Multiplatform Analysis of 12 Cancer Types Reveals Molecular - - PowerPoint PPT Presentation

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Nov 07, 2022 185 likes •354 views

Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin Hoadley, KA et al. Cell 158(4):929-944 Background Cancers classified based on pathological criteria tissue site of origin

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Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin

Hoadley, KA et al. Cell 158(4):929-944

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Background

Cancers classified based on pathological

criteria – tissue site of origin

TCGA reported genome-wide studies of 10

malignancies

Each single-tissue cancer type can be divided

into 3-4 molecular subtypes

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Motivation

Possible shared molecular alterations across

cancers from different tissues - unclear

Do disease subtypes span multiple tissues of
rigin?
Molecular signatures may give distinct

taxonomy relative to tissue-of-origin-based classification (current method)

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Pan-Cancer-12

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COCA

“Cluster of cluster assignments”
Input : binary vectors representing each platform-

specific cluster group

Each platform influences integrated result with

weight proportional to # of distinct subtypes from consensus clustering

Output : Reclusters samples according to vectors

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Results

1/10 cancer patients classified differently based
n new taxonomy
Guide new therapeutic decisions
Bladder cancers most heterogeneous
“Cell-of-origin” features still dominate molecular