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Clinical Research | Clinical Care Investigator Driven Industry Sponsored Breakfast-Wednesday April 06, 2016 Technology and Innovation Registries Colleen OConnell, MD FRCPC Research Chief Stan Cassidy Discoveries

  1. Clinical Research | Clinical Care • Investigator Driven • Industry Sponsored Breakfast-Wednesday April 06, 2016 • Technology and Innovation • Registries Colleen O’Connell, MD FRCPC Research Chief – Stan Cassidy • Discoveries Centre for Rehabilitation Assistant Professor – • Best Practice Dalhousie Faculty of Medicine/Memorial Development University

  2. Symbiotic Mutualism Breakfast-Wednesday April 06, 2016

  3. Clinical Research Breakfast-Wednesday April 06, 2016

  4. Practice-based Research • Research conducted by providers in clinical Breakfast-Wednesday April 06, 2016 practice • Final step in translational research continuum

  5. Patient-oriented • 17 pharmacologic trials – 3 investigator driven – >1M Breakfast-Wednesday April 06, 2016 – Current 11 staff PT funding (4 trials) • 9 technology trials – 100K CFI eksoskeleton – Biotone – 2.4M – Industry (Myndmove, Sensimat, B-Temia)

  6. Recent Grants - 2016 • ALS Discovery Grant – SCCR/Vitalite – 100K • ALS Clinical Management – SCCR/McGill – Breakfast-Wednesday April 06, 2016 200K + matching industry • RHSCIR - $40K • CFI – 100K • CNDR - $16K • Myndmove - $200K (4 sites)

  7. Outcomes and health services • Canadian ALS Registry Breakfast-Wednesday April 06, 2016 • Canadian NMD Registry • RHISCIR • > 250K to date • Knowledge Mobilization • 3 PT staff positions Network • ~ 55K annually

  8. Evidence Based Practice Breakfast-Wednesday April 06, 2016

  9. Epidemiological and behavioural • ALS-NB Cluster Study • ALS Quality of Life Breakfast-Wednesday April 06, 2016 Validation • ALS Research Readiness Summer research students • • Canadian ALS Registry National • presentations/publications • Canadian NMD Registry • RHISCIR

  10. Benefits to Patients and Systems • Improvements in Infrastructure: – Access to new equipment and technology – Access to novel therapies Breakfast-Wednesday April 06, 2016 – Acquisition of new skills • Improvement in Outcomes: – Greater adherence to treatment guidelines – More use of evidence-based practice • Staff attraction/retention • Improved research literacy • Culture of enquiry and critical appraisal of practice

  11. Canadian MS Survey Breakfast-Wednesday April 06, 2016

  12. New Brunswick Prevalence Multiple Sclerosis: 1300-1800 Amyotrophic Lateral Sclerosis: 60 patients Breakfast-Wednesday April 06, 2016 SCI – 30 new annually Muscular Dystrophy and related: 250 Parkinsons Disease, Huntingtons, Spinocerebellar Ataxias….

  13. Breakfast-Wednesday April 06, 2016

  14. Research Networks • Canadian ALS Clinical Trials and Research Network Breakfast-Wednesday April 06, 2016 • Rick Hansen Institute Spinal Cord Injury Research Leadership Team • SCI – Knowledge Mobilization Network • CCIC • Atlantic Mobility Action Project • End-MS Research Network • Canadian Neuromuscular Disease Research Network • Canadian Neuropulmonary Research Network

  15. Conclusion • Clinical research compliments clinical practice Breakfast-Wednesday April 06, 2016 • Creates jobs, brings in equipment, expertise and positive outcomes • Participation in national/international research networks and registries can facilitate participation and improve efficiencies

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