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Episode #262
EBM
Conscientious Explicit Judicious Best Evidence Individual Patients
David Sackett
Episode #262 EBM Conscientious Explicit Judicious Best Evidence - - PowerPoint PPT Presentation
Episode #262 EBM Conscientious Explicit Judicious Best Evidence - - PowerPoint PPT Presentation
Episode #262 EBM Conscientious Explicit Judicious Best Evidence Individual Patients David Sackett EBM Sackett et al BMJ 1996 Levels of Evidence Systematic Review Appraised Topics Appraised Article RCT Cohort Study Case Report
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Sackett et al BMJ 1996
EBM
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Levels of Evidence
Systematic Review Appraised Topics Appraised Article RCT Cohort Study Case Report Expert Opinion
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4
SGEM Xtra:
Make it So
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EBM is the Worst…
"Democracy is the worst form of government except all the others that have been tried." Sir Winston Churchill
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EBM has Been Hijacked: Ioannidis JP . J Clin Epi 2016
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- DR. EVIL
Bekelman et al JAMA 2003 Okike et al Injury 2008 Lundh et al Cochrane 2013
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Study Designs
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ITT vs. PP Analysis
Draw your own conclusions
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the future is open
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SGEM#262: Omadacycline
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Guest Skeptic: EM Swami
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New York ACEP Scientific Assembly
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Case
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SGEM#: 13, 131, 156, 164 and 209
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O’Riordan et al NEJM 2018 “Omadacycline was noninferior to linezolid for the treatment of acute bacterial skin and skin-structure infections and had a similar safety profile”
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4
SGEM Xtra:
Make it So
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Omadacycline was non-inferior to linezolid
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- Funding
- Selection Bias
- Non-Inferiority
- ITT vs. PP
- Why Linezolid?
T a l k N e r d y T
- M
e
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SGEM Bottom Line
Omadacycline is not recommended for the routine use in SSTI
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Remember to be skeptical of anything you learn, even if you heard it on the Skeptics’ Guide to Emergency Medicine.