Detecting(Vaginitis at(the Point/of/Care in(90 (Seconds - - PowerPoint PPT Presentation
Detecting(Vaginitis at(the Point/of/Care in(90 (Seconds EXCLUSIVE(DISTRIBUTOR( www.threea.az ! Exclusive+Distributor ! ThreeA Ltd.,+a+consulting+company++established+by+experts+in+
! ThreeA Ltd.,+a+consulting+company++established+by+experts+in+ 2011+in+Baku,+Azerbaijan,+and+with+the+purpose+to+act+in+ strategic+markets+both+in+local+and+international+arena. ! We+analyze+and+understand+business+needs+and+try+to+ bridge+the+gap+between+the+current+market+practices+and+ world+standards+by+providing+comprehensive+collaborative+ services+through+our+partners.+ ! ThreeA Ltd.+is+the+exclusive+distributor+of+3QBD+in+ Azerbaijan.+
3
Quick,+Qualified+and+Quality+Bio+Diagnostics. 3QBD+is+a+startHup+company+providing+health+solutions. Founded+by+two+wellHknown+analytical+chemists+,+Dr. Avraham+ Lorber &+Dr. Zeev Karpas,+each+with+over+30+years+ experience+in+the+field+of+analytical+chemistry. § 3QBD+has+developed+a+platform+based+on+molecular+ diagnostic+technology+with+applications+in+gynaecology,+ infectious+diseases,+food+freshness+and+veterinary+medicine.
Bringing&Proven&Technology& to&Vaginal&Infection&Diagnosis! ! Based+on+worldHproven+Ion+Mobility+Spectrometry+(IMS)+ technology,+3QBD's+patented+VGTest device+will+transform+ the+field+of+gynecological+diagnosis+and+treatment,+allowing+ physicians+to+upgrade+the+care+their+patients+now+receive.+ ! The+device+is+easy+and+quick+to+operate,+requiring+simply+a+ swab+of+vaginal+fluid+which+the+doctor+then+inserts+into+the+ VGTest device.+Within+one+minute,+the+device+will+detect+ whether+an+infection+is+indeed+present,+and+if+so,+classify+it+as+ vaginosis,+candidiasis+(late+2010)+or+trichomoniasis.+
Vaginitis An(inflammation of(the(vagina
microorganisms(– bacteria yeast(&(parasites
Discharge,(itching(and(pain
5
6
a(vaginal(complaint(have(vaginitis.
(BV) Candidiasis)(yeast(infectionor Trichomoniasis(parasitic(infection)
6
! Susceptibility to+HIV+&+other+STDs ! Transmission+to+sexual+partners ! Increased+miscarriage ! Preterm+deliveries ! Underweight+infants
8
VG&Test Laboratory&Test Gold&Standard AMSEL&Test
9
Amsel’s+criteria
! A+4/step(process.(Includes(subjective(tests. ! May(be(inaccurate(and(ineffective.(
The+Criteria+(3 of+ 4 & (
! Malodourous(thin(grey(vaginal(discharge. ! Vaginal(pH(>4.5. ! KOH(amine(whiff(test. ! Clue(cells(on(vaginal(smear(Gram(stain(( microscopy.
9
10
! Need(to(order(3(separate(tests. ! Takes(days,(delaying(treatment.( ! May(not(always(be(accurate. ! Revenue(goes(to(the(lab.
10
11
STEP+1+Take(sample
from(the(lateral(fornix
STEP+2+Apply(1(
drop(of(reagent
STEP+3+Insert(swab(
into(swab(housing
STEP+4+Insert(swab(
housing(into(the(VG(Test
STEP+5+Results(will(
show(in(90(seconds
11
12
13
Filter
13
14
Filter
14
15
Filter
15
16
0.2 0.4 0.6 0.8 1 6 7 8 9 10 11 12
Intensity((Volts) Drift(Time((ms) Amine(A Amine(B Amine(C Amine(D Before(Treatment After(Treatment
* Before treatment (high level of Amine A) * After treatment (normal level of Amine A)
16
17
! Technology+used+to+detect+chemical+and+biological+warfare+ agents+in+the+service+of+modern+medicine. ! A threeHstep+process.
18
! Biogenic+amines+concentration+in+ cells+is+tightly+regulated. ! Biogenic+amines+are+formed+by+ degradation+of+amino+acids+by+ micro+organisms+during+the+ necrosis+process. ! Among+those+compounds+are+ monoamines,+diamines and+ polyamines,+such+as:
Trimethylamine (TMA) Putrescine Cadaverine
19
! Elevated+levels+or+deficiency+cause+problems. ! May+serve+as+biochemical+markers+of+pathological+ conditions+such+as+infections+and+malignant+cell+ proliferation. ! A+good+correlation+was+found+between+vaginal+infections+ such+as+bacterial+vaginosis,+candidiasis+and+trichomoniasis and+the+types+and+quantities+of+biogenic+amines.
20
Security § Detection+of+explosives. § Detection+of+chemical+and+biological+warfare+agents. § Detection+of+illicit+drugs. Environmental+and+Safety § Detection+of+toxic+industrial+chemicals+in+air. Detection+of+contaminants+in+water+and+soil.
21
! Simultaneous&diagnosis+of+ the+three+ vaginal+infections. ! Simple+and+intuitive + to+use . ! Enables+immediate+ intervention .+ ! Cost+effective.
22
Sensitivity
Specificity
23
“We+are+able+to+detect+the+ 3+main+causes+for+vaginitis+&+ immediately+apply+the+bestH suited+treatment+to+our+ patients.” Dr.$Laksman,$Israel “VG+Test+offers+a+reliable+ diagnostic+tool+for+one+of+the+ most+common+and+poorly+ diagnosed+gynecologic+ problems.”$ Dr.$Seidman,$Israel “The+device+offers+us+ a+revolutionary+ method+of+diagnosis+
Prof.$Damiani,$Italy$$$ “Biogenic+testing+is+feasible+in+ amine+IMS+pointHofHcare+the+ ambulatory+care+setting.+ Dr.$Blankenstein,$Germany
24
"
Only+90 seconds&to+results
"
Clinically validated,+accurate
"
Easily&integrates&into+clinical+practice
"
Cost&effective
25
use
Infection& type& detection
makes& money
Test
Personal+ skills+ dependent
accurate
tests
Very& accurate&&& reproducible& results
in P
/Clinic
25
! This+would+be+really+helpful+in+the+acute+gynaecology+setting+and+I+ would+be+very+interested+in+trying+them. Consultant Obstetrics+&+Gynaecology ! I+would+support+the+use+of+bedside+tests+,+it+will+be+big+advantage.+ I+am+always+a+little+anxious+that+the+patient+may+have+her+HSG+ before+she+is+treated+for+infection.+It+would+also+make+life+easier+ with+fewer+reports+to+check+and+dictate. When+can+we+start? Consultant+Gynaecologist+ ! I+support+the+idea+of+bedside+testing+and+we+can+pilot+them+in+ GOPD,+urgent+gynae,+EPAU+and+fertility+clinics?+It+will+avoid+ writing+to+patients,+GPs+etc+and+save+a+lot+of+admin+time. Consultant+Obstetrician+and+Gynaecologist
! VHTest,+for+farm+animal+breedings+(Sows+&+Cows),+delivered in:+Q 2014 + 1 ! BioHTest,+for+food+freshness+testing+(beef,+chicken,+fish),+ delivered in:+Q 2014 + 2 ! VHTest+for+companion+animals+(dogs+&+cats(+delivered+in:+ Q4+2015 ! CHTest for+cancer+treatment+monitoring,+Biopsy+testing+and+ Cancer+monitoring, to+be+delivered+in+ + 2016
43+Zargarpalan street,+Baku,+Azerbaijan +994+12+409+19+46+ ++994+77+270+02+40+ info@threea.az www.threea.az