leveraging the natural strengths of humanity and our

KIADIS PHARMA | COMPANY PRESENTATION | NOVEMBER 2019 EURONEXT: KDS Leveraging the natural strengths of humanity and our collective immune systems to source the best cells for life Cell therapy to treat cancer, combining innate and adaptive

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  1. KIADIS PHARMA | COMPANY PRESENTATION | NOVEMBER 2019 EURONEXT: KDS Leveraging the natural strengths of humanity and our collective immune systems to source the best cells for life Cell therapy to treat cancer, combining innate and adaptive immune system

  2. Disclaimer These slides and the accompanying oral presentation contain forward-looking statements and information. Forward-looking statements are subject to known and unknown risks, uncertainties, and other factors that may cause our or our industry’s actual results, levels or activity, perf ormance or achievements to be materially different from those anticipated by such statements. The use of words such as “may”, “might”, “will”, “should”, “could”, “exp ect ”, “plan”, “anticipate”, “believe”, “estimate”, “project”, “intend”, “future”, “potential” or “continue”, and other similar expressions are intended to identify forward looking statements. For example, all statements we make regarding (i) the initiation, timing, cost, progress and results of our preclinical and clinical studies and our research and development programs, (ii) our ability to advance product candidates into, and successfully complete, clinical studies, (iii) the timing or likelihood of regulatory filings and approvals, (iv) our ability to develop, manufacture and commercialize our product candidates and to improve the manufacturing process, (v) the rate and degree of market acceptance of our product candidates, (vi) the size and growth potential of the markets for our product candidates and our ability to serve those markets, and (vii) our expectations regarding our ability to obtain and maintain intellectual property protection for our product candidates, are forward looking. All forward-looking statements are based on current estimates, assumptions and expectations by our management that, although we believe to be reasonable, are inherently uncertain. All forward-looking statements are subject to risks and uncertainties that may cause actual results to differ materially from those that we expected. Any forward-looking statement speaks only as of the date on which it was made. We undertake no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law. This presentation is not, and nothing in it should be construed as, an offer, invitation or recommendation in respect of our securities, or an offer, invitation or recommendation to sell, or a solicitation of an offer to buy, any of our securities in any jurisdiction. Neither this presentation nor anything in it shall form the basis of any contract or commitment. This presentation is not intended to be relied upon as advice to investors or potential investors and does not take into account the investment objectives, financial situation or needs of any investor. KIADIS PHARMA | www.kiadis.com 2

  3. Kiadis: Proprietary K-NK cell cancer immunotherapy K-NK cell therapy: K-NK pipeline: K-NK platform: Treatments across all Blood cancer and solid Off-the-shelf potent, high modalities, combining tumor cell-therapy dose NK cells based on strengths of innate and programs universal donor and haplo adaptive immune system donor • Salvage therapy: stand alone • K-NK002: Phase 1/2 as adjunctive • Off-the-shelf: mature universal • Front line therapy: adjunctive to to haplo HSCT with PTCy (2020) donor optimal for all patients • K-NK003: phase 1/2a to treat AML • PM21 particle platform : expansion surgery, chemo, MAbs, PARP • Preventive therapy R/R (2020) & activation with IL21 and 41bbL • K-NK00X: preclinical solid tumor programs HSCT: hematopoietic stem cell transplantation; Haplo: haploidentical (genetically half matched); allodepleted T-cells: T-cells without patient specific T-cells that could cause GVHD; GVHD: Graft versus Host disease; RMAT: Regenerative Medicine Advanced Therapy (‘breakthrough designation’); PTCy: post transplant cyclophosphamide KIADIS PHARMA | www.kiadis.com 3

  4. Kiadis K-NK Pipeline: Blood tumors and solid tumors, entering Phase 1/2 in 2020 PRE RE- PHAS ASE CATALYSTS IN PROOF OF F PR PROD ODUCT INDI DICATION SET SETTING CLI LINICAL PoC oC 1/2 1/2 2020 2020 CONCEPT Adjunctive to Phase 1/2 (63 25 patients: standard of care patients) start reduction of K-NK002 02 Blood cancer 2020 HSCT-PTCy with US BMT- relapse from (chemo) CTN 45% to 8% 13 patients: Stand alone K-NK003 03 AML R/R 2020 Phase 1/2a start 69% complete salvage therapy remission Combo with front Preclinical data; Preclinical data K-NK00X Solid tumors line therapy initiation new and literature (Mabs, chemo) trials KIADIS PHARMA | www.kiadis.com 4

  5. Combine innate and adaptive immunity Adaptive (IFN g ) MHC restricted Killing T cells killing (+receptors) NK cell Targeting CD8 Killing (ADCC) Tumor Ags Adaptive Antigen CD4 presentation DC B cell DC maturation selection and DC maturation Abs B cells KIADIS PHARMA | www.kiadis.com 5

  6. No need for CAR-engineering, NK cells naturally potent Issues CAR Issue CTL engineering HLA-1 down-regulation Toxicity and by tumor to escape mAb limited to single T-cells target CAR-T CD16 TCR NK-cell T-cell KIRXDSX GITR Stress/viral ligands (HLA independent) Activation Single antigen via HLA-1 or CAR-T ‘Self protection’ by recognition of HLA -1 Inhibition Checkpoints (HLA-1 independent) KIADIS PHARMA | www.kiadis.com 6

  7. Clinical benefit of combining NK-cells with antibody (ADCC) Outcomes for patients with high affinity CD16 (polymorphism in 10-15% of population) KIADIS PHARMA | www.kiadis.com 7

  8. Clinical benefit of giving NK cells after chemo CHEMO SENSITIZES TUMOR TO NK- PATIENT’S OWN NK CELLS NOT CHEMO INHIBITS NK CELL KILLING CELLS PRESENT OR P0TENT • Bortezomib (proteasome • Bortezomib leads to upregulation of • Lower numbers of NK cells in Multiple peripheral blood of patients 1, 2 myeloma inhibitor), inhibits NK cell killing NK cell receptor ligands, MICA and PVR, on tumor cells 1,6 and may interfere with NK cell – • Patient NK cells have low based immunotherapy 5 • Bortezomib and carfilzomib expression activating receptors and • Dexamethasone decrease inhibitory ligands, MHC, elevated expression of PD-1, a NK on tumor cells 7,8 inhibitory receptor 3,1 (glucocorticoid, often given with proteasome inhibitors), • NK activity and numbers is suppresses NK cell activity 14 associated with low tumor burden 4 • Paclitaxel and docetaxel • Docetaxel enhances NK mediated • Patients with large and locally Breast cancer (antimicrotubule drugs), may killing of tumor cells by advanced disease have lower interfere with NK cell – based upregulating activating ligands on absolute numbers of NK cells and immunotherapy by inhibiting tumor cell surface such as MICA, increased proportions of immature NK cell function 5 ULBP1-3 13 and non-cytotoxic NK cells 9,10 Multiple myeloma: 1. Mohyuddin et al, 2018 Advances in Cell and Gene Therapy; 2. Famularo et al, 1992 Journal of Clinical and Laboratory Immunology; 3. Fauriat et al, 2006 Leukemia; 4. Osterborg et al, 1996 European Journal of Hematology; 5. Markasz et al, 2007 Molecular Cancer Therapeutics; 6.Sorani et al, 2009 Immunobiology; 7. Shi et al, 2008 Immunobiology; 14. Chen et al, 2018 Inflammapharmacology Breast cancer: 8. Zang et al, 2015 Oncotarget; 9. Verma et al, 2015 Journal of Translational Medicine; 10.Mamessier et al, 2013 Journal of Immunology; 11.Chagollan-Garcia et al, 2018 Technology in Cancer Research and Treatment; 12. Zingoni et al, 2018 Frontiers in Immunology; 13. Acebes-Huerta et al, 2016 Oncoimmunology KIADIS PHARMA | www.kiadis.com 8

  9. Kiadis K-NK platform: addressing all NK critical attributes KIADIS PLATFORM BENEFITS • Hyperactive phenotype with high cytotoxicity 4-1bbL PM21 Potent, safe and antitumor IFNγ and TNF release (not (mbIL-21 and and persistent engineered) 41bbL particles) mbIL-21 • In vivo persistence (no senescence) • Fully licensed and mature NK cells Universal adult • Off-the-shelf Activating/inhibiting receptor profile optimized donor for all patients (HLA-KIR mismatch) • PM21 High yield/long culture allow high dosing and low Large scale (mbIL-21and COGS (>1000 doses/batch feasible) industrial • 41bbL Cryopreserved manufacturing • particles) No feeder/tumor cell materials in final product KIADIS PHARMA | www.kiadis.com 9

  10. K-NK cell industrial manufacturing platform with PM21 particles Day 0 - 7 Day 7 - 13 Day 14 Day 14 Xuri Acquisition Prodigy/Clinimacs+ Hollow fiber/Lovo ViaFreeze of donor GRex Expansion in a Harvest and Cryo- bioreactor cells from NK cell enrichment; concentration preservation the clinic Stimulation using Formulation in cryo- PM21 particles preservative PM21: mbIL-21 and 41bbL particles Native membrane particles presenting mbIL21 and 41bbL No intact tumor cells (regulatory) KIADIS PHARMA | www.kiadis.com 10

  11. Kiadis K-NK Clinical development outline PRODUCT INDICATION CLINICAL STUDIES Phase 1/2 BMT CTN Ph 2/3 Adaptive Design Blood K-NK002 (add-on bridge to OTS) versus PTCy cancer Ph 2/3 Adaptive Phase 1/2a K-NK003 AML R/R Design Phase 1 Phase 2a dose finding expansion & safety Phase 2 basket Phase 3 K-NK00X Solid tumors study indications Signal Activity studies 2024 KIADIS PHARMA | www.kiadis.com 11

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