Portinari : A Data Exploration Tool to Personalize Cervical Cancer - - PowerPoint PPT Presentation

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Portinari : A Data Exploration Tool to Personalize Cervical Cancer - - PowerPoint PPT Presentation

Jan 12, 2024 367 likes •752 views

Portinari : A Data Exploration Tool to Personalize Cervical Cancer Screening Sagar Sen , Manoel Horta Ribeiro , Certus V&V Center and HPV Research Group, Department of Computer Science, Universidade Raquel C. de Melo

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Portinari: A Data Exploration Tool to Personalize Cervical Cancer Screening

Sagar Sen∗, Manoel Horta Ribeiro†, Raquel C. de Melo Minardi†, Wagner Meira Jr.†, Mari Nygård‡

∗ Certus V&V Center and HPV Research Group,
 † Department of Computer Science, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, ‡ HPV Research Group, Cancer Registry of Norway, Oslo, Norway 1

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Software’s Impact in Societal Processes

Through which means societies organize themselves?

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Software’s Impact in Societal Processes

politics Through which means societies organize themselves?

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Software’s Impact in Societal Processes

politics Through which means societies organize themselves?

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Software’s Impact in Societal Processes

politics Through which means societies organize themselves? social bonds

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Software’s Impact in Societal Processes

politics Through which means societies organize themselves? social bonds

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Software’s Impact in Societal Processes

politics Through which means societies organize themselves? social bonds labour

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Software’s Impact in Societal Processes

politics Through which means societies organize themselves? social bonds labour

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Self-organizing vs. Centralized

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Self-organizing vs. Centralized

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Self-organizing vs. Centralized

vs

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Self-organizing vs. Centralized

vs

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Norway’s Screening Program

Cytology

Unsatisfactory 1 -3 months

HPV-test

HPV +ve 6 - 12 months HPV Normal 3 years

New Cytology and HPV- test

ASC-US/LSIL Immediately Cytology Normal 3 years

Colposcopy with biopsy

AGUS/ASC-H/HSIL/ACIS/Ca Immediately HPV Normal and Cytology Normal/ASC-US 3 years HPV +ve Immediately HPV Normal and LSIL or LSIL/AGUS/ ASC-H/ACIS/Ca Immediately Entry intro screening program 25-69 years of age Definitions ACIS: Adenocarcinoma in situ AGUS: Atypical glandular cells of undetermined significance, under cell. ASC-H: Irregular squamous cells with changes suggestive of high grade lesion, but do not meet all the criteria for diagnosis ASC-US: Irregular squamous cells with abnormalities of uncertain significance Ca: All types of cancer Cytology: Test to look at abnormal cells HPV: Humanpapillomavirus HSIL: High-grade squamous intraepithelial lesion LSIL: Low-grade squamous intraepithelial lesion

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Triage Algorithm Screening Exams Invitation and Reminders

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Triage Algorithm Screening Exams Invitation and Reminders

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Triage Algorithm Screening Exams Invitation and Reminders Verification and Validation

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Triage Algorithm Screening Exams Invitation and Reminders Verification and Validation

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Triage Algorithm Screening Exams Invitation and Reminders Verification and Validation

Statistics by epidemiologists

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Triage Algorithm Screening Exams Invitation and Reminders Verification and Validation

Statistics by epidemiologists Data exploration and visualization

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What data?

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What representation?

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Querying

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Portinari Flow Diagrams of Future Paths

The flow diagram starts where the query patterns ends, showing Each layer represents the distribution of diagnosis n exams into the future. Hovering over the edges or nodes of the graph shows stats! Portinari allows two charts to be displayed side by side!

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Explorations

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Exploring effects of screening guidelines

Cytology Normal Cytology Normal 3-4 years

What happens after 3 years to this cohort?

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261133 individuals 230,331 individuals 39 individuals

Next Diagnosis in 3 years

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280572 individuals 193543 individuals

Next Two Diagnoses

Did not return

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Exploring existing screening guidelines

Cytology Normal Cytology Normal 3-4 years

What if women come back in the next 30 days?

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4337 individuals

Cytology not good enough for some?

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Cytology Normal HPV +ve next exam

Comparing two scenarios in the triage algorithm Come back within 1 year Come back in 1 to 2 years vs. (Guideline)

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Returned in 1 -2 years Returned within 1 year

13297 individuals 278 individuals (19) 6.83% HPV +ve (227) 1.61% HPV +ve

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Conclusion

➤ Alternative way of verifying and validating paths

taken by people in a socio-technical system.

➤ Use of easy-to-query graph database. ➤ Generalizable to event-driven data. ➤ Generation hypothesis for further statistical

investigation.

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https://github.com/manelhr/portinari/ homepages.dcc.ufmg.br/~manoelribeiro/ manoelribeiro

Questions?

Manoel Horta Ribeiro

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https://github.com/manelhr/portinari/ homepages.dcc.ufmg.br/~manoelribeiro/ manoelribeiro

Questions?

Manoel Horta Ribeiro

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