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Liver transplant meeting 19th September 2017 Dr Tu Vinh Luong - PowerPoint PPT Presentation

Feb 03, 2023 •126 likes •377 views

Liver transplant meeting 19th September 2017 Dr Tu Vinh Luong Royal Free Hospital Royal Free Hospital - Case A Female 41 years Liver transplant in Feb 2017 for PBC. Stable at clinical follow-ups until July 2017 when a liver biopsy

  1. Liver transplant meeting 19th September 2017 Dr Tu Vinh Luong Royal Free Hospital

  2. Royal Free Hospital - Case A • Female 41 years • Liver transplant in Feb 2017 for PBC. • Stable at clinical follow-ups until July 2017 when a liver biopsy was performed for worsening graft function (ALT 210, AST 161, bilitubin 41). • ? rejection.

  3. Royal Free Hospital - Case A

  4. Royal Free Hospital - Case A

  5. Royal Free Hospital - Case A HE DPAS

  6. Royal Free Hospital - Case A

  7. Royal Free Hospital - Case A

  8. Royal Free Hospital - Case B • Female 36 years • Patient underwent transplant on 28.03.17 for PSC, receiving a split graft. • She developed graft dysfunction due to hepatic artery thrombosis and required supraurgent re-transplantation on 06.04.17. • The time zero liver biopsy at the 1st transplantation was negative for C4d. • The slides submitted are from the second transplantation (split graft) and post transplant liver biopsy performed on day 5 after the second transplant. • Split graft/second explant - slides 381810 and 381811. • Day 5 - slides 381812 and 381813.

  9. Split graft/second explant slide 381810

  10. Split graft/second explant slide 381810

  11. Split graft/second explant slide 381810

  12. Split graft/second explant slide 381810

  13. Split graft/second explant slide 381810

  14. Split graft/second explant slide 381810

  15. Split graft/second explant slide 381811 – C4d

  16. Split graft/second explant slide 381811 – C4d

  17. Split graft/second explant slide 381811 – C4d

  18. Further clinical information • Positivity for donor specific antibodies • Treatment with cycles of plasma exchange

  19. Day 5 - slides 381812

  20. Day 5 - slides 381812

  21. Day 5 - slides 381812

  22. Day 5 - slides 381813 – C4d

  23. Day 5 - slides 381813 – C4d

  24. Day 5 - slides 381813 – C4d

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