, , Chemodetection and Destruction of Host Urea Allows Helicobacter - PowerPoint PPT Presentation

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Chemodetection and Destruction of Host Urea Allows Helicobacter pylori to Locate the Epithelium, Huang et. al. Cell Host & Microbe, 18 , 135 (2015)

Multiple Acid Sensors Control Helicobacter pylori Colonization of the Stomach, Huang et. al. PLOS Pathogens, 13 (1): e1006118 (2017)

(A ) S till im ages o f bacterial m o tility traces (las ting 1.5 s eco nds ) o f P M S S 1 w ild-type (W T) H . pylo ri and Δ cheW H . pylo ri w ithin the field o f view 1.5 s eco nds befo re and 18 .5 s eco nds after expo s ure to a co m bined gradient o f 5 m M urea and 50 m M hydro chlo ric acid. The po s itio n o f the m icro injectio n needle tip is highlighted in yello w . (B ) S till im ages o f bacterial m o tility traces (las ting 1.5 s eco nds ) o f Δ tlpB H . pylo ri w ithin the field o f view 1.5 s eco nds befo re and 18 .5 s eco nds after expo s u re to a gradient o f 5 m M urea and 50 m M hydro chlo ric acid.

The ads o rptio n o f co liphage lam bda to its ho s t: E ffect o f variatio ns in the s urface dens ity o f recpeto r and in phage-recepto r affinity, S cw artz, J . M o l. B io l. 103, 521 (1976)

M eas u re o f the diffus ive lengths cale in a tim e t is given by the variance A s s um ing a diffus io n co ns tant o f D = 100 m m 2 /s , w e can es tim ate the tim e taken to explo re a cell o f s ize L thro ugh pas s ive diffus io n L Time 1 m m 0.01 s 10 m m 1 s 100 m m 100 s 1 m 10 10 s ~ 300 years

References and further reading