NIH Research Opportunities in Biocomputing and Bioinformatics Peter - - PowerPoint PPT Presentation

NIH Research Opportunities in Biocomputing and Bioinformatics

Peter M. Lyster, Ph.D. (301) 435 1256 Lysterp@csr.nih.gov Center for Scientific Review National Institutes of Health

NIH CSR

The National Institutes of Health

NCCAM NHLBI NICHD NIGMS NCMHD NIA NIDA NIMH NCI NIAAA NIDCD NINDS NCRR NIAID NIDCR NINR NEI NIAMS NIDDK NLM NHGRI NIBIB NIEHS CSR

NIH CSR

Research Grants 71%

NIH Budget FY 2001

Total – $20.3 Billion

(Estimate)

Over 80% of NIH funds support extramural research. Over 80% of NIH funds support extramural research. Research Training 3% R&D Contracts 7% Intramural Research 10% All Other 6% Research Mgmt. & Support 3%

NIH CSR

How to Get Funded?

• Idea for research involving biomedicine
• Form collaboration?
• Contact Program Officer at Institute or Center
• Submit grant (use PHS 398)
• Referral and Initial Review at Center for Scientific

Review (CSR): Study Sections.

• Final Review by Program and Councils
• Decision by Program Staff at Institute or Center

NIH CSR

Common Problems in Applications

• Lack of new or original ideas
• Absence of an acceptable scientific rationale
• Lack of experience in the essential methodology
• Questionable reasoning in experimental approach
• Uncritical approach
• Diffuse, superficial, or unfocused research plan
• Lack of sufficient experimental detail
• Lack of knowledge of published relevant work
• Unrealistically large amount of work
• Uncertainty concerning future directions

NIH CSR

Information on the World Wide Web Review: Selected Sites of Interest

• National Institutes of Health (http://www.nih.gov)

– Office of Extramural Research (http://www.nih.gov/grants/oer.htm) – Grants Policy (http://www.nih.gov/grants/policy/policy.htm)

• Center for Scientific Review (http://www.csr.nih.gov)

– Referral and Review (http://www.csr.nih.gov/refrev.htm) – Overview of Peer Review Process (http://www. csr.nih.gov/review/peerrev.htm) – CSR Study Section Rosters (http://www.csr.nih.gov/committees/rosterindex.asp) – NIH Peer Review Notes (http://www.csr.nih.gov/prnotes/prnotes.htm)

NIH CSR

Trans-NIH Bioinformatics Research Opportunities

• Coordinated by the BISTI Consortium

(BISTIC)

• Consists of representatives of all NIH

institutes, centers, and offices

• Established June 2000
• Administered by the NIGMS
• Web site-

http://grants.nih.gov/grants/bistic/bistic/htm

NIH CSR

Bioinformatics Research Areas

• Data collection
• Archiving large data sets
• Modeling, simulation, and analysis
• Telemedicine
• Platform-independent translational tools for

data exchange

• Data visualization

NIH CSR

Bioinformatics Research Areas

• Databases, querying approaches, and

information retrieval

• Computing algorithms and new methods for

social science research

• Interoperability
• Web-based tools for data sharing
• Robotics and remote control systems

NIH CSR

BISTIC Activities - Research

• Planning Grants for National Programs of

Excellence in Biomedical Computing (NPEBC) (P20)

• Innovations in Biomedical Informatics

Science and Technology (R21/R33)

• SBIR/STTR Biomedical Computing

Awards (PA-00-118) (R41, R42, R43, R44)

NIH CSR

NPEBC Planning Grants (PAR-00-102)

• Support planning of programs (P20) – develop

collaborations, plan internal programs, recruit expertise, develop courses, etc.

• Up to 3 years
• No annual budget limit
• Applications due November 27, March 27, and

July 27 through 2002

• 12 Awards (Average = $230 k)

NIH CSR

NPEBC Objectives

• Conduct bioinformatics research that

advances biology and medicine

• Develop informatics tools for biomedical

research

• Train a new generation of biomedical

computer scientists

• Establish collaborations between the

biomedical and computational communities

NIH CSR

R21/R33 Research Awards (PAR-00-117)

• Phased Innovation Awards
• Can apply for R21/R33 package or only R33

award

• R21 – Developmental – 2 years - $100 k per year

limit

• R33 – Research – 3 years – no limit
• Package – 4 years – no limit
• Application deadlines – November 27, March 27,

and July 27 through 2002

• 16 Awards (Average = $ 240 k)

NIH CSR

Trans-NIH Bioengineering Research Opportunities

• Bioengineering Consortium (BECON)
• Consists of representatives of all NIH

institutes, centers, and offices and other Federal agencies

• Established February 1997
• Administered by the NIBIB
• Web site –

http://www.nih.gov/grants/becon/becon.htm

NIH CSR

Bioengineering Research

• Multi-disciplinary
• Partnership and collaboration
• Technology- or needs-driven

NIH CSR

Trans-NIH BME Research Opportunities

• Bioengineering Research Grants (BRG’s)
• Bioengineering Research Partnerships

(BRP’s)

• SBIR/STTR Bioengineering Awards

NIH CSR

Bioengineering Research Grants

• R01 awards – Apply basic bioengineering design-

directed or hypothesis-driven research to an important biomedical area.

• Aimed at single or small groups of researchers
• Applications due on R01 receipt dates – February

1, June 1, October 1

• 90 Awards (Average = $280 k)

NIH CSR

Bioengineering Research Partnerships

• R01 awards – special review
• Requires a multi-disciplinary research team

applying an integrative, systems approach to address a biomedical problem

• Deadlines: January 24 and August 12, 2002
• 54 Awards (Average = $980 k)

NIH CSR

NIBIB Mission

“… to improve health by promoting fundamental discoveries, design and development, and translation and assessment of technological capabilities. … The Institute coordinates with … other agencies and NIH institutes to support… research and facilitate the transfer of such technologies to medical applications.”

NIH CSR

To support its mission, the NIBIB will -

• Support imaging and bioengineering

research and training

• Partner with NIH institutes and centers to

translate fundamental discoveries into biomedical research applications

• Coordinate with other government agencies

to translate cross-cutting technological developments into biomedical applications

NIH CSR

What’s different?

• Focus on “multi-disciplinary” and

“partnerships”

• Design- and needs-driven research vs.

hypothesis-driven

• Translation of enabling technologies to

biomedical applications

• Multi-disciplinary review
• Inter-agency and inter-institute

NIH CSR

Contact a NIH IC rep before preparing your application

• Tell the rep about your project
• Ask if the IC would encourage submittal
• If so, is there a better mechanism?
• If not, other IC interest?
• Suggestions for project
• Include contact in cover letter
• Greater than $500 k direct cost approval

NIH CSR

Who are NIH BME and BI IC Representatives?

• BECON and BISTIC members
• Senior technical and program staff
• Available on the Internet at:

http://grants.nih.gov/grants/becon/becon_co ntacts.html

• r

http://grants.nih.gov/grants/bistic/bistic_con tacts.cfm

NIH CSR

CRISP (Computer Retrieval of Information on Scientific Projects) http://crisp.cit.nih.gov/ is a searchable biomedical database of federally-supported proposed research conducted at universities, hospitals, and other research institutions. NIH Grants Guide http://grants1.nih.gov/grants/guide/ NSF https://www.fastlane.nsf.gov/a6/A6SrchAwdf.htm COS (Community of Science) http://workbench.cos.com/

Resources

NIH CSR

Training Opportunities in Bioengineering and Bioinformatics at the National Institutes of Health (NIH) & the National Science Foundation (NSF) (NIH: F, Fellowship programs; e.g., F 37 Medical Informatics Fellowship (NLM) K, e.g., K 25 Mentored Quantitative Research Career Development Award Research Career Programs; T, Training Programs, e.g., T 22 Institutional Research Fellowships) http://www.nibib1.nih.gov/training/trainingopps.html NIH Award Data http://grants1.nih.gov/grants/award/award.htm

Resources

NIH CSR National Institute for Biomedical Imaging and Bioengineering (NIBIB): Dick Swaja, Joan Harmon. e.g., Home for BECON. National Institute of General Medical Sciences (NIGMS): Jim Cassatt, Jim Anderson. e.g., Home for BISTI, Center for Bioinformatics and Computational Biology (CBCB), Program for Centers of Excellence in Complex Biomedical Systems Research, NSF-DMS/NIGMS Joint Initiative to Support Research in the Area of Mathematical Biology. National Human Genome Research Institute (NHGRI): Peter Good, Lisa Brooks. e.g., Genome bioinformatics program, Centers of Excellence in G i S i (CEGS)

Resources

NIH CSR National Library of Medicine (NLM): Milt Corn, Carol Bean. e.g,, Integrated Advanced Information Management Systems (IAIMS). National Center for Research Resources (NCRR): Mike Marron. e.g., Biomedical Informatics Research Network (BIRN), BISTI. Neuroscience: NIMH, NINDS, NIDA, NIA, NIAAA: Steve Koslow, Yuan Liu, Mike Huerta, Karen Skinner. e.g., Human Brain Project, Neuroimaging Informatics Technology Initiative (NIfTI).

Resources

NIH CSR

National Cancer Institute (NCI): Larry Clarke, Houston Baker, Peter Covitz. e.g., NCI Center for Bioinformatics (NCICB); the caBIO

• bject modeling effort.

National Institute of Allergy and Infectious Diseases (NIAID): Richard Morris

Resources

Peter Lyster, PhD, CRA Snowbird July 15, 2002. National Institutes of Health (301) 435 1256, lysterp@csr.nih.gov ________________________INFORMATION SOURCES_______________________ CRISP (Computer Retrieval of Information on Scientific Projects) http://crisp.cit.nih.gov/ is a searchable biomedical database of federally-supported proposed research conducted at universities, hospitals, and

• ther research institutions.

NIH Grants Guide http://grants1.nih.gov/grants/guide/ NSF https://www.fastlane.nsf.gov/a6/A6SrchAwdf.htm COS (Community of Science) http://workbench.cos.com/ Training Opportunities in Bioengineering and Bioinformatics at the National Institutes of Health (NIH) & the National Science Foundation (NSF) (NIH: F, Fellowship programs; e.g., F 37 Medical Informatics Fellowship (NLM) K, e.g., K 25 Mentored Quantitative Research Career Development Award Research Career Programs; T, Training Programs, e.g., T 22 Institutional Research Fellowships) http://www.nibib1.nih.gov/training/trainingopps.html NIH Award Data http://grants1.nih.gov/grants/award/award.htm ______________________NIH Institutes and Centers (ICs)________________________ National Institute for Biomedical Imaging and Bioengineering (NIBIB): Dick Swaja, Joan Harmon. e.g., Home for BECON. National Institute of General Medical Sciences (NIGMS): Jim Cassatt, Jim Anderson. e.g., Home for BISTI, Center for Bioinformatics and Computational Biology (CBCB), Program for Centers of Excellence in Complex Biomedical Systems Research, NSF-DMS/NIGMS Joint Initiative to Support Research in the Area of Mathematical Biology. National Human Genome Research Institute (NHGRI): Peter Good, Lisa Brooks. e.g., Genome informatics program, Centers of Excellence in Genomic Science (CEGS). National Library of Medicine (NLM): Milt Corn, Carol Bean. e.g,, Integrated Advanced Information Management Systems (IAIMS). National Center for Research Resources (NCRR): Mike Marron. e.g., Biomedical Informatics Research Network (BIRN), BISTI. Neuroscience: NIMH, NINDS, NIDA, NIA, NIAAA: Steve Koslow, Yuan Liu, Mike Huerta, Karen Skinner. e.g., Human Brain Project, Neuroimaging Informatics Technology Initiative (NIfTI). National Cancer Institute (NCI): Larry Clarke, Houston Baker, Peter Covitz. e.g., NCI Center for Bioinformatics (NCICB); the caBIO object modeling effort. National Institute of Allergy and Infectious Diseases (NIAID): Richard Morris