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D O - - PowerPoint PPT Presentation

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D O N O T C O

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  • Input

Output Something in the middle methi Outpu

The basal or ongoing state of the brain influences the outcome of stimulation

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  • 0·5mV

25 ms mulus

Modified from: Kobayashi & Pascual-Leone, 2003 (Lancet Neurology)

Intracortical Inhibition (ISI = 1-6ms) Intracortical Facilitation (ISI = 8-30ms) Test pulse (alone) Conditioning Pulse + Test Pulse

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  • Adaptation: Prolonged prior exposure to stimulus reduces

neural activity and response to subsequent presentation Priming: Transient prior exposure to stimulus increases neural activity and response to subsequent presentation

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  • Modified from: Silvanto et al., 2008 (Trends in Cognitive Sciences)

Baseline After adaptation to red After TMS Relative neural activity

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  • Cattaneo & Silvanto, 2008 (NeuroReport)

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  • Cattaneo et al., 2008 (European Journal of Neuroscience)

P P

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  • Fumiko Maeda · Julian P. Keenan · Jose M. Tormos

Helge Topka · Alvaro Pascual-Leone

Interindividual variability of the modulatory effects of repetitive transcranial magnetic stimulation on cortical excitability

Exp Brain Res (2000) 133:425–430 DOI 10.1007/s002210000432

R E S E A R C H A RT I C L E

240 pulses 1600 pulses

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80% 85% 90% 95% 100%

  • 70%

75% 80% 85% 90% 95% 100%

Baseline Post-rTMS

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  • Impact of 1Hz rTMS on Motor-Evoked Potential (MEP), Intracortical Facilatition and Inhibition
  • Fig. 1

Mean amplitude (±SD) of MEP to test stimulus alone after 1 Hz rTMS in migraineurs and controls (values are expressed as percentage of baseline MEP).

  • Fig. 2

Mean amplitude (±SE) of conditioned MEP at 2 and 10 ms ISI before and after rTMS in migraineurs and controls (values are expressed as percentage of changes from test stimulus alone). Brighina et al., 2005 (Experimental Brain Research)

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  • Siebner et al., 1999 (Neuroscience Letters)

Impact of 1Hz rTMS on Motor Evoked Potential (MEP) Area

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  • Iezzi E et al., 2008 (J Neurophysio)

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  • Siebner et al., 2004 (Journal of Neuroscience)

Impact of tDCS/rTMS on Motor-Evoked Potential (MEP) amplitude

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  • J Physiol 590.22 (2012) pp 5765–5781

5765

Homeostatic metaplasticity of corticospinal excitatory and intracortical inhibitory neural circuits in human motor cortex

Takenobu Murakami1, Florian M¨ uller-Dahlhaus1, Ming-Kuei Lu1,2 and Ulf Ziemann1,3

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  • Maeda et al., 2000 (Clinical Neurophysiology)

Impact of rTMS on Motor-Evoked Potentials Impact of daily 1Hz rTMS on visuo-spatial detection

Valero-Cabré et al., 2008 (European Journal of Neuroscience)

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  • Oberman et al., 2012 (European Journal of Neuroscience)

Impact of TBS on Motor-Evoked Potential (MEP) Amplitude

  • Oberman et al., (unpublished – do not share!)

Cumulative Impact of Back-to-Back TBS

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1

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  • 20

20 40 60 80 OHC DM2

MEP Amplitude (% ∆ from baseline)

All subjects

OHC DM2

BDNF Val/Met & ApoE ε3/ε4 excluded

p = 0.0537 Effect size = 0.35 p = 0.0051* Effect size = 0.52

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  • Ž

. Psychiatry Research: Neuroimaging Section 99 2000 161172

Left prefrontal activation predicts therapeutic effects of ž / repetitive transcranial magnetic stimulation rTMS in major depression

Gerhard Wilhelm Eschweiler, Christine Wegerer, Wilfried Schlotter, Christoph Spandl, Andreas Stevens, Mathias Bartels, Gerhard Buchkremer

Eberhard-Karls-UniersitatTubingen, Clinic of Psychiatry and Psychotherapy, Osianderstrasse 24, 72076 Tubingen, Germany

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