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B-CURE LASER IS AN EFFECTIVE, CLINICALLY PROVEN MEDICAL DEVICE, FOR TREATING PAIN AND ITS SOURCE AT HOME

ABOUT GOOD ENERGIES

KEY HIGHLIGHTS GOOD ENERGIES

MANAGEMENT +100 EMPLOYEES

Michael and Zipi Schlosser founded Erika Carmel Ltd. (B-Cure Laser) in 2008.

ERIKA CARMEL LTD. THE FOUNDERS

at our headquarters in Haifa and at our call center in Rishon LeZion, Israel an international distributing partner network for global access

THE COMPANY SUPPORTS

OUR VISION

To lead through the development and marketing of innovative and advanced therapeutic products in the fields of

• rthopedic conditions, pain, wounds

and dermatology. We strive to improve patient quality of life, by shortening the healing process and improve patient wellbeing.

OUR PROMISE

To spread Good Energies with the right partners around the world!

OUR INSPIRATION

The secret of change is to focus all

• f your energy not on fighting the
• ld, but on building the new
• Socrates

“ “

ABOUT B-CURE LASER

EFFECTIVE, CLINICALLY PROVEN AND SAFE treatment for pain, orthopedic conditions and wounds

OUR PRODUCTS

B-CURE LASER SERIES PROFESSIONAL AND HOME USE

THE ADJUSTABLE STAND

REACHING YOUR PAIN EVERYWHERE AND ANYWHERE! A flexible, adjustable stand enables convenient and effective treatment, without having to actually hold the B-Cure Laser with your hands.

HOW DOES THE B-CURE LASER WORK?

Stimulates cell activity & strengthens cell signals that relieve pain, fight chronic inflammation and accelerate wound healing Releases endorphins that relieve pain Increases the production of ATP that accelerates wound healing and fights chronic inflammation Stimulates blood and lymph flow that reduce edema and accelerate wound healing Increases the formation

• f collagen & elastin,

that accelerates wound healing Increases efficiency of the body’s natural immune system

B-CURE LASER ESSENTIAL IN EVERY HOME

ONE MEDICAL DEVICE THAT HELPS THE WHOLE FAMILY

MARKET OVERVIEW

PAIN AND WOUND MANAGEMENT GLOBAL MARKET Pain Relief

The global pain relief market is estimated to reach $79B revenue by 2024 (4% CAGR)

Wound Care

The global wound care market is estimated to reach $42B revenue by 2024 (6.2% CAGR)

$42B $79B

Dressings

Advanced dressings include silver dressings and combination dressings which consist of an anti-microbial agent.

Painkillers

Prescription of painkiller medication is one of the most popular ways to deal with pain. However, clinical research is raising public awareness to the severe related side effects.

Others

Physiotherapy, electrotherapy, shock wave therapy, acupuncture and

• ther forms of treatment, might add

extra discomfort to an already suffering patient. Requires patients to invest time and effort in traveling to specialized clinics.

PAIN AND WOUND MANAGEMENT TRADITIONAL CARE

A NEW SURVEY ON CHRONIC PAIN

Pain Alliance Europe (PAE) , 2017

20%

• f the adult population in Europe (95 million),

suffers from chronic pain.

patients suffering from chronic pain describe their pain as ‘severe’

34%

• f the

patients who received traditional treatment, reported that it was not as effective as expected

78%

A survey on chronic pain, performed in 17 European countries (n=3490), indicates that approx.

• f the

DISADVANTAGES OF PAINKILLERS

In recent years there has been a push by regulatory agencies such as the FDA towards medical devices, characterized by less intensive side effects than painkillers, such as opioids.

• pioid prescriptions in the USA

in 2017

212

Americans died from opioid-related drug

• verdoses in the USA in 2017

50

million thousand

PROVEN RESULTS

SYSTEMATIC LITERATURE REVIEW

B-Cure Laser was cited in 4 out of 14 studies according to the systematic review published in the magazine "Photomedicine and Laser Surgery" (November 2018).

The systematic literature supports the

• utstanding efficacy of B-Cure Laser vs. all

medical photomedicine devices for home use worldwide, for the treatment of pain and wound healing.

• f the patients in the literature review

received B-Cure Laser therapy treatments

29%

Therapeutic efficacy of home-use photobiomodulation devices: a systematic literature review Gavish L., Faculty of Medicine, The Hebrew University of Jerusalem , Israel; Houreld N., Faculty of Health Sciences, University of Johannesburg, Johannesburg, South Africa

PROFESSIONAL RECOMMENDATIONS

International guidelines recommend the "use of low level laser therapy for treatment of Oral Mucositis" (November 2018) American College of Physicians’ guidelines include a “strong recommendation” for Low-Level Laser Therapy as a non invasive treatment for acute, subacute & chronic low back pain (April 2017) “We show that LLLT reduces pain immediately after treatment in acute neck pain and up to 22 weeks after completion of treatment in patients with chronic neck pain.” (December 2009)

B-CURE LASER’S EFFICACY IS ALMOST EQUIVALENT TO DRUG THERAPY

CLINICAL TRIAL OF 90 PATIENTS AFFECTED BY JOINT-RELATED PAIN (TMJ)

The mean VAS reduction of both the Laser group and the Drug group was almost equivalent and significant compared to the Placebo group. Published: CRANIO, April 2019

https://www.ncbi.nlm.nih.gov/pubmed/30999823

Del Vecchio A., Fioravanti M., Boccassini A., Di Paolo C., Romeo U. Department of Oral and Maxillo Facial Sciences | Sapienza University of Rome, Italy

B-CURE LASER’S CLINICAL TRIALS

B-Cure Laser’s efficacy for the treatment

• f pain and wounds has been

proven in 5 double blind clinical trials. 5 other clinical trials are in process.

For more details see Appendix 1

Joint-Related Pain (TMJ) Sapienza University Italy Laminectomy Sao Paulo Hospital Brazil Diabetic Wounds Hadassah Medical Center Israel Dental Implantation PERM University Russia Joint-Related Pain (TMJ) University of Parma Italy

PROVEN EFFICACY SAFE INNOVATION PROFIT STRONG IP

For treating pain,

• rthopedic conditions,

inflammation, sports injuries and wounds. For use by all family members of all ages, without the need for protective goggles. International breakthrough, very large coherent laser beam with a treatment area of 4.5cm2. The B-Cure laser technology offers high potential profit for our distributors and benefits to our patients. Which surpasses competitors through advanced technology. Registered patents.

B-CURE LASER BENEFITS

MORE THAN

DEVICES SOLD

(correct May 2020)

MARKET SURVEY SHOWS SIGNIFICANT DECREASE IN INTOLERABLE PAIN

10,000

A sample of 300 B-Cure Laser patients were randomly selected out of B-Cure Laser patients, to participate in an independent market survey.

76% 59%

Geocartography Knowledge Group Analysis by L. Gavish, Faculty of Medicine, The Hebrew University of Jerusalem, Israel

n=69

Intolerable pain (Pain NRS = 8-10)

n=177 n=69

60% of the patients who had suffered intolerable pain (8-10 NRS),

experienced a significant pain decrease to bearable pain.

After treatment 69 patients (23%) considered themselves as suffering intolerable pain. Before treatment 177 patients (59%) considered themselves as suffering intolerable pain.

• f the patients were satisfied with the device.

Analysis by Dr. L. Gavish, The Hebrew University of Jerusalem, Israel, August 2017, Israel

70%

RECOGNITION

“I can definitely say it was one

• f the best decisions I’ve made

in my life. I used the device two-three times a day and within a few days the pain decreased significantly. From not being able to move my arm, I quickly managed to make movements and return to training. B-Cure Laser Sport helped me return to routine faster than the “usual recovery” applying my standard care treatments. surprising even my doctors. I started training again very quickly."

JUDO DE FEMME NUMÉRO 1 MONDIAL

AGBEGNENOU CLARISSE

PROFESSIONAL JUDO WORLD CHAMPION

AGBEGNENOU CLARISSE WOMEN JUDO WORLD CHAMPION (2014, 2017, 2018, 2019)

JUDO DE FEMME NUMÉRO 1 MONDIAL

AGBEGNENOU CLARISSE

STEFANO TACCONI FORMER JUVENTUS GOALKEEPER (1983-1992)

FOOTBALL UEFA CHAMPION

“A few months ago I heard about a device called B-Cure Laser Sport, which treats both the pain and the source of the problem with soft laser

• technology. What convinced me the most was

that the device was tested here in Italy and proved to be effective in a clinical trial. No side effects, short treatment time, and I could treat myself anywhere, at any time, at home and even while traveling. I began to treat myself with B-Cure Laser Sport and used it for the pains I had on both my legs and back. After several days of treatments at home I began to feel better - the pain decreased significantly and so did my mobility. I’m thrilled to recommend it to everyone, not

• nly to professional athletes like me, but to

anyone suffering from chronic pain, muscle aches, arthritis, orthopedic pain, and sport injuries."

“This device is amazing, helps me with my pain instantly. It is so quick and easy to use! Approved by my surgeon and physio so I have no worries. I hope to recover quicker due to this device. A massive thank you to B-Cure Laser for trusting me with your devices to try out. (They came all the way from Israel and personally handed to me) Also a big thank you to Yarden Gerbi who introduced me to the wonders of this device and the lovely people from the company"

JUDO DE FEMME NUMÉRO 1 MONDIAL

AGBEGNENOU CLARISSE

NEKODA DAVIS BRITISH DOUBLE WORLD MEDALIST (2017, 2018)

PROFESSIONAL JUDO WORLD MEDALIST

JUDO DE FEMME NUMÉRO 1 MONDIAL

AGBEGNENOU CLARISSE

GIUSTINO CERATOI OLIMPIA MILANO TRAINER

BASKETBALL ARMANI OLIMPIA MILANO

“I have received a recommendation for the B-Cure Laser Sport device from a colleague from another basketball team and treated athletes about three months ago for tendons in the knees, back, elbow, and epicondylitis, as well as chronic infections. My impression is very positive. To this day, I have used mainly expensive and stationary devices in the clinic which did not provide the availability and mobility of the B-Cure Laser Sport and this is, in my

• pinion, it’s the biggest advantage. An

athlete and basically any person suffering from pain can treat themselves before and after training or a competition, while traveling abroad or even at home. As soon as the athlete has been is injured, they can immediately start treating themselves and if they are suffering from chronic pain, the athlete can use the device two or even four times a day and can get faster healing results”.

INTERGRATION

The company already has integration in place in numerous medical institutes, such as:

• 1. The pain clinic in the Rambam Academic Hospital in Haifa, Israel
• 2. The Holy Family Hospital in Nazareth, Israel, where a current pilot is taking place

there in the pain clinic, orthopedic dept. and wounds clinic, with plans to extend to Oncology and children dept, when successful, might be integrated to the rest of the 250 hospitals worldwide managed by the " Hospitaller Order of the Brothers of Saint John of God".

• 3. The Scarborough And Rouge Hospital in Toronto Canada for the treatment of hard to

heal wounds and mucositis.

PROFESSIONAL RECOMMENDATIONS

“We highly recommend the B-Cure Laser Sport as part of an effective treatment for physical trauma, sports injuries and post-surgical

• recovery. The treatment with B-Cure

Laser has significantly reduced the use of anti-inflammatory medicines which are known to have many side effects." “B-Cure Laser Sport's exceptional efficacy has been proven by clinical trials and I highly recommend it as part of treatment protocols for the management of muscle strains and sport injuries." “After 4 years of experience with B-Cure Laser as a doctor I can highly recommend to use laser therapy for all sports injuries and also for Chronic pains of muscles and joints... The main advantage is that it is a home-based laser treatment." Richard Reff, MD. Board of Directors of the United States Olympic Committee Gavornikova Dagmar, MD. Chairman, Slovakian Olympic team

• Dr. Luba Galitskays,

Israeli Olympic team physician, Wingate Institute

THE CHOSEN OFFICIAL MEDICAL DEVICE

ISRAELI OLYMPIC DELEGATION RIO 2016 AND JAPAN 2020

“Due to the positive medical results in Rio 2016, and thereafter, the Israeli Olympic committee has decided to extend the cooperation, and the B-CURE LASER SPORT device will continue to be the official medical device for treating the Israeli Olympic Delegation to the Olympic Games in Japan 2020”. The Olympic Committee of Israel, Dec. 2018

VATICAN PHARMACY VATICAN CITY STATE

Serving an average of more than 2,000 clients a day, the Vatican Pharmacy may be one of the world’s busiest in-person dispensaries of pharmaceuticals,

• ver-the-counter medicines,

soaps, and elixirs. B-Cure Laser was successfully launched in the Vatican Pharmacy

• n April 2019

ISRAEL’S FLAGSHIP PRODUCT BEJING 2017

The B-Cure Laser device was chosen as 1 of 5 of the Israeli medical health flagship products to represent Israeli industry at the official government meeting in Beijing, marking 25 years of commercial relations with Beijing.

INNOVATION AWARD MEDICA

FIRST PLACE MEDICA 2014 INNOVATION AWARD FOR B-CURE LASER

B-CURE LASER GRANTED PATENTS

PATENTS Patents have been granted in numerous targeted countries including the USA, most EU countries, Canada, Brazil, India, Japan, China, S. Africa and Israel. A NEW PATENTED CATEGORY IN LLLT The patented laser beam covers a coherent area of 4.5 cm² allowing the free flow of the laser beam. NO PROTECTIVE GOGGLES NEEDED Due to its innovative electro-optic mechanism − the wide energy distribution enables use of the B-Cure Laser device, without requiring protective goggles for eye-safety.

250 mW 808 nM

B-CURE LASER OUR HORIZON

The present is ours to share now. With new products and services in our pipeline, we continue to blend our innovative technology with true caring, striving towards a better future. Good Energies make wonderful things happen, for all involved.

B-CURE LASER SUMMARY

PROVEN EFFICACY

The B-Cure Laser's efficacy has the most and best clinical evidence of all portable devices for home use worldwide, for the treatment of pain and wounds.

CLINICALY PROVEN

It's efficacy is supported by 5 double blind clinical trials from 4 different countries.

GLOBAL RECOGNITION

B-Cure Laser efficacy is supported by a Systematic Literature Review from the American medical magazine "Photomedicine and Laser Surgery". B-Cure Laser is cited 4 times out of 14.

POST MARKETING SURVEY

79% of the patients

were satisfied with the device.

60% of the patients who had suffered intolerable pain, experienced a significant pain decrease to bearable pain.

ADVANTAGES

The treatment area, safe, No known side-effects, with long lasting results, non-invasive, time saver, advanced technology, no protective goggles needed, easy and user friendly, highly cost effective.

+ + + +

B-CURE LASER - A MUST-HAVE IN EVERY HOME

We invite you to join our team and actively contribute to our vision

• f filling our world with

Good Energies….

THANK YOU

APPENDIX 1

GLOBAL RECOGNITON AND CLINICAL TRIALS

GLOBAL RECOGNITION ORAL MUCOSITIS GUIDELINES

The Multinational Association of Supportive Care in Cancer (MASCC) and the International Society of Oral Oncology (ISOO) have published guidelines that show evidence- based recommendations for low-level laser therapy for treating and preventing oral mucositis caused by radiotherapy or chemotherapy (November, 2018).

Abstract source: https://www.mascc.org/mucositis-guidelines

GLOBAL RECOGNITION LOW BACK PAIN GUIDELINES

American College of Physicians' guidelines include a “strong recommendation” for Low Level Laser Therapy as a non-invasive treatment for acute, subacute & chronic low back pain. (April 2017)

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term=28 192789

GLOBAL RECOGNITION NECK PAIN, SYSTEMATIC REVIEW

“We show that LLLT reduces pain immediately after treatment in acute neck pain and up to 22 weeks after completion of treatment in patients with chronic neck pain.” (December 2009)

Source: Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomized placebo or active- treatment controlled trials. THE LANCET, Volume 374, No. 9705, p.1897–1908, 5 December 2009

CLINICAL TRIALS JOINT-RELATED PAIN

CLINICAL TRIAL OF 90 PATIENTS AFFECTED BY JOINT-RELATED PAIN (TMJ) The Efficacy of B-CURE LASER is almost equivalent to conventional drug therapy The Mean VAS reduction of both the Laser group and the Drug group was almost equivalent and significant compared to the Placebo group.

Published: CRANIO, April 2019 https://www.ncbi.nlm.nih.gov/pubmed/30999823 B-Cure Laser: A new home protocol of lllt in patients affected by joint-related pain (TMJ) Del Vecchio A., Fioravanti M., Boccassini A., Di Paolo C., Romeo U. Department of Oral and Maxillo Facial Sciences | Sapienza University of Rome, Italy

CLINICAL TRIALS LAMINECTOMY

B-Cure Laser, in comparison with the placebo group, stimulates better wound healing and significantly reduces pain level, inflammation and drainage output.

Abstract published in: American Society for Laser Medicine and Surgery 2014 (Submission in process) * Graph 8. Visual Analogue Scale (VAS) (24h p = 0.0001) (72h p = 0.0001) B-Cure Laser: Low Level Laser Therapy prevents complications post laminectomy Holanda V., Pereira B., Ferreira K., Greiffo F., Oliveira J., Franca C., Silva D., Ontaneda M., Pinto N., Chavantes C. Beneficência of Sao Paulo Hospital, Sao Paulo, Brazil

CLINICAL TRIALS DIABETIC FOOT ULCERS

12 weeks of daily B-Cure Laser Pro treatments significantly decreased wound size in patients with diabetic foot ulcers compared to the sham laser group. 7 of 10 active patients vs. 1 of 9 placebo patients had >90% wound closure (p=0.019).

Abstract Published in: 37th Annual Meeting of the Israel Orthopedic Association, Dec. 2017, Tel Aviv, Israel. (Submission in process)

B-Cure Laser Placebo

% Wound Closure (Mean SEM) (p=0.033)

Healing of chronic diabetic foot ulcer using B-Cure Laser Pro Haze A., Elishoov O., Liebergall M. The Division of Orthopedics Hadassah Medical Center, Jerusalem, Israel

CLINICAL TRIALS DENTAL IMPLANTATION

The use of B-Cure Laser in prevention and treatment regimens before and after Dental Implantation significantly reduces the frequency and intensity of pain symptoms and oral mucosal postoperative hematomas compared to the sham laser group.

Published in: Physics of Cancer: Interdisciplinary Problems and Clinical Applications, Sep 2017

B-Cure Laser (n=15) Placebo (n=15)

B-Cure Laser Pro technology for preventing and treatment of peri-implant mucosits Gileva O., Libik T., Chuprakov M., Yakov A. Department of Therapeutic and Preclinic Dentistry, Perm, Russia

CLINICAL TRIALS JOINT-RELATED PAIN

B-Cure Laser group experienced a 50% decrease in pain level within two weeks compared to 8% in the sham laser group.

Published in: The “Laser Therapy”, March 2015 B-Cure Laser: The “at home LLLT” in joint-related pain control (TMJ): a pilot study Fornaini C., Pelosi A., Queirolo V., Vescovi P. and Merigo E. Department of Biomedical, Biotechnological and Translational Sciences, University of Parma, Italy

(n=12) (n=12)