Dr. Nora Khaldi Founder and Chief Scientific Officer - - PowerPoint PPT Presentation

• Dr. Nora Khaldi

Founder and Chief Scientific Officer

@NuritasResearch

Evolution of Nuritas

Mathematics & life-Science Marie Curie FP7 EU grant US and industry interaction I always thought big EI investment in industry academia partnership

• Multi- discipline.
• SFI funded PhD in

Ireland and USA.

€

Traditional discovery methods

Time consuming

10 YEARS

Incredibly expensive

€35+ MILLION

Inefficient

< 0.1% CHANCE

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Pioneering a step-change in peptide discovery

The Nuritas Way

More accurate

500X MORE*

Unrivalled speed

10X FASTER*

Cost efficient

LESS EXPENSIVE*

€

PREDICT TARGET UNLOCK

Efficiency improving consistently*

Using AI to Unlock and Crack Natures Code for Health

30 billion peptides in one food source

Uniqueness of Nuritas – Speed, Accuracy & Efficiency

3 3 Months

6 Months

6 6 Months 3 3 Months 1 1 Month

TARGET PRE PREDICT CT UN UNLOCK

Dis Discovery & valid idation for

• rms th

the e core e of

• f every

ery Nuritas proje ject

Day y 0 Treatment 9% 9% Reductio tion in n Wrin inkle le Depth Treatment

Cont ntrol KK KKAY Liver er Cont ntrol KK KKAY Liver er 10µM/K /Kg g Peptide 50µM/K /Kg g Peptide

Nur uritas Pe Pepti tides Re Reduce ce Ste teatosis

Bi Bioac

• active Peptide

ides & Peptid ide Ne Networks

10 1000 00s of Peptid ides Pred redic icted pe per r Hea Healt lth Area ea

Pep eptid tide Effic ficacy: Metaboli lic He Health th

In vivo vo Efficacy Human clinical

Type pe II Diabe iabetes

Nur uritas Pe Pepti tides Re Reduce ce HbA HbA1c by by 2.5% in n 6 weeks

NAS NASH

(Fa Fatty Li Liver)

In vivo vo Efficacy Inf nflammation

Placebo Peptide Network

1.0

• 1.0
• 2.0
• 3.0

TNFα Secretion

* *

V2 V3 V4

nuritas.com 6

Peptide Portfolio

Predicted Produced In-Vitro Testing Scaling Pre-Clinical Entering Clinical In Clinical On Market / Market Ready Anti-inflammatory Pre-Diabetes Diabetes Muscle atrophy Cardiovascular Preservation Aging NASH Gut Microbiome Undruggable Targets

Treatment Preventio ion

PeptiStrong PeptiForce PeptAIde Lorvia

Evolution of Nuritas

Mathematics & life-Science Marie Curie FP7 EU grant US and industry interaction EI investment in industry academia partnership

• Multi- discipline.
• SFI funded PhD in

Ireland and USA.

€

Nuritas birth 2014 Small 100k grant Seed €5M Singapore 2015 1st in-vivo success through 3rd party

2015

Communication with the world

€

People

• Nuritas team

€

Collaboration with BASF 1st human clinical success Fully integrated lab and AI

2016 2017

Series A €20M USA Launch of Peptaide

€ 2018 €

EIB Investment €30M Series B EU? Improving the lives of billions I always thought big

2014

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Why is European Innovation lagging behind the US?

Innovation is in our genes

Marie Curie Radioactivity Karl Elsener Swiss Army Knife 1891 Casimir Zeglen Bullet proof vest 1893 Kálmán Tihanyi Thermographic camera 1929 Seppo Säynäjäkangas Heart Rate Monitor 1977 Alan Turing Modern Computer 1936 Otto Wichterle Soft Contact Lenses 1961 Tim Berners-Lee World Wide Web 1989 John Logie Baird Television 1925

It is not the strongest of the species that survives, nor the most intelligent that survives. It is the one that is most adaptable to change.

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Charles Darwin (1809-1882)

An ecosystem

• The ecosystem of fostering unicorns is missing.
• Innovative companies migrate toward innovative cradles of support.
• Spot the potential unicorns early => Use local agencies.
• Make it hard for outside EU funding.
• Help potential unicorns to scale e.g. easier grants for unicorns.
• Make it easy for them to succeed.
• Teach our kids early that it’s ok to take a year out to innovate.

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Our Mission

Improving the lives of billions of people worldwide through the predicted discovery of Bioactive Peptides

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