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MOTOR LEARNING IMAGINARY TRAINING NATALIE MRACHACZ-KERSTING USING - - PowerPoint PPT Presentation
MOTOR LEARNING IMAGINARY TRAINING NATALIE MRACHACZ-KERSTING USING - - PowerPoint PPT Presentation
MOTOR LEARNING IMAGINARY TRAINING NATALIE MRACHACZ-KERSTING USING A BRAIN-COMPUTER-INTERFACE FOR MOTOR LEARNING NATALIE MRACHACZ-KERSTING Motor Learning involves neuroplasticity The ability of the nervous system to reorganize neural
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Motor Learning involves neuroplasticity
The ability of the nervous system to reorganize neural pathways based on:
learning new skills recovery from injury artificial induction
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Mechanisms of neuroplasticity
- Persistent changes in synaptic efficacy
proposed by Hebb, 1949; review refer to Sanes & Donoghue, 2000; Cook & Bliss, 2006
- D.O. Hebb and synaptic plasticity:
- Synaptic terminals strengthened by
correlated activity will be retained or sprout new branches.
- Synaptic terminals that are
persistently weakened by non- correlated activity will eventually loose their hold on the post-synaptic cell.
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Paired Associative Stimulation (PAS) in humans
- Effects following PAS are:
- dependent on the timing
between the two stimuli
- specific to the target muscle
- rapidly evolving
- persist upon cessation of the
stimulation period
For a comprehensive review refer to Ziemann et al. (2008) Stefan et al. (2000)
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Paired Associative Stimulation (PAS) in humans
Professor Janne Avela Dr Susanne Kumpulainen
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PAS requires two artificial stimuli: TMS and ES
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The movement related cortical potential as part of PAS
Professor Dario Farina Goettingen, DE Canada Denmark
- Dr. Ning Jiang
- Dr. Kim Dremstrup
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Brain Computer Interfaces (BCI)
Applications:
- Communication
- Gaming
- Rehabilitation
Signal Acquisition:
- Invasive (ECoG, intra-
cortical, etc.)
- Non-invasive (EEG)
Modes:
- Synchronous/cued
- Asynchronous/self-paced
Control Brain Signals:
- ERD/ERS, P300
- MRCP (CNV or
Bereitschaftspotential)
- etc.
[* adapted from Wolpaw et al., 2012]
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The movement related cortical potential as part of PAS
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Real movements Imaginary movements
do Nascimento et al. 2005
The movement related cortical potential
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The movement related cortical potential as part of PAS
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Associativit y
Mrachacz-Kersting et al. (2012) J Physiol
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Associativity and Specificity
Mrachacz-Kersting et al. (2012) J Physiol
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Chronic stroke patients
Mrachacz-Kersting et al. J Neurophysiol (2016)
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Chronic stroke patients – BCIassociative intervention
TMS intensity [%S.O.]
45 50 55 60 65 70
TA p-p MEP amplitude [V]
200 400 600 800 1000 1200 pre-intervetion post-intervention 30 min post-intervention
Mrachacz-Kersting et al. (2016) J Neurophysiol
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Chronic stroke patients - BCIassociative intervention
TMS intensity [%S.O.]
45 50 55 60 65 70
TA p-p MEP amplitude [V]
200 400 600 800 1000 1200 pre-intervetion post-intervention 30 min post-intervention
10 m walk test: Pre: 15.5 s Post 10.5 s Foot Tap Frequ: Pre: 2.31 Hz Post: 3.42 Hz Finger Tap Frequ: Pre: 3.17 Hz Post: 3.18 Hz
Mrachacz-Kersting et al. (2016) J Neurophysiol
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Chronic stroke patients – BCInon-associative intervention
TMS intensity [%S.O.]
40 45 50 55 60 65 70 75
TA p-p MEP amplitude [V]
200 400 600 800 1000 1200 1400 1600
pre-intervetion post-intervention 30 min post-intervention Mrachacz-Kersting et al. (2016) J Neurophysiol
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Chronic stroke patients - BCInon-associative intervention
TMS intensity [%S.O.]
40 45 50 55 60 65 70 75
TA p-p MEP amplitude [V]
200 400 600 800 1000 1200 1400 1600
pre-intervetion post-intervention 30 min post-intervention
10 m walk test: Pre: 8.03 s Post 8.05 s Foot Tap Frequ: Pre: 4.03 Hz Post: 3.8 Hz Finger Tap Frequ: Pre: 0.53 Hz Post: 0.53 Hz
Mrachacz-Kersting et al. (2016) J Neurophysiol
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Acute stroke patients
TMS intensity [%S.O.]
40 45 50 55 60 65 70
TA p-p MEP amplitude [V]
200 400 600 800 1000
Day 1
pre-intervetion post-intervention 30 min post-intervention
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Acute stroke patients
MRCP
Day 6
TMS intensity [%S.O.]
35 40 45 50 55 60 65
TA p-p MEP amplitude [V]
200 400 600 800 1000 pre-intervetion post-intervention 30 min post-intervention
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Acute stroke patients
MRCP
TMS intensity [%S.O.]
35 40 45 50 55 60 65
TA p-p MEP amplitude [V]
200 400 600 800 1000
Day 12
pre-intervetion post-intervention 30 min post-intervention
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Acute stroke patients
TMS intensity [%S.O.]
35 40 45 50 55 60 65
TA p-p MEP amplitude [V]
200 400 600 800 1000
Day 12
pre-intervetion post-intervention 30 min post-intervention
10 m walk test: Pre: 8.47 s Post 5.52 s LE-FM: Pre: 24/34 Post: 33/34
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Acute stroke patients
TMS intensity [%S.O.]
30 35 40 45 50 55 60
TA p-p MEP amplitude [V]
200 400 600 800 1000 pre-intervetion post-intervention 30 min post-intervention
TMS intensity [%S.O.]
84 86 88 90 92 94 96 98 100
TA p-p MEP amplitude [V]
50 100 150 200 250 300 pre-intervetion post-intervention 30 min post-intervention
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HIGH LEVEL ATHLETES
Other applications for the MRCP in motor learning
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Improving athletic performance using real-time neurofeedback
Susan Aliakbaryhosseinabadi Fabiano Landi Xuxian Yin Professor Uwe G. Kersting
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BCI for improving athletic performance using real-time neurofeedback
Susan Aliakbaryhosseinabadi Fabiano Landi Xuxian Yin Uwe G. Kersting
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Special Thanks!
The Chronic study team:
- Vladimir Kostic
- Sasa Radovanovic
- Aleksandra Pavlovic
- Ning Jiang
- Dario Farina
- The patients
The Acute study team:
- Andrew JT Stevenson
- Helle Jørgensen
- Margherita Castronovo
- Kåre E Severinsen
- Jakob Blicher
- Anna C Lundgaard
- Margherita Castronovo
- Fabiano Landi
- Susan
Aliakbaryhosseinabadi
- The patients
The athletic team:
- Uwe G Kersting
- Susan
Aliakbaryhosseinabadi
- Fabiano Landi
- Xu Xian
- The participants
The funders:
- The Obels Family
Foundation
- Spar Nord Fonden
- Lundbeck Fonden
- EU – SEP-210192113