Misconceptions of capture- induced hyperthermia Leith Meyer - - PDF document

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Misconceptions of capture- induced hyperthermia Leith Meyer - - PDF document

Misconceptions of capture- induced hyperthermia Leith Meyer Director Centre for Veterinary Wildlife Management & Associate Professor Senior Honorary Research Fellow Department Paraclinical Sciences Brain Function Research Group -


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Misconceptions of capture- induced hyperthermia

Leith Meyer

Director Centre for Veterinary Wildlife Management & Associate Professor Department Paraclinical Sciences Pharmacology & Toxicology Faculty of Veterinary science Onderstepoort Email address: Leith.meyer@up.ac.za Senior Honorary Research Fellow Brain Function Research Group - Wildlife Conservation Physiology School of Physiology University of the Witwatersrand Braamfontein

Body temperature (°C)

44 42 40 38

2

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Body temperature (°C)

44 42 40 38

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Effects of hyperthermia

 Heat cytotoxicity

 Disrupts metabolic pathways

 Energy supplies  Enzymatic function

 Disrupts membrane structures  Increases cellular metabolism (oxygen +

energy substrates)

 Cell damage and death

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Anthropomorphic delusions

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Anthropomorphic delusions

 The cause of capture-induced hyperthermia

 Heat stroke

6

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Anthropomorphic delusions

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Exercise or Heat Body temperature (°C)

44 42 40 38

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Body temperature (°C)

44 42 40 38

9

Environmental conditions

“Don’t capture animals in the heat of the day because they will get too hot”

10

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0:00 6:00 12:00 18:00 37 38 39 40 41

Time of day Body temperature (oC)

11 12

0:00 6:00 12:00 18:00 37 38 39 40 41

Time of day Body temperature (oC)

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Environmental conditions

0:00 6:00 12:00 18:00 15 20 25 30 35

Time of day Air temeprature (C)

14

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Environmental conditions

0:00 6:00 12:00 18:00 37 38 39 40 41 15 20 25 30 35

Time of day Body temperature (oC) Ambient temeprature (C)

15

Environmental conditions

0:00 6:00 12:00 18:00 10 20 30 40 50 60 Air Black Globe

Time of day Temperature (0C)

16

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Environmental conditions

26 30 34 38 42 1 2 3

A

Dry bulb temperature (oC)

30 34 38 42 46 50 1 2 3

B

Black globe temperature ( oC)

Body temperature change (oC)

17

Activity

18

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Activity

0:00 6:00 12:00 18:00 36 37 38 39 40 10 20 30 40 50

Time of day

Body temperature ( oC) Activity counts

19

11:00 13:00 15:00 17:00 38 39 40 10 20 30 40 50

Time of day

Body temperature ( oC) Activity counts

Activity

20

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Body temperature (°C)

42 40 38 4 8 12 16 20

Time of day

Activity

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Drug effects

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Drug effects

“Opioids are adrenergic and heat is generated by changes in metabolic rate when they are used” Opioids can cause both hyperthermia

  • r hypothermia

Poikilothermia – sedative, tranquilizers, general anaesthetics

23

Body temperature (°C)

42 40 38 4 8 12 16 20

Time of day

No drugs required for hyperthermia

24

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Immobilizing agents

  • Etorphine (M99)
  • Thiafentanil (Thianil)

Tranquilizer/sedative

  • Azaperone
  • Medetomidine

+

25

Drug effects

Etor+Azap Etor+Med Thia+Azap Thia+Med

200 400 600 800

Time to recumbency (s)

26

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Drug effects

60 120 180 240 38 39 40 41 42

Etorphine + azaperone Etorphine + medetomidine Thiafentanil + azaperone Thiafentanil + medetomidine

Time (min) Body temperature (oC)

27

Drug effects

Etor+Azap Etor+Med Thio+Azap Thio+Med

1 2

B ody tem perature change (oC )

28

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Stress

29

37 38 39 40 41 42

Days

Body temperature (oC)

Stress

30

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Stress

25 50 75 100 125 150 1 2 3

Cortisol (nmol l-1) Temperature change (oC)

31

Naïve 2 month 5 month

32

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Naïve 2 month 5 month 25 50 75 100 125 150 175

Cortisol (nm ol l-1)

33

1 2 3 4

A

Body temperature change (oC)

Naïve 2 month 5 month 100 200

B

Cortisol (nmol l-1)

34

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35

Anthropomorphic delusions

 The cause of hyperthermia

 Heat stroke  Stress (stress-induced hyperthermia)

 Capture when it feels good for us

36

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Anthropomorphic delusions

37

Environmental conditions

“All captures should be performed in the cool, early hours of the morning or late afternoon.”

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Environmental conditions

0:00 6:00 12:00 18:00 37 38 39 40 41 15 20 25 30 35

Time of day Body temperature (oC) Ambient temeprature (C)

39

Environmental conditions

0:00 6:00 12:00 18:00 35 36 37 38 39 40 41 42 Summer Winter

Time of day Body temperature (oC)

40

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Environmental conditions

“Don’t capture animals in the heat of the day because they will get too hot”

NB: Post capture

  • Drugs effects
  • Placement of animals

41

26 30 34 38 42 1 2 3

A

Dry bulb temperature (oC)

30 34 38 42 46 50 1 2 3

B

Black globe temperature ( oC)

Body temperature change (oC)

Environmental conditions

“Don’t capture animals when ambient conditions are above 25oC”

42

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Environmental conditions

“Don’t capture animals when ambient conditions are above 25oC” Wet-Bulb Globe Temperature

43

Environmental conditions

“Don’t capture animals when ambient conditions are above 25oC” Wet-Bulb Globe Temperature

44

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Environmental conditions

“Don’t capture animals when ambient conditions are above 25oC” Wet-Bulb Globe Temperature

45

Anthropomorphic delusions

 The cause of hyperthermia

 Heat stroke

 Capture when it feels good for us  Human cooling practices should work well in

animals too.

46

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Anthropomorphic delusions

47

Temperature change:

C

  • n

t r

  • l

i c e I V m i s t 2 8 º C

  • 4
  • 3
  • 2
  • 1

1

In 1 hour

Temperature (ºC)

48

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SLIDE 25

25

49

Anthropomorphic delusions

 The cause of hyperthermia

 Heat stroke

 Capture when it feels good for us  Human cooling practices should work well in

animals too.

50

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Anthropomorphic delusions

 The cause of hyperthermia  Heat stroke  Capture when it feels good for us  Human cooling practices should work well in animals

too.

 Hyperthermia is the root of all evil during capture

51

Consequences of Hyperthermia

Cellular function Oxygen demand (Q10) Tissue damage Organ failure

Death

(capture myopathy)

52

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Pathophysiological effects of capture and efficacy of cooling hyperthermia

c c c

HNC HNC HNC H+C H+C H+C

Chase camp

HNC

Animal Groups

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D a y

  • 1

/ 2 D a y

  • 2

/ 2 D a y 2 D a y 1 6 D a y 3 Rectal Temperature °C

N: 38-39°C

D a y

  • 1

/ 2 D a y

  • 2

/ 2 D a y 2 D a y 1 6 D a y 3 Rectal Temperature °C

cooling N: 38-39°C

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Nv: 0-5 mmol /L cooling N: 0-8 IU/L: cooling

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N: 50-271 IU/I : cooling N ranges: Blesbok: 0,021ng/ml Dogs: 0,02 ng/ml Cats: 0,03-0,16 ng/ml Horses: 0,047 ng/ml cooling

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Effects of Hyperthermia

62

 Maybe capture-induced hyperthermia is not the

root of all evil

 But an indication of the evil that we have

done!!!!

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Conclusion

63

Anthropomorphic delusions

 The cause of hyperthermia  Heat stroke

64

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33

65

Anthropomorphic delusions

 The cause of hyperthermia  Heat stroke  Capture when it feels good for us

66

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Environmental conditions

“Don’t capture animals when ambient conditions are above 25oC” Wet-Bulb Globe Temperature

67

Anthropomorphic delusions

 The cause of hyperthermia  Heat stroke  Capture when it feels good for us  Human cooling practices should work well in animals

too.

68

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35

69

Anthropomorphic delusions

 The cause of hyperthermia  Heat stroke  Capture when it feels good for us  Human cooling practices should work well in animals

too.

70

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Anthropomorphic delusions

 The cause of hyperthermia  Heat stroke  Capture when it feels good for us  Human cooling practices should work well in animals

too.

 Hyperthermia is the root of all evil during capture

71

Effects of Hyperthermia

72

 But an indication of the evil that we have

done!!!!

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Prevention better than cure

Minimise stress

  • Short + slow chases
  • Quick induction times
  • Optimal drug combination
  • Right doses – higher better than lower (side-effects)
  • Minimize loud noises and handle animals with care

(quickly)

  • Ensure animals are place where they don’t gain, but can

lose heat

  • If hyperthermic the damage is done
  • Still cool to prevent further damage

73

Thank you