SLIDE 2 5/30/2019 2
FATIGUE AS A COMPLEX PHENOMENON
- Subjective, general state of recurrent and profound exhaustion that
is not alleviated by sleep or rest2-4
- One of most prevalent and debilitating MS symptoms
- Despite some efficacious treatments, mechanisms are poorly-
understood5,6
- Inability to sustain performance during objective physical and
cognitive tasks undertaken over time (i.e., objectively-measured fatigue)7-9
- Specific consequence of several neurological disorders, including MS7,9
- No correlation with generalized measures of subjective fatigue in MS10,11
2 Krupp et al., 2003; 3 Andreasen et al., 2018; 4 Kluger et al., 2013; 5 Vucic et al., 2010; 6 MacAllister et al., 2005; 7 Chaudhuri et al., 2004; 8 Holtzer et al., 2010; 9 Chaudhuri & Behan, 2000; 10 DeLuca, 2005; 11 Bailey et al., 2007
OBJECTIVELY-MEASURED FATIGUE IN MS
- May occur in both physical and cognitive domains among
persons with MS
- Based on the inability of persons with MS to sustain performance over the
duration of physical and cognitive tasks12-16
- Associated with physiological deconditioning and suboptimal
brain activation in persons with MS17-19
- Objectively-measured physical and cognitive fatigue not
exclusive to MS; also common and debilitating in older adults20-22
12 Leone et al., 2016; 13 Calay et al., 2012; 14 Walker et al., 2012; 15 Morrow et al., 2015; 16Holtzer et al., 2013; 17 Ramari et al., 2018; 18 DeLuca et al. ,2008; 19 Dobryakova et al., 2018; 20 Simonsick et al., 2014; 21 Moreh et al., 2010; 22 Egerton et al., 2016;
