (Dr. Kristal – Boston)
Using PBI’s PCT Platform (Dr. McCord - FIU)
Highlighted at Int’L Protein Conference (cancer, stem cell, heart)
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Expected to Continue into 2014
New Consumables, Increased Distribution Network, and Existing Proven Products, Offer the Potential to Rapidly and Significantly Accelerate Growth in 2014 and Beyond
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