DNA FUNCTIONS TOMORROWS NEW HOPE AGAINST RESISTANT CANCER LISTED - - PowerPoint PPT Presentation

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DNA FUNCTIONS TOMORROWS NEW HOPE AGAINST RESISTANT CANCER LISTED - - PowerPoint PPT Presentation

TODAYS SCIENCE TARGETING TUMOR DNA FUNCTIONS TOMORROWS NEW HOPE AGAINST RESISTANT CANCER LISTED EURONEXT Paris NASDAQ Copenhagen EPA: ONXEO Important Information IMPORTANT: You must read the following before continuing. In


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LISTED

EURONEXT │ Paris NASDAQ │ Copenhagen EPA: ONXEO

TODAY’S SCIENCE TARGETING TUMOR DNA FUNCTIONS TOMORROW’S NEW HOPE AGAINST RESISTANT CANCER

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June 2020 IMPORTANT: You must read the following before continuing. In accessing this document, you agree to be bound by the following terms and conditions. This document has been prepared by Onxeo SA (together with its subsidiaries, the "Group") and is for information purposes only. The content of this document is provisional and for information purposes only and is not to be construed as providing investment advice. The information, statements and opinions contained in this document (the “Information”) are provided as of the date of this document only and June be subject to significant changes at any time without notice. Neither the Group, nor its advisors, nor any other person is under any obligation to update the Information. Subject to applicable law, none of the Company or its advisors accepts any responsibility whatsoever and makes no representation or warranty, express or implied, as to the fairness, accuracy, completeness or correctness of the Information. The Information has not been subject to independent verification and is qualified in its entirety by the business, financial and other information that the Group is required to publish in accordance with the rules, regulations and practices applicable to companies listed on Euronext Paris, including in particular the risk factors described in in the most recent Company’s Universal Registration Document filed with the French Financial Markets Authority (Autorité des marchés financiers), in any other periodic report and in any other press release, which are available free of charge on the websites of the Group (www.onxeo.com) and/or the AMF (www.amf-france.org). This document contains information on the use of the Group's products and its competitive position. Some of the Information is from third parties. While this third party information has been obtained from sources believed to be reliable, there is no guarantee of the accuracy or completeness of such data. In addition, certain of the industry and market data comes from the Group's own internal research and estimates based on the knowledge and experience of the Group's management. While the Group believes that such research and estimates are reasonable and reliable, they, and their underlying methodology and assumptions, have not been verified by any independent source for accuracy or completeness and are subject to change without notice. Accordingly, undue reliance should not be placed on any of the industry, market or competitive position data contained in the Information. The Information is not directed to, or intended for distribution to or use by, any person or entity that is a citizen or resident of, or located in, any locality, state, country or other jurisdiction where such distribution or use would be contrary to law or regulation or which would require any registration or licensing within such jurisdiction. The Information does not constitute or form part of, and should not be construed as an offer or the solicitation of an offer to subscribe for or purchase of any securities. No public offering of securities June be conducted in France prior to the delivery by the French Financial Markets Authority of a visa on a prospectus that complies with the provisions of Directive 2003/71/CE as amended. This document is for information purposes only and does not constitute an offering document or an offer of securities to the public in the United Kingdom to which section 85 of the Financial Services and Markets Act 2000 of the United Kingdom applies. Securities June not be offered or sold in the United States absent registration under the US Securities Act of 1933, as amended, or an exemption from registration thereunder. This document contains certain forward-looking statements. All statements in this document other than statements of historical fact are or June be deemed to be forward looking statements. These statements are not guarantees of the Group's future performance. These forward-looking statements relate without limitation to the Group's future prospects, developments, marketing strategy regulatory calendar, clinical milestones, assumptions and hypothesis, clinical development approach and financial requirements and are based on analyses of earnings forecasts and estimates of amounts not yet determinable and other financial and non- financial information. Forward-looking statements are subject to a variety of risks and uncertainties as they relate to future events and are dependent on circumstances that June or June not materialize in the future. Forward-looking statements cannot, under any circumstance, be construed as a guarantee of the Group's future performance as to strategic, regulatory, financial or other matters, and the Group’s actual performance, including its financial position, results and cash flow, as well as the trends in the sector in which the Group operates, June differ materially from those proposed or reflected in the forward-looking statements contained in this document. Even if the Group’s performance, including its financial position, results, cash-flows and developments in the sector in which the Group operates were to conform to the forward-looking statements contained in this document, such results or developments cannot be construed as a reliable indication of the Group's future results or developments. The Group expressly declines any obligation to update or to confirm projections or estimates made by analysts or to make public any correction to any prospective information in order to reflect an event or circumstance that June occur after the date of this document.

Important Information

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June 2020

Developing disruptive therapies in the field of DNA Damage Response (DDR) to address unmet needs in oncology

3

NEXT KEY MILESTONES FUNDED

Financial visibility to Q1 2022 supports strategic plan to deliver key near-term clinical milestones

STRONG MANAGEMENT & OPERATIONAL TEAM

A highly skilled team of 30, with strong translational & clinical expertise, led by experienced management and board of directors with demonstrated track record in product & business development

DIFFERENTIATED SCIENCE IN DNA DAMAGE RESPONSE

PlatON™, proprietary chemistry platform of decoy

  • ligonucleotides, generating new compounds

AsiDNA™, lead candidate at clinical stage, a first-in-class decoy agonist showing unique anti-tumoral properties OX401, a newly optimized next-gen PARPi*

A WELL-DEFINED BUSINESS MODEL

Create value by bringing drug candidates from preclinical stage to proof-of concept in man, the best inflection points to monetize these assets and generate revenues.

LISTED

EURONEXT │ Paris NASDAQ │ Copenhagen EPA: ONXEO

* PARP inhibitors (PARPi) are a leading class of targeted therapies, the first approved and marketed in the field of DDR

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June 2020

FRANCOISE BONO (PHD) CSO (Sanofi, Evotec) Formerly Executive Vice-President Oncology

  • f Evotec

Experienced management team with demonstrated track record in product & business development

4

JUDITH GRECIET (PHARM.D) CEO OLIVIER DE BEAUMONT (MD) CMO (Aventis, Quintiles, Stallergenes Greer) Formerly Senior Vice President, Head of Global Clinical Development, Pharmacovigilance and Medical Affairs ofStallergenes Greer PHILIPPE MAITRE EVP of Onxeo US, CBDO (Aventis, PPD, Oscient, mAbRx) Formerly Chief Executive Officer and Co- Founder of mAbRx NICOLAS FELLMANN CFO (Ernst & Young, Pfizer) Formerly Director of Treasury, Tax & Audit of Pfizer France (Pharmacia, Wyeth (Pfizer), Eisai) Formerly President of Eisai France

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June 2020

Current cutting-edge R&D pipeline with unique mechanisms of action in DDR

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Programs

OPTIMIZATION PRECLINICAL PHASE I PHASE Ib PHASE II

platON™ Proprietary Platform of Decoy Oligonucleotides OX401

Next-gen PARPi + STING pathway activation

AsiDNA™ intratumoral AsiDNA™ + chemotherapy Synergistic efficacy AsiDNA™ + PARPi Resistance abrogation AsiDNA™ + other targeted tx Resistance abrogation/ prevention

DRIIV -1b

DRIIV study in solid tumors

GENERATION OF NEW COMPOUNDS TARGETING DNA FUNCTIONS

DNA Damage Response

Ongoing proof-of concept Ongoing proof-of concept

DDR + IO

REVocan

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AsiDNA™

Unique Decoy Agonist Mechanism of Action in DNA Damage Response

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June 2020

AsiDNA™: a differentiated product in the clinically-validated field of DDR

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Source : Quanz M, et al. Clin Cancer Res 2009 15:1308-1316; Quanz M, et al. PLoS ONE. 2009 4(7), doi: 10.1371/ journal.pone. 0006298; Jdey W, et al. Clin Can Res. 2016;22:DOI: 10.1158/ 1078-0432.CCR-16-1193 * PARP inhibitors (PARPi) are a leading class of targeted therapies, the first approved and marketed in the field of DDR

DDR inhibition is clinically-validated in oncology (PARPi*) Decoy-agonist mode of action avoids compensatory mechanisms, blocking the induction of resistance AsiDNA™ acts upstream of the DDR, enabling cytotoxic activity regardless of genetic context Cytotoxic activity is restricted to cancer cells, translating into an outstanding safety profile AsiDNA™ is a decoy agonist oligonucleotide that mimics DNA breaks in the tumor cell (decoy), binds and hyperactivates the proteins (agonist) involved in the DDR cascade (sensing, signaling and repairing) … … diverts them away from the true damage …., … leading to cellular death.

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June 2020

AsiDNA™ is a first-in-class therapy for combination designed to address the #1 challenge in oncology: resistance to treatment

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Decoy Agonist MoA does not induce resistance Differentiated Decoy Agonist MoA in the clinically-validated field

  • f DNA Damage Response

Long IP (up to 2040) Clinical-stage asset

Favorable safety profile incl. in combination Proof of mechanism / signals of efficacy

Strategic focus on the abrogation of resistance to targeted therapies

Collaborations with top-academic centers

(Institut Curie - Gustave Roussy – Oncopole Toulouse…)

REVocan Phase 1b/2 to evaluate the addition of AsiDNA™ on the abrogation resistance to niraparib (to start Q3 2020) Depletes the cells from which resistance to targeted therapies emerge

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June 2020

20 40 60 2×104 4×104 6×104 8×104 1×105 1×106 2×106 3×106 4×106 5×106 6×106

Nira Nira+Asi continuous Nira+Asi at D34 Days post treatment Cell number

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UWB1.289 (Ovarian Cancer model – BRCA1-/-)

AsiDNA™ abrogates acquired resistance to PARP inhibitors (class effect)

AsiDNA™ leads to niraparib-resistant cells eradication in ovarian cancer model, even if introduced only

  • nce resistance emerges (CA 125 increase)

REVocan study (REVersion of resistance in Ovarian Cancer with AsiDNA™ and Niraparib) was designed

  • n the basis of these results

D17 D24 D31 D40 D17 D24 D31 D40 5 10 15 20 30 60 90 120 150

CA125 (pg/ml)

Introduction at CA125 increase (REVocan study protocol) Start of AsiDNA™ administration

Source: Onxeo, data on file

niraparib Emergence of Resistant cells Cell death Start of AsiDNA™ administration (D34)

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June 2020

Results confirmed in in vivo experiments in a triple negative breast cancer model

AsiDNA™ abrogates acquired resistance to PARP inhibitors

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MDAMB-436 (TNBC HR deficient - PARPi sensitive)

Source: Onxeo, data on file

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June 2020

Non Small Cell Lung Cancer model – anti-EGFR sensitive

AsiDNA™ eradicates cells resistant to anti-EGFR and anti-ALK

AsiDNA™ prevents resistance to other targeted tx such as TKI

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3 5 6 7 10 12 13 14 17 21 24 27 34 38 41 46 49 52

  • 20

20 40 60 80 100 120

Erlotinib Erlotinib+AsiDNA

Time (days) Surviving cells (%)

No surviving cells Emergence of resistant cells No surviving cells Emergence of resistant cells

PC9-3 (NSCLC EGFRmut) - EGFR T790 mutation is preexisting in PC9 parental cell line. PC9-3 cell line is a sub-clone of PC9 without preexisting T790M.

Non Small Cell Lung Cancer model – anti-ALK sensitive

H3122 (NSCLC EML4-ALK)

Source: Onxeo, data on file

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AsiDNA™

Clinical Development Plan Validation of the Effect of AsiDNA™ on Resistance to Targeted Therapies

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June 2020

Delivering the promises of AsiDNA™ to patients

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DRIIV-1 Phase 1 First IV administration in solid tumors

 Favorable safety via I.V.  Proof of mechanism in tumors

DRIIV-1b Phase 1b (IV) Combo with carboplatin +/- paclitaxel (ongoing)

 Excellent safety in combination with chemotherapy  Prelim. signals of efficacy

Cohort 2 (Carboplatin + Paclitaxel) ongoing

REVOCAN Phase 1b/2 (IV) Ovarian cancer in combination w/ PARPi niraparib Proof of Concept: Abrogation of resistance to PARPi FPI expected Q3 2020 Phase 1b/2 (IV) Non small cell lung cancer in combination w/ other targeted therapies (TKI, KRAS,…) Proof of Concept: Prevention/Abrogation of resistance to targeted therapies

SHORT/MID -TERM ONGOING COMPLETED

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June 2020

DRIIV-1 Phase 1: Favorable safety profile & demonstrated proof-of- mechanism

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Phase I study in I.V.

Open-label, 3+3 dose escalation from 200mg to 1800mg 22 patients; 5 doses Study coordinator: Pr. C. Le Tourneau (Institut Curie) Objectives: to determine the safety and PK/PD profile of AsiDNA™

Primary objective reached: favorable safety outcome

AsiDNA™ 200mg, 400mg, 600mg: No drug-related Serious Adverse Events (SAEs) and no Dose-Limiting Toxicity (DLT) AsiDNA™ 900mg & 1300mg: 3 related SAEs, including 2 DLTs per dose MTD was not reached

DRIIV-1 results were presented at EORTC-NCI-AACR on 10/27/19

181 (89%) 22 (11%) 1

Grade 1/2 Grade 3 Non-related 95%

Non-related 77% Adverse Events

Proof-of-mechanism : Strong activation of γH2AX at cell level, reflecting DNA-PK pathway engagement

Activity, pharmacodynamic biomarkers (on tumor biopsies)

Pre-treatment Post-treatment

γH2AX: Readout of DNA-PK target engagement

Patient 003-001

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June 2020

DRIIV-1b Phase 1b: Preliminary data confirm safety and efficacy signals

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AsiDNA™ 600 mg

Cohort 1

carboplatin AsiDNA™ 600 mg carboplatin + paclitaxel

Cohort 2

6 pts

  • ngoing

+ +

Patients with ≥ 3 prior lines of treatment, progressing at inclusion Very good tolerance of the combination (no DLT) Disease stabilized (SD) in 2/3 patients for 5.5 mo. (TNBC 6th L) and 10 mo. (NSCLC 3rd L) Disease controlled with AsiDNA™ for significantly longer than with any of the prior treatment lines

3 pts

Topline results expected end 2020 *

* Timelines include Covid-19 impact to date, and may be further reviewed

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June 2020

Phase Ib/II study: Proof-of-concept of the abrogation of resistance to PARP inhibitors by AsiDNA™

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Patients selection: patients under 2nd line of maintenance with niraparib > 6 months Inclusion at CA 125 increase (CA 125 : well established predictive biomarker of resistance in OC) n= up to 26 patients, platinum-sensitive relapsed ovarian cancer Primary objective: Safety run & CA125 decrease (GCIG criteria) Secondary objective: Efficacy: PFS (RECIST criteria) - OS

REVocan

REVersion of resistance in Ovarian Cancer with AsiDNA™ and Niraparib Study approved by regulatory authorities late May 2020 FPI expected from H2 2020 => Preliminary data by end 2020/early 2021 *

PI: Dr. Patricia Pautier (Arcagy Gineco Network)

Clinical collaboration

N = up to 26 pts & 6 centers

* Timelines include Covid-19 impact to date, and may be further reviewed

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June 2020

Our strategic priority: validate the potential of AsiDNA™ in combination in various types of key indications

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Preventing resistance – a major challenge for targeted therapies such as PARPis & TKIs - would lead to prolonged efficacy

❶ ❷

“Resistance is the biggest challenge in cancer biology” (Paul Workman – ICR)

Strategic objectives Targeted Indications Opportunity Approval / Full Market Size

Optimal market access (fast, favorable P&R*)

2L with niraparib (PARPi) in ovarian cancer Short endpoint: PFS Expansion of maintenance treatment and delay new course of platinum

2025/26 $6,7B (1) Access large WW markets

E.g. 1L with TKI or other targeted tx in non-small cell lung cancer Target specific population with high risk of progression e.g. $16,9B (1) for 1L NSCLC

REVocan Combo w/ PARPi Combo w/ other targeted therapies

* P&R : pricing & reimbursement - (1) GlobalData (8MM)

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Financials & Outlook

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June 2020

Financial resources in line with key development milestones objectives

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Financière de la Montagne 13% Invus 11% Free float 76%

Cash position of €7.3m at 03/31/2020

+ €6m from transaction with Acrotech on 04/06/2020 + €7.3m from private placement on 06/09/2020 to Invus, new long-term

shareholder, & Financière de la Montagne, historical shareholder Cash runway to Q1 2022

Shares outstanding

78.3m

Average Daily Volume

555,980 shares

Dual listing Euronext Paris & Nasdaq Copenhagen

ISIN: FR0010095596

At 06/11/2020 YTD at 06/12/2020

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SLIDE 20

June 2020

Short-term key clinical catalysts in 2020/early 21, with moderate impact of Covid-19 on milestones to date

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DRIIV-1b cohort 2 Topline data

H2 2019 H1 2020 * H2 2020 *

DRIIV-1b cohort 1

  • prelim. data

REVOCAN First data set DRIIV-1b cohort 2 Preliminary data

AsiDNA™ +Tx

data to support clinical plan

AsiDNA™ +Tx

Data to support clinical plan Preclinical validation of OX401 profile

Tolerance in combination + first signals of efficacy

DRIIV–1b

AsiDNA™ + carboplatin +/- paclitaxel

REVOCAN phase 1b/2

AsiDNA™ + niraparib

Clinical Research agreement

Reversion of Resistance Prevention of resistance

AsiDNA™ + TKI/KRAS/…

Preclinical proof-of-concept

Next-gen PARPi + activation of immune response

OX401

Preclinical proof of mechanism

* *

* Timelines include Covid-19 impact to date, and may be further reviewed

FPI

*

Reg. approvals

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June 2020

Onxeo 2020: Ready for success

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Broad development and commercial potential in multiple indications with high unmet needs AsiDNA™, innovative product at clinical stage, with confirmed activity in man and favorable safety profile including in combination. 2nd phase 1b/2 study REVocan initiated to demonstrate unique ability to fight tumor acquired resistance to PARPi and to deliver data in the short term platON™ platform to generate promising compounds based on unique decoy agonist mechanism of action AsiDNA™, first-in-class DDR inhibitor, the only decoy agonist in the DDR field, with a robust preclinical package supporting a broad range of potential indications/combinations Profile of next candidate from platON™ to be announced mid 2020, positioning Onxeo at the cross road of DDR (PARP inhibition) and immuno-oncology (STING pathway)

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Publications

Back-up slides

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June 2020

AsiDNA™ Publications (1/2)

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Hyperactivation of DNA-PK by double-strand break mimicking molecules disorganizes DNA damage response. Quanz M et al. PLoS One. 2009, 4:e6298. Histone γH2AX and Poly(ADP-Ribose) as Clinical Pharmacodynamic Biomarkers, Redon CE et al. Clin Cancer Res 2010; 16(18) Comparison of distribution and activity of nanoparticles with short interfering DNA (Dbait) in various living systems. Berthault N. et al. Cancer Gene Ther. 2011, 18:695-706. Heat shock protein 90 (Hsp90) is phosphorylated in response to DNA damage and accumulates in repair foci. Quanz M. et al. J Biol. Chem. 2012, 287:8803-15. Preclinical study of the DNA repair inhibitor Dbait in combination with chemotherapy in colorectal cancer. Devun F et al. J Gastroenterol. 2012, 47:266-75. Pharmacokinetics and toxicity in rats and monkeys of coDbait: a therapeutic double-stranded DNA oligonucleotide conjugated to cholesterol. Schlegel A et al. Mol Ther Nucleic Acids. 2012, 1:e33. Distribution and radiosensitizing effect of cholesterol-coupled Dbait molecule in rat model of 5 glioblastoma. Coquery N et al. PLoS One. 2012;7(7):e40567. Resistance to PARP-Inhibitors in Cancer Therapy. Montoni A et al. Front Pharmacol. 2013; 4: 18. Kinesin KIFC1 actively transports bare double-stranded DNA. Farina F et al. Nucleic Acids Res. 2013, 41:4926-37. Inhibition of DNA damage repair by artificial activation of PARP with siDNA. Croset A et al. Nucleic Acids Res. 2013, 41:7344-55. DNA-PK target identification reveals novel links between DNA repair signaling and cytoskeletal regulation. Kotula E et al. PLoS One, 2013: 8(11):e80313. Colorectal cancer metastasis: the DNA repair inhibitor Dbait increases sensitivity to hyperthermia and improves efficacy of radiofrequency ablation. Devun F et al. Radiology. 2014, 270:736-46. A preclinical study combining the DNA repair inhibitor Dbait with radiotherapy for the treatment of melanoma. Biau J et al. Neoplasia. 2014, 16:835-44. An update on PARP inhibitors for the treatment of cancer. Benefif S et al. Dbait: An innovative concept to inhibit DNA repair and treat cancer. Biau J et al. Bull Cancer 2016; 103: 227–235 The DNA Repair Inhibitor DT01 as a Novel Therapeutic Strategy for Chemosensitization of Colorectal Liver Metastasis. Herath NI et al. Mol Cancer Ther. 2016 Jan;15(1):15-22. Targeting DNA Repair in Cancer: Beyond PARP Inhibitors, Brown JS et al. Cancer Discov December 21 2016 DOI: 10.1158/2159-8290.CD-16-0860 Targeting DNA repair by coDbait enhances melanoma targeted radionuclide therapy. Viallard C et al. Oncotarget 2016 Mar 15;7(11): 12927-36. First-in-human phase I study of the DNA repair inhibitor DT01 in combination with radiotherapy in patients in with skin metastases from melanoma. Le Tourneau C et al. Br J Cancer. 2016 June 24;114(11):1199-205. Potentiation of Doxurubicin efficacy in hepatocellular carcinoma by the DNA repair inhibitor DT01 in preclinical models. Herath NI et al. Eur Radiol. 2017 Oct, 27(10):4435-4444. Drug Driven Synthetic Lethality: bypassing tumor cell genetics with a combination of AsiDNA and PARP inhibitors. Jdey W et al. Clin Cancer Res. 2017 Feb 15;23(4):1001-1011 Micronuclei Frequency in Tumors Is a Predictive Biomarker for Genetic Instability and Sensitivity to the DNA Repair Inhibitor AsiDNA. Jdey W et al. Cancer Res. 2017 Aug 15;77(16):4207-4216.

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June 2020

AsiDNA™ Publications (2/2)

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The DNA Repair Inhibitor Dbait Is Specific for Malignant Hematologic Cells in Blood. Thierry S et al. Mol Cancer Ther. 2017 Dec;16(12):2817–27. Combining the DNA Repair Inhibitor Dbait With Radiotherapy for the Treatment of High Grade Glioma: Efficacy and Protein Biomarkers of Resistance in Preclinical Models. Biau J et al. Front

  • Oncol. 2019 Jun 19;9:549

Moving From Poly (ADP-Ribose) Polymerase Inhibition to Targeting DNA Repair and DNA Damage Response in Cancer Therapy. Gourley C et al. J Clin Oncol. 2019 June 3 AsiDNA™ treatment induces cumulative antitumor efficacy with a low probability of acquired resistance. Jdey W et al. Neoplasia (2019)21, 863–871 Preclinical studies comparing efficacy and toxicity of DNA repair inhibitors, olaparib and AsiDNA, in treatment of carboplatin resistant tumors. Jdey W et al. Front. Oncol., 12 November 2019 | https://doi.org/10.3389/fonc.2019.01097

Posters

AACR 2013 Preclinical study of Dbait, an inhibitor of three DNA repair pathways, in breast cancer treatment ASCO 2015 First-in-human phase I study of the DNA repair inhibitor DT01 in combination with radiotherapy in patients with skin metastases from melanoma AACR 2017 AsiDNA™ induces tumor sensitivity to PARP inhibitors in homologous recombination proficient breast cancer AACR 2018 AsiDNA™ and HDAC inhibitors: A cross-potentiation team work to kill tumor cells Evolution of tumor cells under Dbait (AsiDNA) treatment results in “autosensitization” AACR 2019 AsiDNA™ abrogates acquired resistance to PARP inhibitors Development of a Biomarker-driven patient selection strategy for AsiDNA™ treatment Molecular analysis of the mechanism of action of AsiDNA™ brings new clues on DNA damage response regulation AsiDNA™, a novel DNA repair inhibitor to radio-sensitize aggressive medulloblastoma subtypes EORTC-NCI-AACR 2019 Phase I dose escalation study evaluating the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of AsiDNA™, a first-in-class DNA Repair Inhibitor, administered intravenously (IV) in patients with advanced solid tumors AACR 2020 Virtual Meeting (Poster and audio online June 22-24, 2020) Acquired resistance to PARP inhibitors evolves from drug-tolerant persister cells vulnerable to AsiDNA™

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CONTACTS Judith Greciet – CEO Nicolas Fellmann – CFO Françoise Bono – CSO Olivier de Beaumont – CMO Tel: +33 1 45 58 76 00 COMPANY INFORMATION www.onxeo.com investors@onxeo.com