PARENCHIMA WG3: Position paper Nicholas M Selby, Peter J - - PowerPoint PPT Presentation

PARENCHIMA WG3: Position paper

Nicholas M Selby, Peter J Blankes7jn, Peter Boor, Chris7an Combe, Kai-Uwe Eckardt, Eli EikeAord, Nuria Garcia-Fernandez, Xavier Golay, Isky Gordon, Nicolas Grenier, Paul D Hockings, Jens Jenson, Jaap A Joles, Philip A Kalra, Bernhard K Krämer, Patrick B Mark, Iosif A Mendichovszky, Olivera Nikolic, Aghogho Odudu, Albert CM Ong, Alberto Or7z, Menno Pruijm, Giuseppe Remuzzi, Jarle Rørvik, Sophie de Seigneux, Roslyn J Simms, Janka Sla7nska, Paul Summers, Maarten W Taal, Harriet C Thoeny, Jean-Paul Vallée, Marcos Wolf, Anna Caroli, Steven Sourbron

Aims of position paper

• Arose from Bergamo mee7ng
• Enunciate the important clinical ques7ons that MRI

could be used to answer, to direct future strategy in terms of study design and funding applica7ons

• To agree principles around important aspects of

study design

• To publicise the group and our aims

Manuscript

• Two sec7ons
• Discussion of key clinical ques7ons
• Renal MRI must cross two transla7onal gaps
• Aiming to establish technical, biological and clinical valida7on,

then move to clinical u7lity and health technology assessment

• Subheadings:
• Diagnos(c biomarkers: diagnosis and classifica(on of disease
• Prognos(c biomarkers: predic(ng disease progression
• Predic(ve biomarkers: pa(ent selec(on for treatment
• Monitoring biomarkers: response to treatment
• Safety biomarkers: detec(ng drug toxicity
• Series of 14 recommenda7ons

Recommendations