Institute for Nuclear Research and Nuclear Energy: Present and - - PowerPoint PPT Presentation

Institute for Nuclear Research and Nuclear Energy: Present and Future

• Prof. Dimitar Tonev

Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences

INRNE-BAS TODAY

The biggest complex centre in Bulgaria for scientific and application investigations in the fields of:

• Nuclear physics
• Nuclear energy, nuclear methods and technologies
• High energy physics
• Radiation environment and ecology
• Theoretical and mathematical physics
• The research reactor of the INRNE-BAS
• Basic environmental observatory at peak Moussala
• Cyclotron laboratory
• World recognized results of the INRNE notified

during the European Science Foundation evaluation

• f the BAS.

Pro

• rof. Eli

lisaveta Karamihailo lova (1 (1897-1969) Pio ioneer of f th the Experimental Nucle lear r Physics in in Bulg lgaria

The group of Acad.

• W. Andrejtscheff is the

world leader in the field

• f lifetime

measurements!

On 18 june 2015 Thomson Reuters awards INRNE with first place for Essential Science Indicators for highly cited, top and hot papers.

THOMSON REUTERS

Bulgaria si since 1999 Member State of f CERN Member of f CMS si since 1991, CMS MoU si signed in in 1999

Scientists fro from IN INRNE are re actively participating in in Ex Experiments of f sy synthesis of f su super-heavy ele lements at t th the Nuclear Reaction Lab at t JI JINR-Dubna, Russia

Astroparticle physics, ground based gamma-ray astronomy of very high energies

INRNE is an official member of the big international collaboration MAGIC (Major Atmospheric Gama Imaging Cerenkov telescope) since 2005 via the Laboratory of Particle and Astroparticle Physics Scientific goals of MAGIC experiment:

• Discovery of the origin and acceleration mechanisms of Cosmic rays
• Search for Dark Matter, testing the fundamental laws and cosmological

models

• Discovery of new very high energy gamma-ray sources and detailed

investigation of known ones

IRT-200 Mission

 EDUCATION

 Nuclear energy, technology and investigations  Dosimetry, radiation protection  Physics, radiochemistry and radiobiology  Nuclear safety

 Applications

 Neutron activation analysis  Production of isotopes  Radio-pharmacy  Nanotechnology  Neutron radiography  New materials  Metrology

• 1956-1957 – training of

group Bulgarian scientists and engineers in

• peration of IRT in

Kurchatov Institute , Moskow: Simeon Ruskov, Vasil Hristov, Nikolay Buchvarov, Anton Markov, Ilija Mishev, Krikor Sakalijan and Dimitar Vatev.

The beginning

Before the Reactor construction, 1956 The Reactor under construction

IRT-2000 and related laboratories constituted a national centеr for scientific and applied research, as well as for education and training of specialists in the field of nuclear science and technology.

IRT-2000 Research Reactor

Russian and Bulgarian specialists taking part in the IRT-2000 start-up

First stage of the construction and commissioning of the Kozloduy NPP

13

30.06.1974 – Start up of unit 1 22.08.1975 – Start up of unit 2 The official opening of KNPP was on 4-th of September 1974

1970 – 1975 г. – construction of 1 and 2 unit

with pressurized water reactors type WWER-440, model V-230.

The State Enterprise Radioactive Waste started the construction of National Disposal Facility for Low- and Intermediate Level Radioactive Waste - 29.08.2017

Мисия ИРТ-200

 ОБУЧЕНИЕ

 Ядрена енергия, енергетика, технологии и изследвания  Дозиметрия, лъчезащита и лъчеинженерство  Физика и биология  Ядрена култура

 ПРИЛОЖЕНИЯ

 Неутронен активационен анализ  Производство на радиоизотопи  Радио-фармация  Облъчване на материали  Неутронна радиография  Материалознание  Метрология

Basic environmental observatory Peak Moussala-2928 m.

Laboratory for technical development - Physics

Radio ioactive tr transborder tr transfer: Fukushima

131I

0.1 0.2 0.3 0.4 8h 23.03 20h 24.03 8h 26.03 21h 27.03 8h 29.03 20h 30.03 8h 01.04 20h 02.04 8h 04.04 20h 05.04 8h 07.04

time, date, month mBq/m3 134Cs

0.01 0.02 0.03 0.04 0.05 0.06 8h 23.03 8h 24.03 8h 25.03 8h 26.03 9h 27.03 9h 28.03 8h 29.03 8h 30.03 8h 31.03 8h 01.04 8h 02.04 8h 03.04 8h 04.04 8h 05.04 8h 06.04 8h 07.04

time, date, month mBq/m3 137Cs

0.01 0.02 0.03 0.04 0.05 0.06 0.07 8h 23.03 8h 24.03 8h 25.03 8h 26.03 9h 27.03 9h 28.03 8h 29.03 8h 30.03 8h 31.03 8h 01.04 8h 02.04 8h 03.04 8h 04.04 8h 05.04 8h 06.04 8h 07.04

time, date, month mBq/m3

“Extreme external climate conditions”

IN INRNE and Str tress-tests of th the NPP “Kozloduy”

Optimization of nuclear fuel behavior for WWER-1000

19

Expert activ ivity

Scientific Support for Nuclear Energy, Research and expertise for Nuclear Safety of NPP, BNRA, NPP "Kozloduy“ EAD, Ministry

• f

energy, National electric company EAD, State Enterprise Radioactive Waste, and others.

The Cyclotron Laboratory at t IN INRNE-BAS

TR-24, ACSI(EBCO), Vancouver, Canada

TR-24, ACSI(EBCO), Vancouver, Canada

• Accelerates H- ions
• Extraction by stripping foils
• Beam Energy: 15 – 24 MeV
• Beam Current: 400 µA
• Upgradeable to 1 mA
• Dual Beam Extraction
• External CUSP ion source
• Turbomolecular and cryo vacuum

pumps

• Vacuum:5.10-7 – 10-6 Torr

PET: 11C, 13N, 15O, 18F, 124I, 64Cu, 68Ge SPECT: 123I, 111In, 67Ga, 57Co, 99mTc

Beamlines, targets and target stations for PET&SPECT radioisotopes production x 2 x 3 x 1

The TR Family of Cyclotrons

• TR-30 was designed at TRIUMF, Canada at the end of the 80's and has been manufactured since then by

ACSI(EBCO).

• Over 90% of all commercially supplied SPECT radioisotopes in North America, like 201Tl, 123I, 67Ga and 111In,

are PRODUCED on TR-30 cyclotrons.

• Since 1996 all 30 MeV cyclotrons for commercial production of SPECT radioisotopes installed in North America

are made by ACSI(EBCO).

• TR-30 cyclotrons have been operated 24/7 for 20+ years.
• In 2014 TRIUMF purchased a TR-24 cyclotron for its research program in radiopharmacy.

TR-19, 14-19 MeV, H-(D-)

TR-24, 15-24 MeV, H-

TR-30, 15-30 MeV, H-(D-)

Radiochemical Laboratories fo for Production of PET Radiopharmaceuticals

Equipment:

Hot Cells Synthesis modules Laminar Flowbox

The Cyclotron Labora ratory at IN INRNE-BAS

The aim is to establish a center for:

Applied Research R&D in Radiopharmacy Production of Radiopharmaceuticals Fundamental Science – Chemistry, Biology, Physics Training and Education in: Nuclear Energy; Radiochemistry; Radiopharmacy; Nuclear Physics; Radiation Protection.

Current use of medical radioisotopes

Diagnostics 95 %

Beta-emitters

186,188Re, 90Y, 186/188Re 177Lu, 131I, 165Dy 166Ho, 105Rh, 111Ag

Alpha-emitters

212Bi, 213Bi, 211At 255Fm, 225Ac, 223Ra

Brachytherapy

192Ir, 182Ta, 137Cs 103Pd, 125I, 60Co

SPECT

99mTc, 111In, 123I, 201Tl, 67Ga

PET

18F, 11C, 13N 15O, 68Ga, 64Cu 86Y, 89Zr, 124I

Purpose

44Sc / 47Sc 64Cu / 67Cu 86Y / 90Y 124I / 123/131I 67/68Ga / 111In 99mTc / 186/188Re 68Ga / 67Ga

in-vitro

3H, 14C 32P, 125I

Theranostics Therapy 5% Theranostics = Therapy + Diagnostics

№1: 99Mo/99mTc №2: 18F

30

Cyclotron Vault Layout A tender procedure for a project of the building is going to finish yesterday, 11.09.2018

⁶⁸Ga 31p 37n

 Probability Mode Decay Energy Daughter  100.% β+ 1898.9keV ⁶⁸Zn  Yield Nuclide  100.% ⁶⁸Zn  Atomic Weight 67.927980084  Abundance None  Mass Excess -67.08612MeV  Binding Energy 8.70122MeV

⁶⁸Ga as a radiopharmaceutical

 ⁶⁸Ga in clinical trials proves itself to be a good contender for replacement of the currently used radionuclide pharmaceuticals (111In) and gives a great opportunity for optimization of treatments and imaging methods.  Its shorter half-life of 68 minutes allows for faster clearance from the organism and it makes it possible to use on the same patient with a shorter waiting period in between application.

• Fig. 1 A middle-aged patient has an 111In-DTPA-octreotide SPECT/CT scan

demonstrating a focus of uptake in a 1 cm right lower quadrant mesenteric lymph node (arrow, A and C). There is trace uptake in a normal sized (5 mm) peri-pancreatic lymph node (B) that prospectively was read as normal. Fig.2 68Ga-DOTATATE PET/CT scan performed prior to surgery revealed the already known right lower quadrant lymph node (D and F) as well as clear-cut intense uptake in the peri-pancreatic lymph node (E) that was read earlier as

• normal. The surgical plan was changed to extent the field to include resection

confirmed metastatic disease.

INRNE and National Scientific Road Map

• National cyclotron center
• EURATOM–INRNE
• CTA-MAGIC
• ACTRIS
• CERN
• JINR

11 - EURATOM 8 with JINR, Dubna 6 - JRC 5 - “Res. infrastructures” 1 - “Environment” 1 - MCA IRSES 1 - ERA NET 3 – COST And more

Pro rojects

United We Stand Strong

Bulgarian Presidency of the Council of the EU 1 January – 30 June 2018

We shall finish what we started together

• Council Conclusions on

a reformed ITER project

• the

way forward

ITER, means „passage” from latin – the aims are to contribute to a much faster realization of the prospect that most of our electricity needs will be covered by fusion.

• Extension
• f

the EURATOM Programme for research and training during 2019- 2020

ITER: An unprecedented international collaboration

• Council Conclusions on a reformed ITER project -

the way forward

• Extension
• f

the EURATOM Programme for research and training during 2019-2020

• Research and Innovation for Food and Nutrition

Security and Quality Empowerment

Research and Innovation: Priority topics

Work rkshops and confere rences,

• rg

rganized by IN INRNE

INRNE organized many workshops and conferences on nuclear physics, nuclear theory, fuel modelling (WWER), quantum systems

Thank you!