Dr. Nora Khaldi Founder and Chief Scientific Officer @NuritasResearch
Evolution of Nuritas - Multi- discipline. - SFI funded PhD in Ireland and USA. € Marie Curie Mathematics & FP7 EU grant life-Science EI investment in US and industry industry academia interaction partnership I always thought big
Pioneering a step-change in peptide discovery Traditional discovery methods The Nuritas Way Time consuming Unrivalled speed 10 YEARS 10X FASTER* PREDICT More accurate Inefficient TARGET UNLOCK 500X MORE* < 0.1% CHANCE Incredibly expensive Cost efficient € €35+ MILLION LESS EXPENSIVE* Efficiency improving consistently * nuritas.com
Using AI to Unlock and Crack Natures Code for Health 30 billion peptides in one food source
Uniqueness of Nuritas – Speed, Accuracy & Efficiency Dis Discovery & valid idation Pep eptid tide Effic ficacy: Metaboli lic He Health th for orms th the e core e of of every ery Nuritas proje ject Type pe II Nur uritas Pe Pepti tides Diabe iabetes Re Reduce ce HbA HbA1c by 2.5% in by n 6 weeks In vivo vo Efficacy Day y 0 0 Cont ntrol KK KKAY Liver er 10µM/K /Kg g Peptide Treatment NASH NAS Nur uritas Pe Pepti tides (Fa Fatty Li Liver) Re Reduce ce Ste teatosis 9% 9% Reductio tion Cont ntrol KK KKAY Liver er 50µM/K /Kg g Peptide in n Wrin inkle le In vivo vo Depth Efficacy Bioac Bi oactive Peptide ides & Treatment Peptid ide Ne Networks * TNF α Secretion * 10 1000 00s of Peptid ides 1.0 Pred redic icted pe per r Hea Healt lth 0 Inf nflammation Area ea -1.0 Placebo Peptide -2.0 Network Human clinical TARGET PRE PREDICT CT UNLOCK UN -3.0 6 Months V2 V3 V4 3 3 Months 1 Month 1 6 6 Months 3 3 Months
Peptide Portfolio Predicted Produced In-Vitro Testing Scaling Pre-Clinical Entering Clinical In Clinical On Market / Market Ready Anti-inflammatory PeptAIde Pre-Diabetes PeptiForce Diabetes Muscle atrophy PeptiStrong Cardiovascular Preservation Aging Lorvia NASH Gut Microbiome Treatment Undruggable Preventio ion Targets 6 nuritas.com
Evolution of Nuritas - Multi- discipline. 2017 2015 - SFI funded PhD in Ireland and USA. 2015 1 st in-vivo success Collaboration with BASF through 3 rd party 1 st human clinical success € € € € People EIB Nuritas Marie Curie Series A Seed €5M Mathematics & - Nuritas team Investment FP7 EU grant birth €20M Singapore life-Science €30M 2014 USA EI investment in US and Communication industry Small 100k Launch of industry Fully integrated Series B with the academia grant Peptaide interaction lab and AI EU? world partnership Improving the € lives of billions 2018 2016 2014 I always thought big
Why is European Innovation lagging behind the US? nuritas.com
Innovation is in our genes John Logie Baird Casimir Zeglen Karl Elsener Marie Curie Kálmán Tihanyi Television 1925 Bullet proof vest Swiss Army Knife 1891 Radioactivity Thermographic camera 1893 1929 Alan Turing Tim Berners-Lee Seppo Säynäjäkangas Otto Wichterle Modern Computer World Wide Web Heart Rate Monitor Soft Contact Lenses 1936 1989 1977 1961
It is not the strongest of the species that survives, nor the most intelligent that survives. It is the one that is most adaptable to change . Charles Darwin (1809-1882) nuritas.com
An ecosystem • The ecosystem of fostering unicorns is missing. • Innovative companies migrate toward innovative cradles of support. • Spot the potential unicorns early => Use local agencies. • Make it hard for outside EU funding. • Help potential unicorns to scale e.g. easier grants for unicorns. • Make it easy for them to succeed. • Teach our kids early that it’s ok to take a year out to innovate. nuritas.com
Our Mission Improving the lives of billions of people worldwide through the predicted discovery of Bioactive Peptides nuritas.com
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