MutSig http://www.broadinstitute.org/cancer/cga/mutsig Covered - PowerPoint PPT Presentation

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MutSig http://www.broadinstitute.org/cancer/cga/mutsig Covered Bases/Total Possible Mutations for that Gene & Category Score # Observed Background for that mutations in Mutation Rate gene Sum over each that gene & mutation

MutSig
http://www.broadinstitute.org/cancer/cga/mutsig
Covered Bases/Total Possible Mutations for that Gene & Category Score # Observed Background for that mutations in Mutation Rate gene Sum over each that gene & mutation category category
+
Covariate 2 (Z Score) Covariate 1 (Z Score)
Lawrence et al. Nature, Jan 2014.
Do you agree with their chosen inputs? Could a simpler method get the same result? Are there any improvements that could be made?

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