Pes$cides, endocrine disruptors and a look toward the future. Pete - - PowerPoint PPT Presentation

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Pes$cides, endocrine disruptors and a look toward the future. Pete - - PowerPoint PPT Presentation

Aug 21, 2023 189 likes •492 views

Pes$cides, endocrine disruptors and a look toward the future. Pete Myers, Ph.D. Pete Myers, Ph.D. Envir Environmental Health Sciences onmental Health Sciences and and Car Carnegie Mellon University negie Mellon University Environmental Health

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SLIDE 1

Environmental Health Sciences

Pes$cides, endocrine disruptors and a look toward the future.

Pete Myers, Ph.D. Pete Myers, Ph.D. Envir Environmental Health Sciences

  • nmental Health Sciences

and and

Car Carnegie Mellon University negie Mellon University

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SLIDE 2

Environmental Health Sciences

Asthma Hormone-related cancers

Learning disabilities Pre-term birth

Diabetes

Degenerative diseases

Infertility

Autism

Fibroids

Heart disease

Autoimmunity

Endometriosis

Obesity

polycystic ovaries

ADHD

Allergies

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SLIDE 3

Environmental Health Sciences

19 Feb 2013: WHO – UNEP report

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Environmental Health Sciences

2013 WHO-UNEP report

Many endocrine related disorders are on the rise, far too rapidly to be a change in gene frequency. ~800 chemicals in common use are known to disrupt endocrine function. Human and wildlife exposure is ubiquitous. Numerous laboratory, wildlife and epidemiological studies are consistent with endocrine disruption impacts on human health. Disease risk due to EDCs may be significantly underestimated. Significant opportunities for disease prevention by reducing exposures may be within reach.

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Environmental Health Sciences

Costly

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Environmental Health Sciences

It simply is not reasonable to assume a chemical is safe until proven otherwise. Transgenerational effects of EDCs mean that even if a chemical is removed from use, its imprints on the exposed individual’s DNA may persist for generations and possibly forever. In 2015, there is far more conclusive evidence about whether, when, and how EDCs perturb endocrine systems, including in

  • humans. Thus, it is more necessary than ever to minimize

further exposures, to identify new EDCs as they emerge, and to understand underlying mechanisms. Emerging evidence ties endocrine-disrupting chemical exposure to two of the biggest public health threats facing society – diabetes and obesity

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SLIDE 7

Environmental Health Sciences

  • 1. Low doses matter a lot
  • 2. Events in the womb don’t stay in the womb
  • 3. Mixtures are ubiquitous and amplify effects

Revolution in science

…and non-monotonicity is common

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SLIDE 8

Environmental Health Sciences

2.5 parts per billion of atrazine

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Environmental Health Sciences

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Environmental Health Sciences

0.1 1 100 1,000,000 10,000 PPB

Safe short term

Hayes et al. 2002

ATRAZINE

This result Recommended application Run-off Streams Surface water Safe for drinking water Rain

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SLIDE 11

Environmental Health Sciences

  • 1. Low doses matter a lot
  • 2. Events in the womb don’t stay in the womb
  • 3. Mixtures are ubiquitous and amplify effects

Revolution in science

…and non-monotonicity is common

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SLIDE 12

Environmental Health Sciences

Kidneys Bladder Testes Control

Bell Jones et al. 2007 T&E2 Capsule T&E2 Capsule

Bladder Kidneys Testis BPA

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SLIDE 13

Environmental Health Sciences

  • 1. Low doses matter a lot
  • 2. Events in the womb don’t stay in the womb
  • 3. Mixtures are ubiquitous and amplify effects

Revolution in science

…and non-monotonicity is common …or create them out of nothing

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SLIDE 14

Environmental Health Sciences

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SLIDE 15

Environmental Health Sciences

Glyphosate-based herbicides

Told they were safe Ubiquitous use

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Environmental Health Sciences

Glyphosate-based herbicides

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Environmental Health Sciences

Glyphosate-based herbicides

Independent assessments… Inconvenient data…

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SLIDE 18

Environmental Health Sciences

Glyphosate-based herbicides

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SLIDE 19

Environmental Health Sciences

RoundUp is an EDC

Huge implica$ons For health For policy For GMOs

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SLIDE 20

Environmental Health Sciences

  • 1. Small number of exposures reduced
  • 2. Small number of significant public health wins

That revolution in science…

  • 3. Against an onslaught of chronic disease epidemics
  • 4. And the continued use and de novo synthesis of

thousands of chemicals about which we know almost nothing.

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SLIDE 21

Environmental Health Sciences

  • 1. Tools agencies use for establishing safety are
  • utdated, mostly irrelevant and based on false

assumptions

What’s wrong with that picture?

  • 2. Laws and regulations outdated
  • 3. They stay that way because of the financial stakes

and the effectiveness of manufactured doubt

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SLIDE 22

Environmental Health Sciences

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SLIDE 23

Environmental Health Sciences

Non-monotonicity of tamoxifen

Welshons, in Vandenberg et al. 2012

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SLIDE 24

Environmental Health Sciences

  • 1. Tools agencies use for establishing safety are
  • utdated, mostly irrelevant and based on false

assumptions

What’s wrong with that picture?

  • 2. Laws and regulations outdated
  • 3. They stay that way because of the financial stakes

and the effectiveness of manufactured doubt

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SLIDE 25

Environmental Health Sciences

  • 1. Tools agencies use for establishing safety are
  • utdated, mostly irrelevant and based on false

assumptions

What’s wrong with that picture?

  • 2. Laws and regulations outdated
  • 3. They stay that way because of the financial

stakes and the effectiveness of manufactured doubt

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SLIDE 26

Environmental Health Sciences

  • 1. The science grows ever stronger

Where’s the good news?

  • 2. The medical community is getting on board
  • 3. Consumers are demanding safer materials
  • 4. We have the science to help chemists make those

safer materials

  • 5. The states are improving policies; so is Europe
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SLIDE 27

Environmental Health Sciences

Much more is underway than toxification of the planet

Looking forward: a caution

These planetary forces are growing And their interactions are force multipliers

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SLIDE 28

Environmental Health Sciences

What happens when shit hits the FAN?

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SLIDE 29

Environmental Health Sciences

Asthma Hormone-related cancers

Learning disabilities Pre-term birth

Diabetes

Degenerative diseases

Infertility

Autism

Fibroids

Heart disease

Autoimmunity

Endometriosis

Obesity

polycystic ovaries

ADHD

Allergies