ON GOING RESEARCH IN THE COLLEGE HEALTH SCIENCES, UNIVERSITY OF - - PowerPoint PPT Presentation
ON GOING RESEARCH IN THE COLLEGE HEALTH SCIENCES, UNIVERSITY OF NAIROBI A presentation by: Prof. Isaac O. Kibwage Principal, College of Health Sciences (CHS), University of Nairobi University of Nairobi ISO 9001:2008 1 Certified
University of Nairobi ISO 9001:2008 1 Certified http://chs.uonbi.ac.ke
University of Nairobi ISO 9001:2008 2 Certified http://chs.uonbi.ac.ke
College
Health Sciences is the leading tertiary healthcare training centre in Kenya. Declared a Centre of Excellence in the East Africa Community in 2014 It is situated in Kenyatta National Hospital (KNH) Campus about four (4) kilometers from Nairobi Central Business District (NCBD) It offers 79 programmes in medicine, pharmacy, nursing, dentistry and public health are
at the undergraduate and postgraduate levels.
University of Nairobi ISO 9001:2008 3 Certified http://chs.uonbi.ac.ke
University of Nairobi ISO 9001:2008 4 Certified http://chs.uonbi.ac.ke
University of Nairobi ISO 9001:2008 5 Certified http://chs.uonbi.ac.ke
University of Nairobi ISO 9001:2008 6 Certified http://chs.uonbi.ac.ke
University of Nairobi ISO 9001:2008 7 Certified http://chs.uonbi.ac.ke
1. Institute of Tropical and Infectious Diseases (UNITID) (2004) 2. Kenya Aids Vaccine Initiative ‐ Institute of Clinical Research (KAVI‐ICR) (2013) 3. The East African Kidney Institute (EAKI) (2014)
Genital Mutilation (ACCAF) (2013)
University of Nairobi ISO 9001:2008 8 Certified http://chs.uonbi.ac.ke
University of Nairobi ISO 9001:2008 9 Certified http://chs.uonbi.ac.ke
1. Declared a Regional Centre of Excellence by a General Purpose Committee of the EA Legislative Assembly with a mandate to train Health Professionals.
MGDS Trust Fund in recognition of the contribution for combating HIV/AIDS and other diseases as one of the pillars in the UN Millennium Development Goals in Kenya
University of Nairobi ISO 9001:2008 10 Certified http://chs.uonbi.ac.ke
University of Nairobi ISO 9001:2008 11 Certified http://chs.uonbi.ac.ke
I. 80 high end programs regulated by various professional statutory boards PhDs/MD ‐ 21 Masters ‐ 41 Bachelors ‐ 8 Diplomas ‐ 5 II. Fellowships ‐ 5
University of Nairobi ISO 9001:2008 12 Certified http://chs.uonbi.ac.ke
Kenyatta National Hospital (KNH) Complex , about 4 km from Nairobi Central Business District
Public Health, UNITID and CHIVPR at KNH
Preclinical departments located at Chiromo Campus School of Dental Sciences and University Dental Hospital in Upper hill, Nairobi
University of Nairobi ISO 9001:2008 13 Certified http://chs.uonbi.ac.ke
University of Nairobi ISO 9001:2008 14 Certified http://chs.uonbi.ac.ke
COUNTRY No. COUNTRY No. Benin 1 Ivory Coast 1 Botswana 4 Korea 1 Burundi 5 Liberia 1 Cameroon 1 Malawi 18 Canada 3 Mali 1 Congo DRC 6 Mauritania 3 Cote D’Ivore 1 Mozambique 5 Eritrean 1 Nepal 1 Ethiopia 6 Nigeria 7 Ghana 1 Pakistan 1 India 3 Rwanda 31
University of Nairobi ISO 9001:2008 15 Certified http://chs.uonbi.ac.ke
COUNTRY NO COUNTRY NO Sierra Leone 2 USA 23 Somalia 20 Zambia 13 South Sudan 49 Zimbabwe 1 Sudan 1 Zaire 1 Swaziland 2 Tanzania 21 Uganda 7
Total International Students
140
Total Countries
33
University of Nairobi ISO 9001:2008 16 Certified http://chs.uonbi.ac.ke
I. Total Academic Staff ‐ 432 Professors ‐ 53 Associate Professors ‐ 66 Senior Lecturers ‐ 86 Lecturers ‐ 166 Assistant Lecturers ‐ 2 Tutorial Fellows ‐ 56 Part Time Lecturers ‐ 1 Graduate Assistants ‐ 2 II. Technical & Administrative ‐ 328
297
University of Nairobi ISO 9001:2008 17 Certified http://chs.uonbi.ac.ke
KNH (National Referral and Official Teaching Hospital) and Mathari, Pumwani, Tigoni and Mbagathi Hospitals Nairobi Surgical Skills Centre Multipurpose Skills and Teaching Laboratories Enhanced Level III Bio‐containment Laboratory Telemedicine and Telepathology studios
University of Nairobi ISO 9001:2008 18 Certified http://chs.uonbi.ac.ke
WHO Regional Training Centre for Ophthalmology Main Lecture Theatres (1*500 pax, 1*350 pax, 3*150 pax, 1*100 pax, 2*40 pax) Laboratories (1*350 pax) Seminar Rooms Decentralized sites for students attachment
University of Nairobi ISO 9001:2008 19 Certified http://chs.uonbi.ac.ke
1. AIC Litein Hospital
University of Nairobi ISO 9001:2008 20 Certified http://chs.uonbi.ac.ke
46 active collaborations including:
Teaching hospitals (Pumwani, Mathari, KNH) Research partners (KEMRI, NACOSTI, Institute of Primate Research, AMREF, Wellcome Trust etc.) Universities (Maryland, Baltimore, USA; Washington, Seattle, USA; Manitoba, Canada; Oxford, UK; Ludwig‐ Macmillan, Munich, Germany etc.)
University of Nairobi ISO 9001:2008 21 Certified http://chs.uonbi.ac.ke
CHS endeavors to attract funding, conduct research and publish research findings in relevant journals. Activities span from basic to applied and operational research with strong platforms for clinical trials, traditional medicine, quality assurance of medicines, vaccine developments and Tropical and Infectious diseases.
Research Output/Activities (2011‐2015)
Item 2011/2012 2012/2013 2013/2014 2014/2015 Scientific Papers 338 315 324 422 Research Funding (USD) 15.6M 16.3M 16.6M 17.7M
University of Nairobi ISO 9001:2008 22 Certified http://chs.uonbi.ac.ke
Office of Research and Grants Promotion and Support (ORePS)
Established in March 2014 to provide support in research administration and grants management to faculty, researchers and students to: Provide pre‐award and post‐award services Effectively manage research and grant programs Build capacity
research related courses Ensure compliance with UoN, Government and funding agencies policies, regulations and guidelines
University of Nairobi ISO 9001:2008 23 Certified http://chs.uonbi.ac.ke
Central Province Response Integration Strengthening and Sustainability Project (CRISSP) International Centre for AIDS Care and Treatment Programs (ICAP) Most At Risk Populations (MARPS) Partnership for Advanced Care and Treatment‐ Centre of Excellence (PACT‐CoE) Partnership for Advanced Clinical Education (PACE) Pre‐Exposure Prophylaxis Study (PrEP)
Partnership for Innovative Medical Education in Kenya (PRIME‐K) Kenya AIDS Vaccine Initiative ‐ Institute of Clinical Research (KAVI‐
ICR)
University of Nairobi ISO 9001:2008 24 Certified http://chs.uonbi.ac.ke
Partnership for Innovative Medical Education in Kenya (PRIME‐K) Kenya AIDS Vaccine Initiative ‐ Institute of Clinical Research (KAVI‐
ICR)
8 PhD and 7 Masters students supported through KAVI to pursue research related programmes
University of Nairobi ISO 9001:2008 25 Certified http://chs.uonbi.ac.ke
Kenya AIDS Vaccine Initiative ‐ Institute of Clinical Research (KAVI‐ ICR)
Linked Maternal Newborn and Child Health (LINKED MNCH) Endometriosis Research: Characterization
the TGF‐BETA Signalosome and
TGF‐BETA Dependent Endometrial Cell Proliferation
LINKED Mental Health
African Institute of Biomedical Science and Technology Laboratory (AiBST)
University of Nairobi ISO 9001:2008 26 Certified http://chs.uonbi.ac.ke
Centre for HIV Prevention and Research (CHIVPR) Established as a successor to the STD/HIV/AIDS Control Project in Kenya as an intervention targeting the STD/HIV/AIDS vulnerable groups more specifically Female sex workers and their clients in Kenya. Empowered the MARPs in the two provinces thus improving their health seeking behavior especially reporting for post rape care or after condom burst (PEP) IMPACT: Contributed towards “zero HIV transmission in Kenya” as evidenced in second to fourth quarter 2014‐2015. Transmission incidences dropped from 5.1 %, 4.4% and 3.0% respectively among female sex workers.
University of Nairobi ISO 9001:2008 27 Certified http://chs.uonbi.ac.ke
Provides support to targeted health facilities and communities in Central Kenya (Kiambu and Kirinyaga), to achieve and maintain universal access to HIV prevention, care and treatment services through a systems strengthening approach. IMPACT: Improved HIV prevention, care and treatment as a result of enhanced capacity of health workers Strengthened laboratory and other health systems in those counties through the developed standard operating procedures.
University of Nairobi ISO 9001:2008 28 Certified http://chs.uonbi.ac.ke
Supported comprehensive HIV prevention, care and treatment, prevention of mother‐to‐child transmission (PMTCT), integrated TB/HIV care Supported cervical cancer care and nurses training by UoN in Eastern and Nyanza provinces IMPACT: Shaped national and international guidelines on the treatment of HIV, tuberculosis, malaria, and other health areas Improved quality of cervical cancer screening services in model facilities and strengthened linkages and referrals between satellite and model facilities
University of Nairobi ISO 9001:2008 29 Certified http://chs.uonbi.ac.ke
An international research hub which focuses on four themes: Non‐Communicable Diseases, Communicable Diseases, Clinical Trials and Knowledge Translation. IMPACT: Strengthened the capacity within Sub Saharan Africa in the field of vaccines and immunization. Extended community
University of Nairobi ISO 9001:2008 30 Certified http://chs.uonbi.ac.ke
Conducted 11 HIV vaccine studies in 14 years Increased female enrolment from 11% (2002) to 56% (HIVCORE) Achieved study participant retention rate of 94 – 100% Exploring different vaccination strategies
Use of replicating and/or non‐human viral vectors Integration of mucosal sampling into vaccine studies
University of Nairobi ISO 9001:2008 31 Certified http://chs.uonbi.ac.ke
Has improved the quality of medical education; extended the reach of medical training outside Nairobi; increased retention of UON faculty by providing opportunities to pursue clinical or applied research and Support for the UON Research Structures. IMPACT: Retained graduates and faculty in areas where they are most needed
Kenya
clinical mentorship and role models in non‐tertiary and primary care settings.
University of Nairobi ISO 9001:2008 32 Certified http://chs.uonbi.ac.ke
Increased the quantity, quality and capacity of health care workers
in Kenya Increased capacity of UoN faculty to conduct locally relevant research
Support ( ORePS)
research
University of Nairobi ISO 9001:2008 33 Certified http://chs.uonbi.ac.ke
Supports research and programs in non‐tertiary Ministry of Health (MOH) facilities using a multi‐disciplinary approach. It’s main research focus is identification of gaps and opportunities for improving adherence to guidelines targeting causes of mortality in children and mothers. It implemented a simulation program in Emergency obstetric care and newborn resuscitation (PRONTO) IMPACT: Immediate postpartum contraceptive implants: Overall uptake of the implants was 50.3% contrary to existing belief regarding it’s low usage. As a result, use of the contraceptive implants has dramatically improved across MOH facilities Use of caregivers to monitor intake of oral rehydration solution (ORS): Frequency of hospitalization of children presenting with diarrhoea reduced by 63%
University of Nairobi ISO 9001:2008 34 Certified http://chs.uonbi.ac.ke
Building capacity to address mental health concerns across Kenya while creating a strong, central core of faculty, students and support staff at the University of Nairobi IMPACT: Trained faculty from psychiatry, psychology, nursing and public health in mental health research methodology and implementation science and providing them with tools needed to be effective mentors. Trained postgraduates in mental health research through coursework and mentored research projects that take an implementation science approach. Established a mental health research resource centre
University of Nairobi ISO 9001:2008 35 Certified http://chs.uonbi.ac.ke
Implemented a comprehensive HIV prevention, care and treatment program in order to facilitate the Ministries of Medical Services and Public Health and Sanitation control the spread of HIV, and rapidly scale up HIV services within government run health facilities in Nairobi. IMPACT: Supported NASCOP in strengthening HIV training at pre‐service (universities and training colleges), in‐service and laboratory institutions.
University of Nairobi ISO 9001:2008 36 Certified http://chs.uonbi.ac.ke
Supported Kenya’s 6 public universities to deliver HIV education that is based on core competencies; developed and implemented an integrated competency‐based in‐service HIV training and developed capacity within universities, medical training colleges, and MOH health facilities to provide structured and practical high quality training in HIV laboratory services. IMPACT: Transferred technical capacity to Kenyan health care professionals with the intention of enabling local partners to fully manage programs supported by the United States Government
University of Nairobi ISO 9001:2008 37 Certified http://chs.uonbi.ac.ke
A multi‐site randomized trial to assess the efficacy of
sexual transmission of HIV among HIV‐serodiscordant couples. IMPACT: This study established that use of the drug Truvoda Prophylactical reduced infection incidences by over 90% among the MARPS.
University of Nairobi ISO 9001:2008 38 Certified http://chs.uonbi.ac.ke
AiBST trained healthcare professionals in the private sector
treatment, monitoring and management of HIV/AIDS.
IMPACT:
Improved capacity targeting medical doctors, nurses, pharmacists and medical laboratory technologists working at missionary hospitals/clinics, mining, and farming healthcare centres and privately
hospitals & clinics in pharmacogenetics research
University of Nairobi ISO 9001:2008 39 Certified http://chs.uonbi.ac.ke
Reduction of HIV incidences and Government of Kenya has formally included PrEP in our national HIV prevention revolution road map up to the Year 2030 Created employment opportunities through grants Improved Quality of Care Reduction in new cases of HIV infection as evidenced in second to fourth quarter, 5.1 %, 4.4% and 3.0% respectively among female sex workers Noted improvement in the health seeking behavior especially reporting for post rape care or after condom burst (PEP) Facilitated provision and fitting of > 20,000 hearing aids in partnership with Starkey Foundation, USA.
University of Nairobi ISO 9001:2008 40 Certified http://chs.uonbi.ac.ke
Quality assurance of medicines Increased uptake of the contraceptive implants was 50.3% contrary to existing belief regarding it’s low usage. Frequency of hospitalization of children presenting with diarrhoea reduced by 63% Community outreach Promotive (awareness on health issues) Preventive (HIV vaccine development, cervical & breast cancer screening) Treatment (eye surgery, cleft lip/palate surgery) Policy and Practice
Development of guidance and policy document on Adolescent research Development of the Ministry of Health 5‐year strategic framework for HIV/AIDS Support NACC in developing budget to fund 5‐year research priorities
University of Nairobi ISO 9001:2008 41 Certified http://chs.uonbi.ac.ke
University of Nairobi ISO 9001:2008 42 Certified http://chs.uonbi.ac.ke
University of Nairobi ISO 9001:2008 43 Certified http://chs.uonbi.ac.ke
University of Nairobi ISO 9001:2008 44 Certified http://chs.uonbi.ac.ke
University of Nairobi ISO 9001:2008 45 Certified http://chs.uonbi.ac.ke
University of Nairobi ISO 9001:2008 46 Certified http://chs.uonbi.ac.ke
University of Nairobi ISO 9001:2008 47 Certified http://chs.uonbi.ac.ke
University of Nairobi ISO 9001:2008 48 Certified http://chs.uonbi.ac.ke
University of Nairobi ISO 9001:2008 49 Certified http://chs.uonbi.ac.ke
University of Nairobi ISO 9001:2008 50 Certified http://chs.uonbi.ac.ke
University of Nairobi ISO 9001:2008 51 Certified http://chs.uonbi.ac.ke
University of Nairobi ISO 9001:2008 52 Certified http://chs.uonbi.ac.ke
University of Nairobi ISO 9001:2008 53 Certified http://chs.uonbi.ac.ke
University of Nairobi ISO 9001:2008 Certified http://chs.uonbi.ac.ke
University of Nairobi ISO 9001:2008 55 Certified http://chs.uonbi.ac.ke