SLIDE 15 10/16/2015 15
Alcohol: Cohort Study
The Lifestyle During Pregnancy Study (LDPS): prospective cohort study, sampled from the larger Danish National Birth Cohort (>100,000)
- Of note: some alcohol consumption during pregnancy was
considered acceptable to Danish women at that time
- Design: recruited 1617 women, sampled to represent 20
different drinking patterns
– Phone interview at 12 & 30wk to ascertain weekly alcohol intake, and any binge (5+) drinking – Controlled for smoking, diet, SES, maternal IQ, medical &
– Assess cognitive, behavioral, emotional & social functions in children at age 5
Kesmodel US et al. Lifestyle during pregnancy: neurodevelopmental effects at 5 years of age. The design and implementation of a prospective follow-up study. Scand J Public Health 2010;38(2):208–19 Kesmodel U, Kesmodel PS. Drinking during pregnancy: attitudes and knowledge among pregnant Danish women, 1998
Alcohol: LDPS Results
All results are based on assessment
LDPS Results: Intelligence
Outcome measure: IQ assessed with the Wechsler Primary and Preschool Scales of Intelligence
- By average number of drinks per week:
– 1-4, or 5-8 drinks: no difference by any analysis
- Mean IQ of 106 or 104, versus 105 in nondrinkers
- No higher risk of low IQ (OR 0.9-1.1)
– 9+ drinks:
- Mean IQ of 99 (not statistically significant from 105)
- Higher risk of low IQ (OR 4.6)
- By binge drinking:
– no differences except that binge drinking at GA 1-2wk reduced risk of low IQ (OR 0.5)
Eriksen H, Mortensen, Kilburn, et al. The effects of low to moderate prenatal alcohol exposure in early pregnancy on IQ in 5-year-old
- children. BJOG 2012;119(10):1191–200.
Kesmodel, Eriksen H, Underbjerg, et al. The effect of alcohol binge drinking in early pregnancy on general intelligence in children. BJOG 2012;119(10):1222–31.
LDPS Results: Attention
Attention was measured using the recently developed Test of Everyday Attention for Children at Five Average attention score = 0, higher is better
- By average number of drinks per week:
– 1-4, or 5-8 drinks: no difference by any analysis
- Mean score difference: (+0.03 and +0.03)
- No higher risk of low score (OR 1.17, and 1.37)
– 9+ drinks:
- Mean score difference of -0.45 (-1.08, 0.18)
- Higher risk of low score, OR 3.2 (1.08, 9.53)
- By binge drinking:
– no differences on any measures
Eriksen H, Mortensen, Kilburn, et al. The effects of low to moderate prenatal alcohol exposure in early pregnancy on IQ in 5-year-old
- children. BJOG 2012;119(10):1191–200.
Kesmodel, Eriksen H, Underbjerg, et al. The effect of alcohol binge drinking in early pregnancy on general intelligence in children. BJOG 2012;119(10):1222–31.
