Dual Diagnosis: Assessment, Diagnosis, and Treatment Michael S. - - PDF document

Dual Diagnosis: Assessment, Diagnosis, and Treatment

Michael S. Marcin, MD, MSCR

Associate Clinical Professor, UCSF Assistant Medical Director, AIP LPPI March 4, 2016

2

Financial Disclosure:

I have nothing to disclose.

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Gratitude:

• Patients, families and caregivers
• Andrew Booty
• Gerri Collins-Bride
• Jim Bourgeois
• Clarissa Kripke
• Gaelen Lombard
• Matthew State
• My Colleagues at GGRC and ARC

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Comments about Presentation

• We have a discussion panel following this,

which is a great time to ask more involved

• questions. Please ask if a slide needs

clarification.

• Most of the data for the many studies

presented are based in the DSM-IV not the DSM-5.

• Nearly all of this presentation is based on
• ther people’s hard work. Please see the

slide-by-slide Reference Handout provided

• today. Readability of slides was my main

goal for this PPT.

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Presentation Outline

• Working Assumptions
• What is Dual Diagnosis?
• Problem Behaviors vs. Psychiatric

Disabilities/Disorders

• Why are We Talking about Dual

Diagnosis?

• Assessment Tools
• Somatic Treatment Options

6

Presentation Outline

• Working Assumptions
• What is Dual Diagnosis?
• Problem Behaviors vs. Psychiatric

Disabilities/Disorders

• Why are We Talking about Dual

Diagnosis?

• Assessment Tools
• Somatic Treatment Options

7

Working Assumptions

• Individuals with Dual Diagnosis are

INDIVIDUALS

• Seeing persons with DD as anything other than

entire persons leads us astray

• Individuals, Providers and Caregivers are doing

the best they can on a daily basis

• Looking at available, high quality research data

provides an anchor in decision making

• There is a lack of this data across the spectrum
• f persons with ID as well as persons with PD

and especially for those with both, DD.

• Yet, progress is being made

8

Presentation Outline

• Working Assumptions
• What is Dual Diagnosis?
• Problem Behaviors vs. Psychiatric

Disabilities/Disorders

• Why are We Talking about Dual

Diagnosis?

• Assessment Tools
• Somatic Treatment Options

9

Defining Dual Diagnosis (? + ? = DD)

• Intellectual disability in DSM-5 involves mental

impairments that affect adaptive functioning in three domains impacting completion of everyday tasks: – Conceptual domain: skills in language, reading, writing, math, reasoning, knowledge, and memory. – Social domain: “empathy, social judgment, interpersonal communication skills, the ability to make and retain friendships, and similar capacities.” – Practical domain: “self-management in areas such as personal care, job responsibilities, money management, recreation, and organizing school and work tasks.”

• http://www.dsm5.org/documents/intellectual%20disability

%20fact%20sheet.pdf

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Defining Dual Diagnosis (? + ? = DD)

• Psychiatric Disability/Disorder: Clinically significant

disturbance in cognitive, emotional regulation, and behavior that represents a disturbance in mental functioning that leads to struggles with work, school, family or other social arenas. (DSM 5, American Psychiatric Association, 2013, p.20)

• Neurodevelopmental Disorders: Intellectual Disabilities +

Communication Disorders + Autism Spectrum Disorder + AD/HD + Specific Learning Disorder + Motor Disorders + Other Neurodevelopmental Disorders

• Basically: PD= All DSM 5 diagnoses – some

Neurodevelopmental Disorders but keeping others

• Now, you know why everyone is so confused

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Defining Dual Diagnosis (? + ? = DD)

• "Dual diagnosis is a conceptualization of comorbidity in

adults with an intellectual disability. Co-morbidity refers to the presence of at least two distinct and separate disabilities or pathologies in the same individual. First utilized in the US during the 1970s, dual diagnosis was used to describe mental health problems in adults with an intellectual disability. The term dual diagnosis specifically refers to coexisting intellectual disability and mental disorder.“

• Dual Diagnosis= ID +/- Autism + other DSM 5 non-

Neurodevelopmental Disorders

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Presentation Outline

• Working Assumptions
• What is Dual Diagnosis?
• Problem Behaviors vs. Psychiatric

Disabilities/Disorders

• Why are We Talking about Dual

Diagnosis?

• Assessment Tools
• Somatic Treatment Options

13

Defining Problem Behaviors AKA Challenging Behaviors (PB/CB)

• People with intellectual disabilities are at higher risk for

developing behavior problems.

• Studies have reported that 7–15% of individuals with ID

who receive services have severe behavior problems. Thus, 85–93% of people with ID do not show severe behavior problems, regardless of what level of their ID.

• Types of PB/CB are: “aggression towards others, temper

tantrums, screaming or shouting, and self-injury”

• “Several authors have suggested that behavior problems

may be indicators of psychiatric disorders in individuals with intellectual disability”

• There is a higher incidence of PD in persons with ID who

also have PB/CB compared to those without challenging behavior.

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Defining Problem Behaviors AKA Challenging Behaviors (PB/CB)

• In individuals with ID, physical aggression was associated

with a 50% probability of PD.

• The presence of PB/CB increased the probability of

almost all psychiatric conditions.

• Several research studies suggest that in persons with ID

there is a strong relation between behavior problems and psychiatric disorders in individuals with intellectual disability

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Other Correlations: Level of ID, Symptoms of PD and PB/CB

• More symptoms of PD in those with mild and moderate

than those classified as severe and profound ID.

• Those classified as mild/moderate had more symptoms of

psychosis and depression than those classified as severe/ profound, while other symptoms of PD were more evenly distributed regardless of classification of ID.

• Interesting Correlation Between PD and PB/CB:

– anxietytantrums – maniatantrums, aggression and screaming – weakest correlation: self-injurious behavior (SIB) – depression aggression, tantrums and screaming in those classified as severe and profound – depression tantrums and SIB, mild and moderate ID

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Hypotheses of Link

• PB/CB may have the same roots that express

itself differently sometimes as PD

• Challenging behavior may be an expression of

mental illness

• Challenging behaviors may occur in an attempt

to stop aversive experiences in PD

19

Presentation Outline

• Working Assumptions
• What is Dual Diagnosis?
• Problem Behaviors vs. Psychiatric

Disabilities/Disorders

• Why are We Talking about Dual

Diagnosis?

• Assessment Tools
• Somatic Treatment Options

20

Why focus on Dual Diagnosis?

• Average life expectancy of people with ID is around 60
• years. But, for those individuals with mild ID free of

comorbid PD, their lives are as long as neurotypical individuals.

• Many studies show that for children and adolescents with

ID between 30 and 50% have comorbid PD with a relative risk of having PD with ID of 2.8–4.5.

• The mental well-being of parents of children with ID is

more affected by their children’s severity of PD than that

• f the severity of ID
• Adults with ID experience comorbid PD at higher rates

than other adults; point prevalence is approximately 40% with annual incidence at about 8%

21

Why focus on Dual Diagnosis?

• The 1995 Welsh Health Survey found that persons with ID

had a higher rate of psychiatric illness (32.2%) than the general population (11.2%).

• People with ID disproportionately contribute to total

psychiatric morbidity. Emerson and Hatton in 2007 estimated that the 3% of British children with ID account for 14% of total child and adolescent psychiatric morbidity

• “Psychosocial masking”
• “Cognitive disintegration”

22 23

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Examples of Specific Psychiatric Disabilities/Disorders Rates

• 2005 Australian Study looking at the ‘Disability, Ageing

and Carers Survey, 1998’ comprising data on 42,664 adults living at home or in care facilities. The prevalence

• f ID was 1.25%. Rates for disabling comorbid PD were:

1.3% psychosis, 8% depression, and 14% had an anxiety

• disorder. (E9)
• Two more studies reported a point prevalence of 3% and

2.7% respectively for schizophrenia compared to 0.4% in the general population

• Interestingly, in another study the point prevalence of

depressive disorder ranged up to 3.7%, which is just over a fourth in the general population

25

How Does Ageing Affect Those with Intellectual Disability?

• Londoners with ID who are 65 and older showed PD in

74% of those surveyed.

• Those with Down’s Syndrome have higher rates of
• dementia. In those 65 years or over, 18.3% had dementia,

which is 3.9x higher than general population.

• Down’s Syndrome and dementia is associated with more

frequent and severe PB/CB

• Dementia progression in people with Down’s Syndrome

was demonstrated to be: 45 “to 49 years – 16.8%; 50–54 years – 17.7%; 55–59 years – 32.1%; 60 years plus – 25.6%.

• Increased mortality in those with dementia (44.4%)

compared with those without dementia (10.7%).

26 27

28

Dual Diagnosis in Autism

• Higher parent and teacher ratings for ADHD, ODD,

aggression, anxiety, and depression compared with neurotypical students.

• Preschoolers through young adults: elevated behavior

problems, anxiety, depression, irritability compared to control group. Individuals without ASD but with ID had lower rates of same behaviors when compared with individuals with autism.

• Hurtig et al. (2009) reported greater anxiety, depression,

and attention problems in 43 adolescents with HFA/Asperger’s disorder than controls.

29

Dual Diagnosis in Autism

• A study of 177 children with autism showed elevated

scores: 26% depression, 25% anxiety, 25% ADHD, 16% conduct disorder, and 15% oppositional- defiant disorder.

• Youth with autism (combining results from two studies):

– 8-44%for specific phobia, 29% social anxiety disorder – 8-37%for OCD, – 10% panic disorder, 8% agoraphobia – 2-13% for generalized anxiety disorder – 28-31% for ADHD, – 13% for depression, – 12% for separation anxiety disorder, – 7-28% for oppositional-defiant disorder, – 3% conduct disorder

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31 32 33

34

Presentation Outline

• Working Assumptions
• What is Dual Diagnosis?
• Problem Behaviors vs. Psychiatric

Disabilities/Disorders

• Why are We Talking about Dual

Diagnosis?

• Assessment Tools
• Somatic Treatment Options

35

What is an Ideal Assessment?

• Avoid “Diagnostic Overshadowing”
• Use multi-method approach evaluating mood, personality,

social skills and aberrant behavior

• Review of the client/patient’s records: medical

information, illnesses, injuries, recent trauma events, past effective interventions

• Interviews with the individual, parents, teachers, and

caregivers asking baseline/changes in adaptive functioning: changes in interpersonal skills, relationships,

• r communication skills, as well as in daily functioning.
• Observations—frequent behaviors vs. infrequent
• behaviors. Two methods for infrequent behaviors:

Antecedent Behavior Consequence (ABC) and the scatterplot (formal and Calendar Method)

• Use Rating Scales

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Rating Scales: The Gold Standards for Self and Caregiver Reports

• PIMRA: The Psychopathology Instruments for Mentally

Retarded Adults

• DASH II: The Diagnostic Assessment for the Severely

Handicapped Scale

• ADD: Assessment of Dual Diagnosis
• RSMB: The Reiss Screen for Maladaptive Behavior
• RSCDD: The Reiss Scales for Children’s Dual Diagnosis
• **CBRF: The Nisonger Child Behavior Rating Form
• DBC: The Developmental Behavior Checklist
• PAS-ADD Checklist: Psychiatric Assessment Schedules

for Adults with Developmental Disabilities Checklist

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Rating Scales: The Challengers to the Gold Standards

• CBCL: Child Behavioral Checklist
• GDS-LD: The Glasgow Depression Scale for people with

a Learning Disability

• CDI: The Children’s Depression Inventory (CDI)
• BDI: Beck Depression Inventory
• GAS-ID: Glasgow Anxiety Scale for people with an

Intellectual Disability

• ADAMS: Anxiety, Depression and Mood Scale

41

Presentation Outline

• Working Assumptions
• What is Dual Diagnosis?
• Problem Behaviors vs. Psychiatric

Disabilities/Disorders

• Why are We Talking about Dual

Diagnosis?

• Assessment Tools
• Somatic Treatment Options

42

Outline for Somatic Treatments

• General guidelines for Somatic Treatments
• Need to acknowledge that there is evidence for

medication treatment of PD

• But need to recognize that most of the recent

evidence-based treatments for DD have come from studies of youth with ASDs and mostly targeting PB/CB not formal PD in DD

• Following is a series of slides that summarizes

most of the recent relevant somatic treatment studies in youth with ASD

• Also follows is an additional series of slides that

identify common somatic treatments with sufficient evidence to support treatment of DD

43

Somatic Treatment of PD in DD

• Know what you are treating
• Know what you want to happen with treatment
• Use Scales to help identify PD and response to

treatment

• Use Scatterplot, Calendar Method, or ABC

graphs to understand targets of treatment

• First line treatment should involve behavioral

and environmental interventions

• If you need to use medications:

– Watch for side effects – Only use evidenced-based treatments when you can.

44

Somatic Treatment of PD in DD

"Psychotropic medications…have side effects that [may] be harmful to the physical health of the individuals who take them, such as gait disorder, tardive dyskinesia, diabetes mellitus, tics, hair loss, acne and weight gain. The recognition of side effects is especially challenging because of the cognitive and self-awareness limitations of many individuals.”

• Henry Kwok and Patrick W.H. Cheung. Comorbidity of

Psychiatric Disorder and Medical Illness in People with Intellectual Disabilities. Curr Opin Psychiatry 2007; 20:443-449.

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Brief Summary of Evidence in Autism Spectrum Disorders

• Atypical Antipsychotics can be used to treat

irritability (aggression, self-injury, and severe tantrums), stereotypies, and hyperactivity: risperidone and aripiprazole are best.

• Methylphenidate, atomoxetine, clonidine and

guanfacine are effective in reducing ADHD symptoms

• SSRIs are not effective in reducing repetitive

behaviorsactivation

• Anti-epileptic drugs (AEDs) have mixed results
• N-acetylcysteine (NAC) found to be helpful in

improving irritability in children with ASD

46

Treatments Currently Under Investigation with RDBPCT

• Oxytocin
• Glutamatergic agents
• Vasopressin
• Donepezil
• Oxidative stress pathways:

– Sulforaphane, – terahydrobiopterin, – L-carnitine and – methyl-B12

51

Insomnia Is a Problem in ID

• ASD (50-80%): see melatonin study
• Angelman Syndrome (20–80%): likely sensitive to

GABAergic agents

• Cerebral Palsy: pay attention to sleep apnea,

possible role for melatonin

• Rett Syndrome (80%): hard to treat due to medical

complications

• Williams Syndrome: significantly more daytime

sleepiness

• Smith-Magenis: possible role for melatonin
• In a survey of Child and Adolescent Psychiatrists,

30% of those with ID were being treated for insomnia

A Closer Look at Specific Somatic Treatments

56 57

Class: Antipsychotics

• Generic Name: Risperidone
• Known for: Irritability in autism, class problems

with weight gain, movement disorders, lipid issues, metabolic syndrome/diabetes; increased prolactin levels

• FDA Approvals: Adult and child Schizophrenia

and Bipolar I Disorder, acute manic/mixed; Irritability associated with Autism in children and adolescents

58

Class: Antipsychotics

• Generic Name: Risperidone (continued)
• Evidence for DD: (RDBPCT)
• High doses effective for reduction in irritability,

stereotypy, and hyperactivity in ASD

• Long-term effects maintained in ASD
• Combo of risperidone/parent-training more effective

in ASD

• Risperidone and aripiprazole are equal in ASD
• Tryer et al. in an RPCT showed placebo to be better

than risperidone and haloperidol in reducing aggression in non-psychotic adult patients with DD.

• Risperidone was safe and remained effective after
• ne year in disruptive behavior disorders in children

with low IQs who did not have ASD.

59

Class: Antipsychotics

• Generic Name: Aripiprazole
• Known for: Irritability in autism, class problems with

weight gain, movement disorders, lipid issues, metabolic syndrome/diabetes

• FDA Approvals: Adult and child/adolescent for

Schizophrenia, Bipolar I Disorder (manic/mixed); Adult treatment for Major Depressive Disorder (adjunctive treatment); and child/adolescent for irritability associated with ASD, Tourette Syndrome

• Evidence for DD: (RDBPCT)
• Reduced irritability, stereotypy, and hyperactivity in ASD
• Long-term effect maintained in ASD
• Increased weight, dyslipidemia, and aggression were

common, especially in antipsychotic-naïve youth with baseline weight issues

• Risperidone=aripiprazole in ASD

60

Class: Antipsychotics

• Generic Name: Olanzapine
• Known for: large amount of weight gain in

addition to typical class concerns

• FDA Approvals: Adult Schizophrenia, Bipolar I

Disorder (manic/mixed/agitation/acute depression), Major Depressive Disorder, acute treatment resistant. In children/adolescents approved for Bipolar I Disorder (manic/mixed) and Schizophrenia

• Evidence for DD: (RDBPCT)
• Was effective in improving aggressive behavior

in ASD, but with large amount of weight gain

61

Class: Antipsychotics

• Generic Name: Haloperidol
• Known for: Highly potent and specific to D2

receptors; movement disorders and associated class side effects

• FDA Approvals: Adult and child and adolescent

psychosis and Tourette Syndrome; child and adolescent severe behavioral problems

• Evidence for DD: (RDBPCT)
• Improved aggressive behaviors but higher risk than

risperidone and aripiprazole

• Tryer et al. in an RPCT showed that placebo was

better than both risperidone and haloperidol in reducing aggression in non-psychotic adult patients with DD.

62

Class: Antipsychotics

• Generic Name: Quetiapine
• Known for: Sedation, orthostatic hypotension

in addition to other class side effects

• FDA Approvals: Adult and child/adolescent

treatment for Schizophrenia and Bipolar I Disorder (mania); also adult approved for Bipolar I Disorder (depression)

• Evidence for DD: (Open label studies)
• Poor efficacy and poor toleration of side effects

in ASD

63

Class: Antipsychotics

• Generic Name: Ziprasidone
• Known for: More weight neutral in adults, but need

to pay attention to QTc

• FDA Approvals: Schizophrenia, Bipolar I Disorder

(manic/mixed)

• Evidence for DD: (Open label studies)
• In one retrospective naturalistic study 49%

responders on Clinical Global Impressions- Improvement Scale (CGI-I) for ASD

• Another small study had 75% responders on CGI-I

for ASD

• Another small open label study had 60% responders
• n the Maladaptive Behavior Scale and they lost

weight gained from other meds

64

Class: Antipsychotics

• Generic Name: Clozapine
• Known For: Can have amazing results in
• Schizophrenia. Many worrisome side effects

including collapse of the immune system; requires weekly labs for a year to check white blood count

• FDA Approval: Adults with Refractory

Schizophrenia and Schizophrenia-associated Suicide Prevention

• Evidence for DD:
• Inconclusive at best for managing aggression in

adults with ID

65

Class: ADHD Medication

• Generic Name: Methylphenidate
• Known for: One of most effective ADHD tx,

common side effects: weight loss, anger, poor sleep

• FDA Approvals: Adult and child/adolescent ADHD,

Adult Narcolepsy

• Evidence for DD: (RDBPCT)
• Only stimulant studied in ASD
• Effective for ADHD treatment in youth with ASD
• Less effective than in typically developing children

with ADHD

• Aman et al. analyzed three studies demonstrating

that children with ADHD and ID have significant improvements in children, less so with lower IQs

66

Class: ADHD Medication

• Generic Name: Atomoxetine
• Known for: Non-stimulant. Also helpful for ADHD +

anxiety

• FDA Approvals: ADHD in both adults and youth
• Evidence for DD: (RDBPCT)
• Effective in ADHD in those with ASD
• Atomoxetine plus parent training was more effective

than med or parent training alone in ADHD in those with ASD

67

Class: HTN Meds for ADHD

• Generic Name: Clonidine and Guanfacine (similar

meds)

• Known for: Alpha 2-agonist. It can also treat tics,

insomnia, Tourette’s, agitation. Also, lowers blood pressure, sedating, rebound hypertension

• FDA Approvals: Adult Hypertension; Adult and child

and adolescent Severe Cancer-Related Pain, adjunctive treatment; Children and adolescent ADHD

• Evidence for DD: (RDBPCT)
• Effective for ADHD symptoms in children with ASD

68

Class: SSRI Antidepressants

• Generic Name: All SSRIs (Selective Serotonin

Reuptake Inhibitors)

• Known for: Black Box warning for Suicidal Ideation,

some weight gain, activation of mania or aggression

• FDA Approvals: Numerous for depressive/anxiety

disorders in both adults and youth

• Evidence for DD:
• For core symptoms of ASD ineffective and possibly

activating and aggression inducing (RDBPCT)

• Aman et al. in a review of many open label studies

that these meds were indeed useful in anxiety and depression in DD.

69

Class: SSRI Antidepressants

• Continued from prior slide
• Evidence for DD:
• Open label citalopram study found 60% of

patients with ID and depression improved on the Clinical Global Improvement Scale (CGIS)

• In an open retrospective study of adults with DD,

Ulzen and Hughes demonstrated an overall rate

• f 12.3% activation into hypomania compared to

the general population rate of 0.5–1%.

70

Class: Non-SSRI Antidepressants

• Generic Name: Clomipramine
• Known for: Gold Standard for OCD, lots of

potential side effects

• FDA Approvals: Adult and child and adolescent

OCD

• Evidence for DD: (RDBPCT)
• In youth with ASD, not well tolerated and not

enough evidence to use

• In adults with ASD, effective for stereotypies,

anger, compulsions/ritualized behaviors, and hyperactivity

71

Class: Mood Stabilizer

• Generic Name: Lithium
• Known For: Classic treatment for mania. Side

effect profile that is well-understood.

• FDA Approval: Bipolar Disorder I (mania, acute

and maintenance) for both adults and children

• Evidence for DD:
• Two studies dating back to 1987 and 1993

showing up to a 77% response rate in individuals with both ID and Bipolar Disorder (RCT & RDBPCT)

• Retrospective chart review found lithium to be

43% to 71% effective in children who had ASD and mood disorder symptoms

72

Class: Anti-Epilepsy Drug (AED)

• Generic Name: Divalproex Sodium
• Known for: It is used commonly in seizure

control, Bipolar Disorder and aggression. More worrisome in females of child-bearing age.

• FDA Approvals: Seizures in both adults and

youth; Adults only for Bipolar I Disorder (manic), and Migraine

• Evidence for DD: (RDBPCT)
• Maybe? in treatment of irritability in ASD
• Kotsaftis reviewed 17 open label studies

showing that 77% of patients’ manic/aggressive behavior responded

73

Class: Anti-Epilepsy Drug (AED)

• Generic Name: Topiramate
• Known for: It is used commonly in seizure

control and migraine treatment. May help with weight gain when on antipsychotics, but with

• ther complications
• FDA Approvals: Adults and youth for Seizures

and Migraine prophylaxis

• Evidence for DD: (RDBPCT)
• In combination with risperidone it may help with

PB/CB in children with ASD

74

Class: NMDA receptor modulators and antagonists

• Generic Name: N-acetylcysteine ( NAC),

amantadine, riluzole and memantine

• Known for: Tylenol overdoses,

Trichotillomania, OCD, ADHD?, flu, ALS, dementia and Parkinson’s Disease treatment

• Evidence for DD: (RDBPCT)
• NAC found to be helpful in improving irritability

in children with ASD

• Amantadine, riluzole and memantine ineffective

as single agent in several trials

• Yet, may be effective in combo with

antipsychotics in improving behavioral measures in children with ASD

75

Class: Alzheimer’s Dementia/Cholinesterase Inhibitor

• Generic Name: Donepezil
• Known for: Alzheimer’s treatment
• FDA Approvals: Alzheimer Dementia
• Evidence for DD: (RDBPCT)
• Two trials with mixed results in core features of

ASD

• Ongoing trials currently

76

Class: Opioid Antagonist

• Generic Name: Naltrexone
• Known for: Treatment for Substance Abuse

disorders

• FDA Approvals: Opioid Addiction and Alcohol

Dependence

• Evidence for DD:
• No good clinical trials to support treatment of

SIB in those with ASD

• But, Roy et al, reviewed 10 RDBPCT and

reported that there may be evidence for improvement for hyperactivity and restlessness in children with ASD

77

Class: Sedative Hypnotic

• Generic Name: Melatonin
• Known for: Effective with sleep; some

experience possible nightmares, Non-FDA regulated OTC supplement

• FDA Approvals: Circadian Rhythm Sleep

Disorder in Blind Children and adults

• Evidence for DD: (RDBPCT)
• Melatonin plus CBT found to help with insomnia

(better than CBT alone)

• See Slide 55 for three more trials

78

Class: ECT Treatment

• Indications: Severe/Resistant Depression,

Severe Mania, Catatonia, PB/CB in people with

• Dementia. Useful in pregnant patients when

medications are considered unsafe

• Kessler [32] reviewed 16 case reports between

1968 and 2001 of ECT in patients with ID and a variety of PD.

• The treatment was successful despite failures
• n all prior medication treatments
• No significant complications
• No cognitive decline from the treatment

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Dual Diagnosis: Assessment, Diagnosis and Treatment Michael S. Marcin, MD, MSCR References Organized by Slides

Slide 13: Myrbakk & Tetzchner. Psychiatric disorders and behavior problems in people with intellectual disability. Research in Developmental Disabilities; 29:316-332; 2008. Emerson, E. Challenging behaviour: Analysis and intervention in people with learning difficulties. Cambridge, UK: Cambridge Press; 2001. Emerson et al. The prevalence of challenging behaviors: a total population study. Research in Developmental Disabilities; 22:77-93; 2001. Moss et al. Psychiatric symptoms in adults with learning disability and challenging behaviour. British Journal of Psychiatry; 177: 452-456; 2000. Slide 14: Myrbakk & Tetzchner. Psychiatric disorders and behavior problems in people with intellectual disability. Research in Developmental Disabilities; 29:316-332; 2008.

Matson & Mayville. The relationship of functional variables and psychopathology to aggressive behavior in persons with severe and profound mental retardation. Journal of Psychopathology and Behavioral Assessment; 23:3-9; 2001. Rojahn et al. Relationships between psychiatric conditions and behavior problems among adults with mental retardation. American Journal on Mental Retardation; 109:21-33; 2004.

Slide 15, 16 & 17: Myrbakk & Tetzchner. Psychiatric disorders and behavior problems in people with intellectual disability. Research in Developmental Disabilities; 29:316-332; 2008.

2 | P a g e Slide 18: Emerson E, Moss S, Kiernan CK. The relationship between challenging behavior and psychiatric disorders in people with severe intellectual disabilities. In Bouras N (Ed.), Psychiatric and behavioral disorders in mental retardation. Cambridge: Cambridge University: 38-48; 1999. Slide 20: Patja K et al. Life expectancy of people with intellectual disability: a 35-year follow-up study. Journal Intellectual Disability Research; 44:591-599; 2000.

Stewart et al. Comorbidity of intellectual disability and mental disorder in children and adolescents: a systematic review. Journal of Intellectual and Developmental Disability; 36:2:137-143; 2011. Tonge & Einfeld. Psychopathology and intellectual disability. The Australian Child to Adult Longitudinal

• Study. In L. M. Glidden (Ed.), International review of research in mental retardation. San Diego: Academic

Press: Vol 26:61-91; 2003. Smiley E et al. The incidence and predictors of mental ill-health in adults with intellectual disabilities. Prospective Study. British Journal of Psychiatry; 191:313-319; 2007. Slide 21: Kwok & Cheung. Co-morbidities of psychiatric disorder and medical illness in people with intellectual

• disabilities. Current Opinion in Psychiatry; 20:443-449; 2007.

Stewart et al. Comorbidity of intellectual disability and mental disorder in children and adolescents: a systematic review. Journal of Intellectual and Developmental Disability; 36:2:137-143; 2011. Costello & Bouras. Assessment of Mental Health Problems in People with Intellectual Disabilities. Isr J Psychiatry Relat Sci; 43:4:241-251; 2006. Slide 22: Emerson E. et al. The mental health of young children with intellectual disabilities or borderline intellectual

• functioning. Soc Psychiat Epidemiology; 45:579-587; 2010.

Slide 23: Smiley E et al. The incidence and predictors of mental ill-health in adults with intellectual disabilities. Prospective Study. British Journal of Psychiatry; 191:313-319; 2007.

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Slide 24: White P et al. Prevalence of intellectual disability and comorbid mental illness in an Australian community

• sample. Australian and New Zealand Journal of Psychiatry; 39:395-400; 2005.

Costello & Bouras. Assessment of Mental Health Problems in People with Intellectual Disabilites. Isr J Psychiatry Relat Sci; 43:4:241-251; 2006. Slide 25: Strydom et al. Mental health and social care needs of older people with intellectual disabilities. J Appl Res Intellect Disabil; 18:229-235; 2005. Torr & Davis. Ageing and mental health problems in people with intellectual disability. Current Opinion in Psychiatry; 20:467-471; 2007. Huxley A et al. A comparison of challenging behaviour in an adult group with Down’s syndrome and dementia compared with an adult Down’s syndrome group without dementia. Br J Learn Disabil; 33:188- 193; 2005. Patti, PJ et al. Life events in older adults with intellectual disabilities: differences between adults with and without Down syndrome. J Policy Pract Intellect Disabil; 2:149-155; 2005. Slide 26 & 27: Einfeld et al. Psychopathology in Young People with Intellectual Disability. JAMA; 296(16): 1981-1989; 2006. Slide 28: Gadow et al. Psychiatric symptoms in preschool children with PDD and clinic and comparison samples. Journal of Autism and Developmental Disorders; 34:379-393; 2004. Gadow et al. Comparison of DSM-IV symptoms in elementary school-aged children with PDD versus clinic and community samples. Autism; 9:392-415; 2005. Mayes et al. Anxiety, depression, and irritability in children with autism relative to other neuropsychiatric disorders and typical development. Research into Autism Spectrum Disorders; 5:474-485; 2011. Hurtig et al. Multi-informant reports of psychiatric symptoms among high-functioning adolescents with Asperger syndrome or autism. Autism; 13:583-598; 2009.

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Slide 29: Kanne et al. Multi-informant ratings of psychiatric symptom severity in children with autism spectrum disorders: The importance of environmental context. Journal of Autism and Developmental Disorders; 39:856-864; 2009. Leyfer et al. Comorbid psychiatric disorders in children with autism: Interview development and rates of

• disorders. Journal of Autism and Developmental Disorders; 36:849-861; 2006.

Simonoff et al. Psychiatric disorders in children with autism spectrum disorders: Prevalence, comorbidity, and associated factors in a population-derived sample. Journal of the American Academy of Child and Adolescent Psychiatry; 47:921-929; 2008. Slide 30 & 31: Mayes et al. Anxiety, depression, and irritability in children with autism relative to other neuropsychiatric disorders and typical development. Research into Autism Spectrum Disorders; 5:474-485; 2011. Slide 32 Tsakanikos et al. Psychopathology in Adults with Autism and Intellectual Disability. Journal of Autism and Developmental Disorders; 36:1123-1129; 2006. Slide 33:

• Munir. The co-occurrence of mental disorders in children and adolescents with intellectual

disability/intellectual developmental disorder. Current Opinion in Psychiatry; 29:95-102; 2016. Slide 35: Rush et al. Assessing Psychopathology in Individuals with Developmental Disabilities. Behavior Modification; 28(5):621-637; 2004. Slide 36, 36 & 38: Martorell et al. Mental Health in Adults with Mild and Moderate Intellectual Disabilities. The Role of Recent Life Events and Traumatic Experiences Across the Life Span. J Nerv Ment Dis; 197:182-186; 2009.

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Slide 44: Kwok & Cheung. Comorbidity of Psychiatric Disorder and Medical Illness in People with Intellectual

• Disabilities. Current Opinion in Psychiatry; 20:443-449; 2007.

Slide 45 & 46: Ji & Findling. An update on pharmacology for autism spectrum disorder in children and adolescents. Current Opinion in Psychiatry; 28:91-101; 2015. Bent & Hendren. Complementary and Alternative Treatments for Autism Part 1: Evidence Supported

• Treatments. AMA Journal of Ethics; 17(4):369-274; 2015.

Slide 47, 48, 49 & 50: Ji & Findling. An update on pharmacology for autism spectrum disorder in children and adolescents. Current Opinion in Psychiatry; 28:91-101; 2015. Slide 51, 52, 53 & 54: Blackmer & Feinstein. Management of Sleep Disorders in Children With Neurodevelopmental Disorders: A Review. Pharmacotherapy; 36(1):84-98; 2016. Slide 55: Miano & Ferri. Epidemiology and Management of Insomnia in Children with Autistic Spectrum Disorders. Pediatr Drugs; 12(2):75-84; 2010. Slide 58: Ji & Findling. An update on pharmacology for autism spectrum disorder in children and adolescents. Current Opinion in Psychiatry; 28:91-101; 2015. Tryer P et al. Risperidone, haloperidol and placebo in the treatment of aggressive challenging behavior in adults with intellectual disability: a randomized controlled trial. The Lancet; 371:57-63; 2008. Turgay et al. Long-Term Safety and Efficacy of Risperidone for the Treatment of Disruptive Behavior Disorders in Children With Subaverage IQs. Pediatrics; 110(3); 2002.

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Slide 59: Ji & Findling. An update on pharmacology for autism spectrum disorder in children and adolescents. Current Opinion in Psychiatry; 28:91-101; 2015. Slide 60: Ji & Findling. An update on pharmacology for autism spectrum disorder in children and adolescents. Current Opinion in Psychiatry; 28:91-101; 2015. Slide 61:

Ji & Findling. An update on pharmacology for autism spectrum disorder in children and adolescents. Current Opinion in Psychiatry; 28:91-101; 2015. Tryer P et al. Risperidone, haloperidol and placebo in the treatment of aggressive challenging behavior in adults with intellectual disability: a randomized controlled trial. The Lancet; 371:57-63; 2008. Slide 62: Ji & Findling. An update on pharmacology for autism spectrum disorder in children and adolescents. Current Opinion in Psychiatry; 28:91-101; 2015. Slide 63: Dominick et al. A Retrospective Naturalistic Study of Ziprasidone for Irritability in Youth with Autism Spectrum Disorder. Journal of Child and Adolescent Psychopharmacology; 25(5); 2015. Malone et al. Ziprasidone in adolescents with autism: An open-label pilot study. J Child Adolesc Psychopharmacol; 17:779-790; 2007. Cohen et al. The effect of a switch to ziprasidone in an adult population with autistic disorder: Chart review of naturalistic, open-label treatment. J Clin Psychiatry; 65:110-113; 2004. Slide 64: Singh et al. The use of clozapine among individuals with intellectual disability: A review. Research in Developmental Disabilities; 31:1135-1141; 2010.

7 | P a g e Slide 65: Ji & Findling. An update on pharmacology for autism spectrum disorder in children and adolescents. Current Opinion in Psychiatry; 28:91-101; 2015. Aman et al. Methylphenidate treatment in children with borderline IQ and mental retardation: Analysis

• f three aggregated studies. Journal of Child and Adolescent Psychopharmacology; 13:29-40; 2003.

Slide 66: Ji & Findling. An update on pharmacology for autism spectrum disorder in children and adolescents. Current Opinion in Psychiatry; 28:91-101; 2015. Slide 67: Ji & Findling. An update on pharmacology for autism spectrum disorder in children and adolescents. Current Opinion in Psychiatry; 28:91-101; 2015. Slide 68: Ji & Findling. An update on pharmacology for autism spectrum disorder in children and adolescents. Current Opinion in Psychiatry; 28:91-101; 2015. Aman et al. Review of serotonergic agents and perseverative behavior in patients with developmental

• disabilities. Mental Retardation Developmental Disabilities Research Reviews; 5:279-289; 1999.

Slide 69: Verhoeven et al. Citalopram in mentally retarded patients with depression: A long-term clinical

• investigation. European Psychiatry; 16:104-108; 2001.

Ulzen & Hughes. SSRI switch rates to hypomania in an MR/MI outpatient population. Poster presentation at NADD conference, Denver, CO, 2002, In NADD Bulletin; 6(1); 2003.

8 | P a g e Slide 70: Ji & Findling. An update on pharmacology for autism spectrum disorder in children and adolescents. Current Opinion in Psychiatry; 28:91-101; 2015. Gordon et al, A Double-Blind Comparison of Clomipramine, Desipramine, and Placebo in the Treatment

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Slide 71: Ulzen & Powers. A Review of Empirical Evidence of Somatic Treatment Options for the MI/DD

• Population. Psychiatry Q; 79:265-273; 2008.

Craft et al. Lithium in the treatment of aggression in mentally handicapped patients: A double blind trial. British Journal of Psychiatry; 150:685-689; 1987. Tyrer et al. Effect of Lithium on Behavioral Factors in Aggressive Mentally Handicapped Subjects in Lithium in Medicine and Biology. Carnforth, Marius Press, 1993. Siegel et al. Preliminary Investigation of Lithium for Mood Disorder Symptoms in Children and Adolescents with Autism Spectrum Disorder. Journal of Child and Adolescent Psychopharmacology; 24(7); 2014. Slide 72: Ji & Findling. An update on pharmacology for autism spectrum disorder in children and adolescents. Current Opinion in Psychiatry; 28:91-101; 2015. Ulzen & Powers. A Review of Empirical Evidence of Somatic Treatment Options for the MI/DD

• Population. Psychiatry Q; 79:265-273; 2008.

Lindenmayer & Kotsaftis: Use of sodium valproate in violent and aggressive behaviors: A critical review. Journal of Clinical Psychiatry; 61:123-128; 2000. Slide 73, 74, 75, 76 & 77: Ji & Findling. An update on pharmacology for autism spectrum disorder in children and adolescents. Current Opinion in Psychiatry; 28:91-101; 2015.

9 | P a g e Slide 78: Ulzen & Powers. A Review of Empirical Evidence of Somatic Treatment Options for the MI/DD

• Population. Psychiatry Q; 79:265-273; 2008.

Kessler RJ. Electroconvulsive therapy for affective disorders in persons with mental retardation. Psychiatric Quarterly; 75(1):99-104; 2004.