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Meeting Program Sunday 2:00 pm - 9:00 pm Arrival and Check-in - - PDF document
Meeting Program Sunday 2:00 pm - 9:00 pm Arrival and Check-in - - PDF document
Phosphorylation and G-Protein Mediated Signaling Networks Gordon Research Conference Regulation and Inter-Connectivity of Kinases, Phosphatases and G-Protein Mediated Signaling Pathways in Health and Disease June 3-8, 2018 University of New
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11:45 am - 11:55 am Selected from Poster Abstracts: Ahmed Lawan (Yale University, USA) "Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node that Regulates Obesity-Induced Insulin Resistance" 11:55 am - 12:00 pm Discussion 12:00 pm - 12:10 pm Selected from Poster Abstracts: Nicole Tensmeyer (Brigham Young University, USA) "Chaperone Mediated Assembly of mTOR Complexes" 12:10 pm - 12:15 pm Discussion 12:15 pm - 12:25 pm Selected from Poster Abstracts: Ranga Rajan (University of North Carolina at Chapel Hill, USA) "An Alternative G Protein Signaling Pathway Leads to Autophagy in Saccharomyces cerevisiae" 12:25 pm - 12:30 pm Discussion 12:30 pm Lunch 1:30 pm - 4:00 pm Free Time 3:00 pm - 4:00 pm Power Hour The GRC Power Hour is an optional informal gathering open to all meeting
- participants. It is designed to help address the challenges women face in
science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. Organizer: Rebecca Berdeaux (University of Texas Health Science Center at Houston, USA) 4:00 pm - 6:00 pm Poster Session 6:00 pm Dinner 7:30 pm - 9:30 pm
Neuroscience: Wiring the Neuron by Phosphorylation and G- Proteins
Discussion Leader: Alan Smrcka (University of Michigan, USA) 7:30 pm - 8:00 pm Carmen Dessauer (McGovern Medical School, University of Texas Health Science Center at Houston, USA) "Loss of Opioid and Gi-Dependent Inhibition of Adenylyl Cyclase After Spinal Cord Injury" 8:00 pm - 8:10 pm Discussion 8:10 pm - 8:40 pm Linda Van Aelst (Cold Spring Harbor Laboratory, USA) "Rho Regulator-Mediated Signaling in Inter-Neuron Development and Disease" 8:40 pm - 8:50 pm Discussion 8:50 pm - 9:00 pm Selected from Poster Abstracts: Smita Yadav (University of Washington, USA) "Unmasking Aberrant Phosphorylation Networks in 16p11.2 CNV Associated Autism" 9:00 pm - 9:05 pm Discussion 9:05 pm - 9:15 pm Short Talk Selected from Poster Abstracts 9:15 pm - 9:20 pm Discussion
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9:20 pm - 9:30 pm General Discussion
Tuesday
7:30 am - 8:30 am Breakfast 8:30 am Group Photo 9:00 am - 12:30 pm
Lipids Linking Signaling
Discussion Leader: Kun-Liang Guan (University of California, San Diego, USA) 9:00 am - 9:30 am Jonathan Backer (Albert Einstein College of Medicine, USA) "PI3Kbeta Signaling in Invasion and Metastasis" 9:30 am - 9:40 am Discussion 9:40 am - 9:50 am Selected from Poster Abstracts: Mathew Tantama (Purdue University, USA) "Interrogating Purinergic Signaling: From Extracellular ATP to Intracellular Second Messenger Dynamics" 9:50 am - 9:55 am Discussion 9:55 am - 10:25 am Lloyd Trotman (Cold Spring Harbor Laboratory, USA) "PTEN and the Digital Signaling Hub" 10:25 am - 10:35 am Discussion 10:35 am - 11:05 am Coffee Break 11:05 am - 11:15 am Selected from Poster Abstracts: Alexey Bondar (Augusta University, USA) "Gs Protein Subunits Avoid, but Are Not Excluded from, Clathrin-Coated Pits" 11:15 am - 11:20 am Discussion 11:20 am - 11:30 am Selected from Poster Abstracts: Shelley Hooks (University of Georgia, USA) "RGS10 Regulates COX-2 and TNFalpha Through G Protein Independent Mechanisms" 11:30 am - 11:35 am Discussion 11:35 am - 12:05 pm Aashish Manglik (Stanford University, USA) "Structural Basis of Opioid Receptor Function" 12:05 pm - 12:15 pm Discussion 12:15 pm - 12:25 pm Selected from Poster Abstracts: Yingrong Xu (Pfizer, USA) "Quantitative Analyses of Chemoattractant-Induced Heterotrimeric G Protein Activation Kinetics in Dictyostelium Reveal Important Role for High Affinity Pre- Coupled Receptors" 12:25 pm - 12:30 pm Discussion 12:30 pm Lunch 1:30 pm - 4:00 pm Free Time 4:00 pm - 6:00 pm Poster Session 6:00 pm Dinner
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7:30 pm - 9:30 pm
Cardiovascular System and Vascular Networks
Discussion Leader: Gregory Tall (University of Michigan, USA) 7:30 pm - 8:00 pm Alan Smrcka (University of Michigan, USA) "Subcellular Control of Phospholipase Cepsilon Signaling in Cardiac Function" 8:00 pm - 8:10 pm Discussion 8:10 pm - 8:20 pm Selected from Poster Abstracts: Jaesung Yi (Yale School of Medicine, USA) "PZR Tyrosyl Phosphorylation Is Associated with Hypertrophic Cardiac Gene Expression in Shp2 Associated NSML Model Mice" 8:20 pm - 8:25 pm Discussion 8:25 pm - 8:55 pm Thomas Rich (University of South Alabama, USA) "High Speed Measurement of Agonist-Induced cAMP Signals in Single Cells" 8:55 pm - 9:05 pm Discussion 9:05 pm - 9:15 pm Selected from Poster Abstracts: Nariman Balenga (University of Maryland School of Medicine, USA) "G-Protein-Dependent and -Independent Signaling of Orphan Adhesion GPCR, GPR64" 9:15 pm - 9:20 pm Discussion 9:20 pm - 9:30 pm General Discussion
Wednesday
7:30 am - 8:30 am Breakfast 9:00 am - 12:30 pm
Visualization and Model Systems in Signaling
Discussion Leader: Carmen Dessauer (McGovern Medical School, University
- f Texas Health Science Center at Houston, USA)
9:00 am - 9:30 am Jin Zhang (University of California, San Diego, USA) "Spatial Compartmentalization of Second Messengers and Kinase Complexes in Living Cells" 9:30 am - 9:40 am Discussion 9:40 am - 10:10 am Henrik Dohlman (University of North Carolina at Chapel Hill, USA) "G Protein-Mediated Autophagy in Yeast" 10:10 am - 10:20 am Discussion 10:20 am - 10:30 am Selected from Poster Abstracts: Pascale Charest (University of Arizona, USA) "Quantitative Analyses of Chemoattractant-Induced Heterotrimeric G Protein Activation Kinetics in Dictyostelium Reveal Important Role for High Affinity Pre- Coupled Receptors" 10:30 am - 10:35 am Discussion 10:35 am - 11:05 am Coffee Break 11:05 am - 11:15 am Selected from Poster Abstracts: Chuan-Hsiang Huang (Johns Hopkins University, USA) "Integrating Chemical and Mechanical Signals Through Dynamic Coupling Between Protrusions and ERK Activation"
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11:15 am - 11:20 am Discussion 11:20 am - 11:50 am Roger Sunahara (University of California, San Diego, USA) "The Allostery in G Protein Coupling: From G Proteins to Small Molecules to Cations" 11:50 am - 12:00 pm Discussion 12:00 pm - 12:10 pm Selected from Poster Abstracts: Ajith Karunarathne (The Univerisity of Toledo, USA) "Identity Matters: Ggamma-Type Dictates Efficacy of Gbetagamma Signaling and Cellular Decisions" 12:10 pm - 12:15 pm Discussion 12:15 pm - 12:25 pm Selected from Poster Abstracts: Angeline Lyon (Purdue University, USA) "Conformational Regulation of Phospholipase C Enzymes" 12:25 pm - 12:30 pm Discussion 12:30 pm Lunch 1:30 pm - 4:00 pm Free Time 4:00 pm - 6:00 pm Poster Session 6:00 pm Dinner 7:30 pm - 9:30 pm
Cyclic Nucleotides and GPCR Signaling
Discussion Leader: Henrik Dohlman (University of North Carolina at Chapel Hill, USA) 7:30 pm - 8:00 pm Roshanak Irannejad (University of California, San Francisco, USA) "Toward a Spatiotemporal Logic of Cellular GPCR Signaling by cAMP and PKA" 8:00 pm - 8:10 pm Discussion 8:10 pm - 8:20 pm Selected from Poster Abstracts: Shilpa Choudhury (Georgia Institute of Technology, USA) "Negative Feedback Phosphorylation of G Gamma Subunit Ste18 and the Ste5 Scaffold Synergistically Regulates MAPK Activation in Yeast" 8:20 pm - 8:25 pm Discussion 8:25 pm - 8:55 pm Gregory Tall (University of Michigan, USA) "MAPK Pathway Regulation of Heterotrimeric G Protein Signaling Tone" 8:55 pm - 9:05 pm Discussion 9:05 pm - 9:15 pm Selected from Poster Abstracts: Fadia Kamal (Penn State College of Medicine, USA) "Therapeutic Targeting of GPCR Gbetagamma-GRK2 Signaling in Osteoarthritis" 9:15 pm - 9:20 pm Discussion 9:20 pm - 9:30 pm General Discussion
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Thursday
7:30 am - 8:30 am Breakfast 8:30 am - 9:00 am Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair 9:00 am - 12:30 pm
Nexus of Phosphorylation and G-Protein Signaling
Discussion Leader: Natalie Ahn (University of Colorado Boulder, USA) 9:00 am - 9:30 am Kun-Liang Guan (University of California, San Diego, USA) "Regulation of the Hippo Pathway" 9:30 am - 9:40 am Discussion 9:40 am - 10:10 am Nicholas Tonks (Cold Spring Harbor Laboratory, USA) "New Approaches to Exploiting PTP1B as a Therapeutic Target" 10:10 am - 10:20 am Discussion 10:20 am - 10:30 am Selected from Poster Abstracts: Mary Kay Pflum (Wayne State University, USA) "Chemical Approaches to Identifying Kinase and Phosphatase Substrates" 10:30 am - 10:35 am Discussion 10:35 am - 11:05 am Coffee Break 11:05 am - 11:15 am Selected from Poster Abstracts: Yonghao Yu (University of Texas Southwestern Medical Center, USA) "Non-Cell Autonomous Regulation of mTORC1-Dependent Feedback Mechanisms" 11:15 am - 11:20 am Discussion 11:20 am - 11:50 am Venetia Zachariou (Icahn School of Medicine at Mount Sinai, USA) "Targeting RGSz1 Pathways for the Treatment of Chronic Pain" 11:50 am - 12:00 pm Discussion 12:00 pm - 12:10 pm Selected from Poster Abstracts: Anibal Garza Carbajal (University of Texas Health Science Center at Houston, USA) "Mechanisms Inducing Opioid Resistance After Spinal Cord Injury" 12:10 pm - 12:15 pm Discussion 12:15 pm - 12:25 pm Selected from Poster Abstracts: Zheng Fu (University of Virginia, USA) "ICK Signaling in Ciliopathy" 12:25 pm - 12:30 pm Discussion 12:30 pm Lunch 1:30 pm - 4:00 pm Free Time 4:00 pm - 6:00 pm Poster Session 6:00 pm Dinner
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7:30 pm - 9:30 pm
Cancer Biology and Protein Phosphorylation
Discussion Leader: Jin Zhang (University of California, San Diego, USA) 7:30 pm - 8:00 pm Natalie Ahn (University of Colorado Boulder, USA) "Oncogenic B-Raf Signaling in Melanoma" 8:00 pm - 8:10 pm Discussion 8:10 pm - 8:40 pm
- J. Silvio Gutkind (University of California, San Diego, USA)
"GPCR Signaling and Cancer Immune Therapies" 8:40 pm - 8:50 pm Discussion 8:50 pm - 9:00 pm Selected from Poster Abstracts: Ankita Jaykumar (University of Texas Southwestern Medical Center, USA) "Biological Cross-Talk Between WNK1 and TGF-Beta Signaling Pathway" 9:00 pm - 9:05 pm Discussion 9:05 pm - 9:15 pm Selected from Poster Abstracts: Diwakar Pattabiraman (Norris Cotton Cancer Center, Dartmouth College, USA) "Unraveling a Role for PKA in Mammary Development and Tumor Progression" 9:15 pm - 9:20 pm Discussion 9:20 pm - 9:30 pm General Discussion
Friday
7:30 am - 8:30 am Breakfast 9:00 am Departure
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Poster List
Display your poster at the board # and session indicated below. Posters will be displayed for two days, either Monday- Tuesday or Wednesday-Thursday. Presenters will present their posters on Monday or Wednesday. The second day is to allow for additional viewing and informal discussions. If your name does not appear in the list, display your poster at the next available board in the session which seems most appropriate, or consult with the conference chairs about which session to present in. There is plenty of space available for additional posters. # Session Name Organization Co-Authors Poster Title 1 Mon/Tue Akhmedov, Dmitry The University of Texas Health Science Center at Houston Maria G. Mendoza-Rodriguez, Rebecca Berdeaux Enhancing cAMP/CREB signaling promotes satellite cell proliferation during skeletal muscle regeneration 2 Mon/Tue Alkhatib, Omar King's College London Robson Da Costa, Stuart Bevan and David Andersson Promiscuous G-protein Regulation
- f TRPM3
3 Mon/Tue Bak, Lasse K University of Copenhagen Emil Jakobsen et al. AMP Kinase-mediated selective activation of astrocyte glycolysis via phosphorylation of PFKFB3 as a novel therapeutic approach in Alzheimer's disease 4 Mon/Tue Baldwin, Tanya McGovern Medical School | UTHealth Science Center at Houston Tanya A Baldwin, Yong Li, Cameron S Brand, and Carmen W Dessauer Insights into the regulatory properties of human adenylyl cyclase type 9 5 Mon/Tue Balenga, Nariman University of Maryland School
- f Medicine
Pedram Azimzadeh, John A. Olson, Jr. Regulation of signaling and trafficking of an orphan adhesion GPCR, GPR64 by its N-terminal fragment and tethered peptide 6 Mon/Tue Bondar, Alexey Augusta University Nevin A. Lambert Gs protein subunits avoid, but are not excluded from, clathrin-coated pits 7 Mon/Tue Caengprasath, Natarin Imperial College London Aylin Hanyaloglu, Gary Frost, Edward Tate Post-endocytic trafficking and sorting of FFA2 to very early endosomes 8 Mon/Tue Cerulli, Robert A Tufts University Joshua Kritzer, PhD Phosphotyrosine-mimicking peptides for the inhibition of the STAT3 SH2 domain 9 Mon/Tue Charest, Pascale G University of Arizona AFM T. Islam, Haicen Yue, Margarethakay Scavello, Pearce Haldeman, Wouter-Jan Rappel. Quantitative analyses of chemoattractant-induced heterotrimeric G protein activation kinetics in Dictyostelium reveal important role for high affinity pre- coupled receptors.
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# Session Name Organization Co-Authors Poster Title 10 Mon/Tue Chavez Abiega, Sergei University of Amsterdam Frank J. Bruggeman and Joachim Goedhart Characterization of G-protein signaling by the CaSR using FRET- based biosensors 11 Mon/Tue Chen, Qiuyan Purdue University Qiuyan Chen, Dhabaleswar Patra, Philip Andrews, John Tesmer Structural Basis of the interactions between GPCRs and GPCR kinases 12 Mon/Tue Chen, Songhai S University of Iowa Felix Yang, Maddison Lensing, Yuanchao Ye, Qingwen Qian, Ling Yang WDR26 acts as a hitherto unrecognized PKA-tethering AKAP that regulates hepatic glucose metabolism 13 Mon/Tue Choudhury, Shilpa Georgia Institute
- f Technology
Parastoo Baradaran-Mashinchi, Matthew P. Torres* Negative feedback phosphorylation
- f G gamma subunit Ste18 and the
Ste5 scaffold synergistically regulates MAPK activation in yeast 14 Mon/Tue DeHelian, Daniel J University of Pennsylvania Peisong Ma, Shuchi Gupta, Sara Sampietro, Valerie Tutwiler, Alan Tang, Timothy J. Stalker and Lawrence F. Brass The role of RGS10 in modulating platelet GPCR signaling networks 15 Mon/Tue Doyle, Trevor Purdue Medicinal Chemistry & Molecular Pharmacology Doyle TB, Ejendal KFK, Soto- Velasquez M, Dessauer CW, Hu CD, and Watts VJ Identifying new players and pathways involved in receptor- mediated heterologous sensitization
- f adenylyl cyclase type 5 using
novel BiFC library screening 16 Mon/Tue Fisher, Isaac University of Michigan Meredith Jenkins, Greg Tall, John Burke, and Alan Smrcka Hydrogen-Deuterium exchange reveals distinct activation states of PLCß2 by G-proteins 17 Mon/Tue Fu, Zheng University of Virginia Yixin Tong, Thurl Harris, Thomas Sturgill, David Brautigan ICK Signaling in Ciliopathy 18 Mon/Tue Gao, Yang Cornell University Sekar Ramachandran, Hongli Hu, Georgios Skiniotis, Richard Cerione In Pursuit of a Vision GPCR-G Protein Complex Structure 19 Mon/Tue Garza Carbajal, Anibal University of Texas Health Science Center at Houston Anibal Garza-Carbajal, Alexis Bavencoffe, Elia Lopez, Max A. Odem, Stephen L. Katzen, Edgar
- T. Walters, Carmen W.
Dessauer Mechanisms inducing opioid resistance after spinal cord injury 20 Mon/Tue Hooks, Shelley B University of Georgia to be submitted at a later date RGS10 regulates COX-2 and TNFalpha through G protein independent mechanisms 21 Mon/Tue Huang, Chuan- Hsiang Johns Hopkins University Jr-Ming Yang, Sayak Bhattacharya, Pablo A. Iglesias Integrating chemical and mechanical signals through dynamic coupling between protrusions and ERK activation
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# Session Name Organization Co-Authors Poster Title 22 Mon/Tue Igarashi, Michihiro Niigata unviersity Asami Kawasaki, Shujiro Okuda, Atsushi Tamada, Masayasu Okada Phosphorylation profiles of neuronal growth cones revealed by phosphoproteomics 23 Mon/Tue Iglesias- Bartolome, Ramiro NIH Pilar Pedro, Natalia Salinas- Parra Regulation of epithelial stem cell differentiation and proliferation by heterotrimeric G proteins 24 Mon/Tue Jaykumar, Ankita University of Texas Southwestern Medical Center Ankita B. Jaykumar, Kathy McGlynn, Steve Stippec, Svetlana Earnest, Sachith Gallolu Kankanamalage, Melanie H. Cobb Biological cross-talk between WNK1 and TGF-beta signaling pathway 25 Mon/Tue Kamal, Fadia A Penn State College
- f Medicine
Elijah L Carlson, Eric M Schott, Monaliza El-Quadi, Heather K Le Bleu, John P Ketz, Reyad Elbarbary, Michael J Zuscik, Fadia Kamal Therapeutic targeting of GPCR Gbetagamma-GRK2 signaling in
- steoarthritis
26 Mon/Tue Karunarathne, Ajith The Univerisity of Toledo Kanishka Senarath, John L. Payton, Dinesh Kankanamge, Praneeth Siripurapu, Mithila Tennakoon Identity matters: Ggamma-type dictates efficacy of Gbetagamma signaling and cellular decisions 27 Mon/Tue Kozasa, Tohru Yokohama Univeristy of Pharmacy TBD 28 Mon/Tue Kuznets-Speck, Benjamin D. Case Western Reserve University Tenglong Wang, Joseph Broderick, Michael Hinczewski The Price is Right: Fuel Economy, Fidelity and Speed in Cellular Signaling 29 Mon/Tue Lawan, Ahmed Yale University Ahmed Lawan, Kisuk Min, Lei Zhang, Alberto Canfran-Duque, Michael J. Jurczak, Joao Paulo
- G. Camporez, Yaohui Nie,
Timothy P. Gavin, Gerald I. Shulman, Carlos Fernandez- Hernando, and Anton M. Bennett Skeletal muscle-specific deletion of MKP-1 reveals a p38 MAPK/JNK/Akt signaling node that regulates
- besity-induced insulin resistance
30 Mon/Tue Molliver, Derek C University of New England Diana J. Goode, Ramaz Geguchadze Characterization of novel substrate proteins for Epac-dependent PKC signaling activated by Gs-coupled receptors 1 Wed/Thu Lippert, Lisa G University of Minnesota Sivaraj Sivaramakrishnan Allosteric Effects of ATP-Competitive Inhibitors on Regulatory Interactions in Multi-Domain Kinases 2 Wed/Thu Liu, Wen Hong Kong University of Science and Technology Anthony S.L. Chan, Ka Ming Wong, Yung H. Wong Non-dissociable Gß-Ga Fusion Proteins Reveal Different Mechanisms of G protein Activation
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# Session Name Organization Co-Authors Poster Title 3 Wed/Thu Lopez, Elia R University of Texas Health Science Center at Houston Odem MA, Bavencoffe A, Dessauer CW, Walters ET Serotonin Potentiates Ongoing Activity in Primary Sensory Neurons 4 Wed/Thu Lucato, Christina M Monash University Michelle L Halls; Christina A Mitchell; James C Whisstock; and Andrew M Ellisdon An integrated structural characterization of P-Rex1 activity in cancer cell signaling 5 Wed/Thu Lyon, Angeline M Purdue University Elisabeth E. Garland-Kuntz, Frank S. Vago, Michelle Van Camp, Monita Sieng, Clairissa Corpstein, Arryn Blaine, and Wen Jiang Conformational Regulation of Phospholipase C Enzymes 6 Wed/Thu MADUKWE, JERRY UNIVERSITY OF MICHIGAN Elizabeth Garland-Kuntz, Angeline Lyon, Alan Smrcka G protein ßy subunits directly interact with and activate phospholipase Ce 7 Wed/Thu Mertz, Christoffer University of Copenhagen Dennis Özcelik, Dermot M. F. Cooper, Kristian Strømgaard and Lasse K. Bak Development of peptides capable of breaking the AC8-AKAP79 interaction as a novel approach to manipulate calcium-driven cAMP signaling 8 Wed/Thu Min, Kisuk Yale University Yan Huang, Frank Giordano, and Anton Bennett Role of MAP Kinase phosphatase-5 (MKP-5) in cardiac function 9 Wed/Thu Nassiri Toosi, Zahra Georgia Institute
- f Technology
Matthew P Torres A dual phosphorylation switch in the intrinsically disordered G? N- terminus tunes MAPK activation in yeast 10 Wed/Thu Pattabiraman, Diwakar R Dartmouth College/Norris Cotton Cancer Center Gadisti Aisha Mohamed, Nevena B. Ognjenovic Unraveling a role for PKA in mammary development and tumor progression 11 Wed/Thu Pflum, Mary Kay H Wayne State University Chemical Approaches to Identifying Kinase and Phosphatase Substrates 12 Wed/Thu Poon, Carole Peter MacCallum Cancer Centre Weijie Liu, Yanjun Song, Marta Gomez, Yavuz Kulaberoglu, Xiaomeng Zhang, Wenjian Xu, Alexey Veraksa, Alexander Hergovich, Amin Ghabrial and Kieran F. Harvey A Hippo-like signalling pathway controls tracheal morphogenesis in Drosophila melanogaster 13 Wed/Thu Rada, Cara UCSD Hilda Mejia-Pena, Isabel Canto, and JoAnn Trejo PAR1 and p38 MAPK Regulation of Endothelial Pro-Inflammatory Responses 14 Wed/Thu Rajan, Ranga University of North Carolina at Chapel Hill Claire Gordy, Lauren Askew, Samantha Bevill, Jillian Hurst, Joshua Kelley, Joshua Sheetz, Kimiko Suzuki, Everett Young, Henrik Dohlman An alternative G protein signaling pathway leads to autophagy in Saccharomyces cerevisiae
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# Session Name Organization Co-Authors Poster Title 15 Wed/Thu Ray, Upasana Indian Institute of Chemical Biology, CSIR A metabolite-induced metabolic rewiring of ovarian cancer cells through GPCR signaling 16 Wed/Thu Reggi, Erica University of Lausanne Halima Osman, Dario Diviani Role of AKAP2 in prostate cancer 17 Wed/Thu Rich, Thomas C University of South Alabama J.R. Griswold, J. Deal, N. Annamdevula, S. Mayes, and S.J. Leavelsy High speed measurement of agonist-induced cAMP signals in single cells 18 Wed/Thu Singh, Sukrit Washington University in St. Louis Xianqiang Sun, Kendall J. Blumer, Gregory R. Bowman Simulation of spontaneous G protein activation reveals a new intermediate driving GDP unbinding 19 Wed/Thu Tantama, Mathew Purdue University Jason Conley, Ph.D., Stephen Valentino, Daniel Cholger Interrogating Purinergic Signaling: From Extracellular ATP to Intracellular Second Messenger Dynamics 20 Wed/Thu Tensmeyer, Nicole C Brigham Young University Jorge Cuellar, Nicole C. Tensmeyer, Takuma Aoba, W. Grant Ludlam, Madhura Dhavale, Teresa Bueno, Rebecca Plimpton, Aman Makaju, Sarah Franklin, Barry
- M. Willardson, Jose M.
Valpuesta Chaperone Mediated Assembly of mTOR Complexes 21 Wed/Thu Tesmer, John J Purdue University John J. G. Tesmer, Jennifer N. Cash, Sumit J. Bandekar, Prateek V. Sharma, Brittany A. Tang, Ena S. Tully, Brenna L. Barton, Nadia Arang, J. Silvio Gutkind Structure and Function of GPCR- Linked Rho Guanine Nucleotide Exchange Factors 22 Wed/Thu Todd, Tyson Washington University in St. Louis Michael D. Onken, Carol M. Makepeace, Kevin M. Kaltenbronn, Stanley M. Kanai, Tyson D. Todd, Shiqi Wang, Thomas J. Broekelmann, Prabakar Kumar Rao, John A. Cooper, and Kendall J. Blumer Targeting nucleotide exchange to inhibit constitutively active G protein alpha-subunits in cancer 23 Wed/Thu Vincent, Pierre UPMC Cédric Yapo; Anu G. Nair; Jeanette Hellgren Kotaleski; Liliana R. V. Castro Dopamine D1 receptors produce a switch-like PKA responses in the nucleus of striatal neurons 24 Wed/Thu Xu, Yingrong Pfizer Jill Chrencik, Kimberly F. Fennell, Billy Breton, Arturo Mancini, Xiayang Qiu and Graham M. West Deciphering phosphorylation codes that regulate MOR signaling 25 Wed/Thu Yadav, Smita University of Washington Unmasking aberrant phosphorylation networks in 16p11.2 CNV associated autism
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# Session Name Organization Co-Authors Poster Title 26 Wed/Thu Yerramilli, Venkata Siddartha K Worcester Polytechnic Institute Suzanne Scarlata, Arne Gericke CHARACTERIZATION OF IQGAP1 BINDING TO PHOSPHOINOSITIDES AND PIP KINASES 27 Wed/Thu Yi, Jaesung Yale School of Medicine / Department of Pharmacology Yan Huang, Frank J. Giordano and Anton M. Bennett PZR tyrosyl phosphorylation is associated with hypertrophic cardiac gene expression in Shp2 associated NSML model mice 28 Wed/Thu Yu, Yonghao University of Texas Southwestern Medical Center Xiaozheng Zhao, Guangjun Nie and Yonghao Yu Non-cell Autonomous Regulation of mTORC1-dependent Feedback Mechanisms 29 Wed/Thu Yu, Wenxi Department of Pharmacology, University of Michigan Makaia Papasergi-Scott, Hannah Stoveken, Maiya Yu, Lauren MacConnachie, Dorothy Wong, Asim Beg, and Gregory
- G. Tall
RIC-8A C-TERMINUS PHOSPHOSITES REGULATE G PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE EXCHANGE ACTIVITIES
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Conference Registration List Phosphorylation and G-Protein Mediated Signaling Networks
Regulation and Inter-Connectivity of Kinases, Phosphatases and G-Protein Mediated Signaling Pathways in Health and Disease Gordon Research Conference June 3-8, 2018 University of New England, Biddeford, ME Chair: Anton Bennett Vice Chair: Rebecca Berdeaux Important Note: The information in this Registration List is provided as a convenience to enable attendees to collaborate and keep in touch. In accordance with GRC policy, this information should not be shared with non- registered attendees. Please respect the privacy of the other meeting attendees by not compiling email lists for the purpose of sending unsolicited emails, or by sharing their personal information without approval. Thank you. Ahn, Natalie G University of Colorado Boulder Department of Chemistry and Biochemistry Campus Box 0596 Boulder, CO 80309-0596 USA Phone: 303-492-4799 Fax: 303-492-2439 Email: natalie.ahn@colorado.edu Participation: Speaker Akhmedov, Dmitry University of Texas Health Science Center at Houston Department of Integrative Biology and Pharmacology McGovern Medical School, 6431 Fannin Street Houston, TX 77030 USA Phone: 713-500-5697 Fax: Email: dmitry.akhmedov@uth.tmc.edu Participation: Poster Presenter Alkhatib, Omar King's College London Wolfson Centre for Age-Related Diseases Guy's Campus King's College London London SE11UL United Kingdom Phone: +447771261202 Fax: Email:
- mar.alkhatib@kcl.ac.uk
Participation: Poster Presenter Backer, Jonathan M Albert Einstein College of Medicine 1300 Morris Park Avenue Bronx, NY 10461 USA Phone: 718-430-2153 Fax: Email: jonathan.backer@einstein.yu.edu Participation: Speaker Bak, Lasse K University of Copenhagen
- Dept. of Drug Design and Pharmacology
2 Universitetsparken Copenhagen 2100 Denmark Phone: +4535336304 Fax: Email: laba@sund.ku.dk Participation: Speaker
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Baldwin, Tanya McGovern Medical School, University of Texas Health Science Center at Houston Integrative Biology & Pharmacology 6431 Fannin St MSB 4.002 Houston, TX 77030 USA Phone: 713-500-6330 Fax: Email: tanya.baldwin@uth.tmc.edu Participation: Poster Presenter Balenga, Nariman University of Maryland School of Medicine 655 W. Baltimore St Room 10-027 Baltimore, MD 21201 USA Phone: 4107063261 Fax: Email: nbalenga@som.umaryland.edu Participation: Speaker Bennett, Anton Yale University Department of Pharmacology PO Box 208066 333 Cedar Street, B226D New Haven, CT 06520-8066 USA Phone: 203-737-2441 Fax: 203-737-2738 Email: anton.bennett@yale.edu Participation: Chair Berdeaux, Rebecca University of Texas Health Science Center at Houston Integrative Biology and Pharmacology McGovern Medical School 6431 Fannin St., MSE R366 Houston, TX 77030 USA Phone: 713-500-5653 Fax: Email: rebecca.berdeaux@uth.tmc.edu Participation: Vice Chair Bondar, Alexey Augusta University Department of Pharmacology and Toxicology 1460 Laney Walker Blvd (Sanders Building) CB3517 Augusta, GA 30912 USA Phone: 7067216336 Fax: Email: abondar@augusta.edu Participation: Speaker Caengprasath, Natarin Imperial College London Department of Medicine, Section of Investigative Medicine Floor 6 Commonwealth Building Imperial College Du Cane Road London W12 0NN United Kingdom Phone: 44-756-815-5105 Fax: Email: natarin.caengprasath12@imperial.ac.uk Participation: Poster Presenter Cerulli, Robert A Tufts University Department of Chemistry 62 Talbot Avenue Medford, MA 02155 USA Phone: 7813073902 Fax: Email: robert.cerulli@tufts.edu Participation: Poster Presenter
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Charest, Pascale G University of Arizona Department of Chemistry and Biochemistry 1041 E. Lowell Street Bio Sciences West, room 345 Tucson, AZ 85721-0088 USA Phone: 520-626-2916 Fax: Email: pcharest@email.arizona.edu Participation: Speaker Chavez Abiega, Sergei University of Amsterdam Science Park 904 Amsterdam 1098 XH The Netherlands Phone: +31616846192 Fax: Email: s.chavezabiega@vu.nl Participation: Poster Presenter Chen, Qiuyan Purdue University 240 S. Martin Jischke Drive
- Rm. 367, Tesmer lab
West Lafayette, IN 47907-2054 USA Phone: 6157793239 Fax: Email: chen2747@purdue.edu Participation: Poster Presenter Chen, Songhai S University of Iowa Department of Pharmacology 2-250 BSB 51 Newton Road Iowa City, IA 52242 USA Phone: 319-384-4562 Fax: Email: songhai-chen@uiowa.edu Participation: Poster Presenter Choudhury, Shilpa Georgia Institute of Technology 950 Atlantic Drive EBB1 Building 4223 Atlanta, GA 30332 USA Phone: 213-572-8324 Fax: Email: schoudhury31@gatech.edu Participation: Speaker Cobb, Melanie H University of Texas Southwestern Medical Center Department of Pharmacology 5323 Harry Hines Boulevard Dallas, TX 75390-9041 USA Phone: 214-645-6122 Fax: 214-645-6124 Email: melanie.cobb@utsouthwestern.edu Participation: Speaker DeHelian, Daniel J University of Pennsylvania Department of Medicine; Division of Hematology/Oncology Biomedical Research Building II/III RM 821 421 Curie Blvd Philadelphia, PA 19104 USA Phone: 2155733541 Fax: Email: dehelian@pennmedicine.upenn.edu Participation: Poster Presenter
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Dessauer, Carmen W McGovern Medical School, University of Texas Health Science Center at Houston Department of Integrative Biology and Pharmacology 6431 Fannin St. Houston, TX 77030 USA Phone: 7135006308 Fax: 7135007444 Email: carmen.w.dessauer@uth.tmc.edu Participation: Speaker Dohlman, Henrik G University of North Carolina at Chapel Hill Pharmacology 4016 Genetic Medicine Building Chapel Hill, NC 27599 USA Phone: 919-843-6894 Fax: Email: henrik_dohlman@med.unc.edu Participation: Speaker Doyle, Trevor Purdue Medicinal Chemistry & Molecular Pharmacology Purdue University
- Dept. of Medicinal Chemistry and Molecular Pharmacology
575 Stadium Mall Drive Lafayette, IN 47906 USA Phone: 3039317700 Fax: Email: doyle34@purdue.edu Participation: Poster Presenter Fisher, Isaac University of Michigan 1150 W Med Center Dr. MSRBII Room 5558 Ann Arbor, MI 48109 USA Phone: 5857345743 Fax: Email: ifisher@med.umich.edu Participation: Poster Presenter Fu, Zheng University of Virginia Department of Pharmacology Pinn Hall 5217, PO Box 800735 1340 Jefferson Park Avenue Charlottesville, VA 22908 USA Phone: 434-982-3204 Fax: Email: zf6n@virginia.edu Participation: Speaker Gao, Yang Cornell University Department of Chemistry and Chemical Biology 302 Baker Lab Cornell University Ithaca, NY 14853 USA Phone: 6072794585 Fax: Email: yg279@cornell.edu Participation: Poster Presenter Garza Carbajal, Anibal University of Texas Health Science Center at Houston Department of Integrative Biology and Pharmacology McGovern Medicical School Houston, TX 77030 USA Phone: 18325188519 Fax: Email: anibal.garzacarbajal@uth.tmc.edu Participation: Speaker
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Guan, Kun-Liang University of California, San Diego Scrm, 2880 Torrey Pines Scenic DR. LA Jolla, CA 92037 USA Phone: 858-822-7945 Fax: Email: kuguan@ucsd.edu Participation: Speaker Gutkind, J. Silvio University of California, San Diego Moores Cancer Center 3855 Health Sciences Drive #0803, Room 2344 La Jolla, CA 92093 USA Phone: 2404233514 Fax: Email: sgutkind@ucsd.edu Participation: Speaker Gutknecht, Eric Idorsia Pharmaceuticals Hegenheimermattweg 91 Allschwil 4123 Switzerland Phone: 0588440134 Fax: Email: eric.gutknecht@idorsia.com Participation: Attendee Hooks, Shelley B University of Georgia 338PS 230 West Green Street Athens, GA 30602 USA Phone: 706-542-2189 Fax: 706-542-2189 Email: shooks@uga.edu Participation: Speaker Huang, Chuan-Hsiang Johns Hopkins University Department of Pathology 725 N. Wolfe St., 103 Hunterian Baltimore, MD 21205 USA Phone: 410-614-5938 Fax: Email: chuang29@jhmi.edu Participation: Speaker Igarashi, Michihiro Niigata unviersity
- Dept. of Neurochemistry and Molecular Cell biology
Niigata Univ Grad Sch of Medical and Dental Sciences 1-757 Asahimachi, Chuo-ku Niigata 951-8510 Japan Phone: +81252272083 Fax: Email: tarokaja@med.niigata-u.ac.jp Participation: Speaker Iglesias-Bartolome, Ramiro NIH 9000 Rockville Pike BLDG 37 ROOM 2050 Bethesda, MD 20892 USA Phone: 301-204-2600 Fax: Email: ramiro.iglesias-bartolome@nih.gov Participation: Poster Presenter Irannejad, Roshanak University of California, San Francisco 555 Mission Bay Blvd S Room 352H San Francisco, CA 94158 USA Phone: 4844109965 Fax: Email: roshanak.irannejad@ucsf.edu Participation: Speaker
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Irnaten, Mustapha Mater Hospital, University College Dublin Catherine McAuley Centre Department of Ophthalmology 21 Nelson Street Dublin D07 F851 Ireland Phone: +35314445659 Fax: Email: mirnaten2014@gmail.com Participation: Attendee Jaykumar, Ankita University of Texas Southwestern Medical Center 5940 Forest Park road Apt-3085 Dallas, TX 75235 USA Phone: 5863823486 Fax: Email: ankita.jaykumar@utsouthwestern.edu Participation: Speaker Kamal, Fadia A Penn State College of Medicine 500 University Dr Hershey, PA 17033 USA Phone: 7175314808 Fax: Email: fkamal@pennstatehealth.psu.edu Participation: Speaker Karunarathne, Ajith The Univerisity of Toledo 2801 West Bancroft Street Department of Chemistry and Biochemistry Mail Stop: 602 Toledo, OH 43606 USA Phone: 419-530-7880 Fax: 419-530-4033 Email: ajith.karunarathne@utoledo.edu Participation: Speaker Kozasa, Tohru Yokohama Univeristy of Pharmacy Department of Biochemistry, Center for Drug Development 601 Matano-machi, Totsuka-ku Yokohama, Kanagawa 245-0066 Japan Phone: 81-45-859-1300 Fax: 81-3-5452-5230 Email: kozasa@lsbm.org Participation: Poster Presenter Kuliawat, Regina M Albert Einstein College of Medicine 1300 Morris Park Avenue Chanin 513 Bronx, NY 10461 USA Phone: 718-430-8686 Fax: Email: regina.kuliawat@einstein.yu.edu Participation: Attendee Lawan, Ahmed Yale University Department of Pharmacology 333 Cedar Street New Haven, CT 06520 USA Phone: (203) 435-1346 Fax: Email: ahmed.lawan@yale.edu Participation: Speaker Lippert, Lisa G University of Minnesota 420 Washington Ave. SE 4-184 MCB Minneapolis, MN 55455 USA Phone: 2152009970 Fax: Email: llippert@umn.edu Participation: Poster Presenter
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Liu, Wen Hong Kong University of Science and Technology Room 6141 , Acdemic Building, Division of Life science HKUST Hong Kong 999077 Hong Kong SAR China Phone: 66558756 Fax: Email: jeff_storm@outlook.com Participation: Poster Presenter Lopez, Elia R University of Texas Health Science Center at Houston Department of Integrative Biology and Pharmacology Houston, TX 77030 USA Phone: 7138989384 Fax: Email: elia.lopez@uth.tmc.edu Participation: Poster Presenter Lucato, Christina M Monash University Department of Biochemistry & Molecular Biology Building 77, Monash University Wellington Rd Clayton, Victoria 3800 Australia Phone: +61402031905 Fax: Email: christina.lucato@monash.edu Participation: Poster Presenter Lyon, Angeline M Purdue University Department of Chemistry 560 Oval Drive West Lafayette, IN 47907 USA Phone: 765-494-5291 Fax: Email: lyonam@purdue.edu Participation: Speaker Mertz, Christoffer University of Copenhagen Universitetsparken 2, Department of Drug Design and Pharmacology København Ø 2100 Denmark Phone: 21855852 Fax: Email: wtr527@alumni.ku.dk Participation: Poster Presenter Min, Kisuk Yale University 333 Cedar Street New Haven, CT 06520 USA Phone: 203-785-4395 Fax: Email: kisuk.min@yale.edu Participation: Poster Presenter Molliver, Derek C University of New England Dept Biomedical Sciences Biddeford, ME 04005-9599 USA Phone: 207-602-2221 Fax: Email: dmolliver@une.edu Participation: Poster Presenter Nassiri Toosi, Zahra Georgia Institute of Technology 950 Atlantic Dr NW, Engineered Biosystems Building, School of Biological Sciences Atlanta, GA 30332 USA Phone: 6787047773 Fax: Email: z.nassiritoosi@gatech.edu Participation: Poster Presenter
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Pattabiraman, Diwakar R Norris Cotton Cancer Center, Dartmouth College 1 Medical Center Drive Lebanon, NH 03756 USA Phone: 6179491187 Fax: Email: raman@dartmouth.edu Participation: Speaker Pflum, Mary Kay H Wayne State University Department of Chemistry 5101 Cass Avenue Detroit, MI 48202 USA Phone: 313-577-1515 Fax: Email: pflum@wayne.edu Participation: Speaker Pierre, Nicolas Cisbio US Inc 135 South Road Bedford, MA 01730 USA Phone: 7812906897 Fax: Email: npierre@cisbio.us Participation: Attendee Poon, Carole Peter MacCallum Cancer Centre Cancer Research Division 305 Grattan Street Melbourne 3000 Australia Phone: 61385596456 Fax: Email: carole.poon@petermac.org Participation: Poster Presenter Rada, Cara UCSD 9500 Gillman Dr BSB 3046 MC 0636 La Jolla, CA 92093 USA Phone: 8582460343 Fax: Email: crada@ucsd.edu Participation: Poster Presenter Rajan, Ranga University of North Carolina at Chapel Hill Department of Pharmacology 120 Mason Farm Road 4100F Genetic Medicine Building Chapel Hill, NC 27599 USA Phone: 6083202911 Fax: Email: ranga@email.unc.edu Participation: Speaker Ramachandran, Sekar Cornell University Department of Chemistry and Chemical Biology 316 Baker Labs Ithaca, NY 14853 USA Phone: 607-254-6767 Fax: 607-255-1189 Email: sr77@cornell.edu Participation: Attendee Reggi, Erica University of Lausanne Department of pharmacology and toxicology Rue du Bugnon 27 Lausanne 1011 Switzerland Phone: +41216925465 Fax: Email: erica.reggi@unil.ch Participation: Poster Presenter
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Rich, Thomas C University of South Alabama Department of Pharmacology College of Medicine 5851 USA Drive N, MSB 3370 Mobile, AL 36688 USA Phone: 251-460-6039 Fax: Email: trich@southalabama.edu Participation: Speaker Selden, Chuck MIST Study Section, Center for Scientific Review, National Institutes of Health Rockledge 2, rm 5158 6701 Rockledge Drive Bethesda, MD 20892 USA Phone: 301-451-3388 Fax: Email: seldenc@nih.gov Participation: Attendee Shillingford, Shanelle R Yale University, GSAS 120 Dwight Street Apt 203 Apt 203 New Haven, CT 06511 USA Phone: 3472737543 Fax: Email: shanelle.shillingford@yale.edu Participation: Attendee Singh, Sukrit Washington University in St. Louis Bowman lab, Department of Biochemistry and Molecular Biophysics Biochemistry, CB8231 4523 Clayton Ave. St Louis, MO 63110 USA Phone: 3146855659 Fax: Email: sukritsingh92@gmail.com Participation: Poster Presenter Smrcka, Alan University of Michigan Department of Pharmacology 1150 W. Medical Center Drive MSRB2 Room 5560C Ann Arbor, MI 48109 USA Phone: 734-615-4945 Fax: Email: avsmrcka@med.umich.edu Participation: Speaker Spite, Matthew Harvard Medical School / Brigham and Women's Hospital 60 Fenwood Rd., Room 3016K Building for Transformative Medicine Boston, MA 02115 USA Phone: 617-525-5133 Fax: Email: mspite@bwh.harvard.edu Participation: Speaker Sunahara, Roger K University of California, San Diego 4062 Biomedical Sciences Building 9500 Gilman Drive La Jolla, CA 92093 USA Phone: 8582461967 Fax: Email: rsunahara@ucsd.edu Participation: Speaker
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Tall, Gregory G University of Michigan 1150 West Medical Center Drive Department of Pharmacology Ann Arbor, MI 48109 USA Phone: 734-763-7154 Fax: Email: gregtall@med.umich.edu Participation: Speaker Tantama, Mathew Purdue University Department of Chemistry 560 Oval Drive Box 68 WTHR 331B West Lafayette, IN 47907 USA Phone: 765-494-5312 Fax: Email: mtantama@purdue.edu Participation: Speaker Tensmeyer, Nicole C Brigham Young University Department of Chemistry and Biochemistry Provo, UT 84602 USA Phone: 8014222278 Fax: Email: nicole.tensmeyer@gmail.com Participation: Speaker Tesmer, John J Purdue University 240 S. Martin Jischke Drive, Room 329 West Lafayette, IN 47907-2054 USA Phone: 7654941807 Fax: Email: jtesmer@purdue.edu Participation: Poster Presenter Todd, Tyson Washington University in St. Louis Department of Cell Biology and Physiology 660 South Euclid Avenue
- St. Louis, MO 63110 USA
Phone: 3143621662 Fax: Email: tyson.d.todd@wustl.edu Participation: Poster Presenter Tonks, Nicholas K Cold Spring Harbor Lab 1 Bungtown Road Cold Spring Harbor, NY 11724 USA Phone: 516-367-8846 Fax: Email: tonks@cshl.edu Participation: Attendee Trotman, Lloyd Cold Spring Harbor Laboratory 1 Bungtown Road Cold Spring Harbor, NY 11724 USA Phone: 516-367-5054 Fax: Email: trotman@cshl.edu Participation: Speaker Tunaru, Sorin Max Planck Institute for Heart and Lung Research
- Dept. of Pharmacology
Ludwigstrasse 43 Bad Nauheim 61231 Germany Phone: +49(0)6032 7051210 Fax: Email: sorin.tunaru@mpi-bn.mpg.de Participation: Speaker
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Van Aelst, Linda Cold Spring Harbor Laboratory 1 Bungtown Rd Cold Spring Harbor, NY 11724 USA Phone: 516-367-6829 Fax: 516-367-8815 Email: vanaelst@cshl.edu Participation: Speaker Vincent, Pierre UPMC UMR8256 "Biological Adaptation and Ageing" 4 place Jussieu Paris 75005 France Phone: 33-144-272-588 Fax: Email: pierre.vincent@upmc.fr Participation: Poster Presenter Willardson, Barry M Brigham Young University Department of Chemistry and Biochemistry C-100 BNSN Provo, UT 84602 USA Phone: 801-422-2785 Fax: Email: bmwillardson@chem.byu.edu Participation: Attendee Xu, Yingrong Pfizer 445 Eastern Point Rd. 8220-326L Groton, CT 06340 USA Phone: 9196388660 Fax: Email: xyret900913@gmail.com Participation: Speaker Yadav, Smita University of Washington Department of Pharmacology 1959 NE Pacific Street Health Sciences Building, Room F404 Seattle, WA 98195 USA Phone: 412-759-8634 Fax: Email: smita.yadav@gmail.com Participation: Speaker Yerramilli, Venkata Siddartha K Worcester Polytechnic Institute Department of Chemistry and Biochemistry 60 Prescott Street Room 0110, Gateway Park Worcester, MA 01605 USA Phone: 6312295896 Fax: Email: vkyerramilli@wpi.edu Participation: Poster Presenter Yi, Jaesung Yale School of Medicine Department of Pharmacology 333 Cedar St. SHM B-225 New Haven, CT 06520 USA Phone: 2037854395 Fax: Email: jae-sung.yi@yale.edu Participation: Speaker Yu, Wenxi Department of Pharmacology, University of Michigan Department of Pharmacology Ann Arbor, MI 48109 USA Phone: 3135108751 Fax: Email: wenxiyu@med.umich.edu Participation: Poster Presenter
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