Compression Applicator and HDR 192 Ir Mark J Rivard, PhD, 1 Raymond J - PowerPoint PPT Presentation

Stereotactic Breast Brachytherapy Applied Peripherally Using a Compression Applicator and HDR 192 Ir Mark J Rivard, PhD, 1 Raymond J Bricault Jr., MSc, 2 Christopher S Melhus, MSc, 1 Jessica R Hiatt, MSc, 3 Piran Sioshansi, PhD, 2 and David E Wazer, MD, 1,3 1 Tufts-New England Medical Center, Boston, MA 2 Advanced Radiation Therapy, LLC, Billerica, MA 3 Rhode Island Hospital, Providence, RI s

Full Disclosure Rivard & Wazer are medical advisors to ART Bricault & Sioshansi are officers of ART AccuBoost is FDA approved only for breast brachytherapy

Treatment Process Overview

AccuBoost System: Equipment Integration computed radiography system mammography unit W-collimated applicators

Stereotactic Brachytherapy Image Guidance before alignment after alignment

Applicator: Mammography Paddle Interface compression paddle applicator alignment

AccuBoost Applicator Schematic

AccuBoost Irradiation Beam

Ionization Chamber & Film Measurements

Central Plane Dose: 5 cm Applicator

Central Plane Dose: 6 cm Applicator

Central Plane Dose: 7 cm Applicator

Depth Dose Profile: 6 cm Applicator

Monte Carlo Simulation Geometry cross-sectional view planar view through HDR dwells

Calculated AccuBoost Dose Profiles

Calculated Skin / Center Dose Ratio

Dosimetric Comparison

Summary • AccuBoost system integrates – mammography – computed radiography – externally-collimated HDR 192 Ir source for stereotactic breast brachytherapy • measured & simulated dosimetry: good agreement • forthcoming multi-institutional clinical use