POSITIVE A highly integrated and sensitive POrous SIlicon based lab - PowerPoint PPT Presentation

Mar 12, 2024 •346 likes •434 views

POSITIVE A highly integrated and sensitive POrous SIlicon based lab on a chip for multiple quantitaTIVE monitoring of Food allergies at point of care. Keywords: Lab on a chip Rapid cost-effective multiplexed biochip integrated sample

POSITIVE A highly integrated and sensitive POrous SIlicon based lab on a chip for multiple quantitaTIVE monitoring of Food allergies at point of care. Keywords: Lab on a chip Rapid cost-effective multiplexed biochip integrated sample preparation Microfluidic Porous silicon portable label-free multiallergy diagnostic biomolecular recognition optical sensor Contact information: www.fp7positive.eu
About food allergies Food allergies – sensitization to food products Life threatening: Can provoke clinical reactions whose most severe is anaphylaxis, with respiratory and/or cardiovascular problems that might result in death. They are common in 1-2% of adults and up to 8% of children, corresponding to a serious public health problem that affects over 15 million people in Europe from infants to the elderly and its prevalence is increasing. Current diagnostic technology: Skin prick test - has its limitation. Alternatives are blood based tests, mostly using the FEIA, RAST and ELISA techniques, usually lab-based. Point-of-care devices exist; but only a few allergens at a time and give at best semi-quantitative determination. POSITIVE technology: 100µL whole blood sample Sensitization determination to 10 food allergies in 15’
Positive diagnostic procedure Developing in vitro diagnostic • Whole blood Patient sample POC platforms for food allergies readout platform (WP8) Disposable cartridge (WP7 and 9) Biosensor structures (WP 4): Sample • Polarimetric transducers preparation • Interferometric trasnducers (WP5) In porous silicon material (WP3) Sample preparation Fluidic transport User read-out for For bioassays (WP6) pre-clinical validation (WP10)
Sample preparation and transport Filter mechanism for separation of Transport to transducers serum from blood To trans- ducers
Porous silicon transducer material and mechanisms Polarimetry schematic, courtesy of University of Valencia Porous silicon sample made at UNITN, electron microscope image courtesy of University of Valencia Functionalized porous silicon with surface based immunoassays with sensing by two different transducer mechanisms
Porous silicon transducer arrays Arrays of optical transducers with surface based immunoassays

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