, , Chemodetection and Destruction of Host Urea Allows Helicobacter - - PowerPoint PPT Presentation

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Chemodetection and Destruction of Host Urea Allows Helicobacter pylori to Locate the Epithelium, Huang et. al. Cell Host & Microbe, 18, 135 (2015)

Multiple Acid Sensors Control Helicobacter pylori Colonization of the Stomach, Huang et. al. PLOS Pathogens, 13(1): e1006118 (2017)

(A ) S till im ages

• f bacterial

m

• tility traces

(las ting 1.5 s eco nds )

• f P

M S S 1 w ild-type (W T) H . pylo ri and Δ cheW H . pylo ri w ithin the field

• f view

1.5 s eco nds befo re and 18 .5 s eco nds after expo s ure to a co m bined gradient o f 5 m M urea and 50 m M hydro chlo ric acid. The po s itio n o f the m icro injectio n needle tip is highlighted in yello w . (B ) S till im ages

• f bacterial m
• tility

traces (las ting 1.5 s eco nds ) o f Δ tlpB H . pylo ri w ithin the field o f view 1.5 s eco nds befo re and 18 .5 s eco nds after expo s u re to a gradient o f 5 m M urea and 50 m M hydro chlo ric acid.

The ads

• rptio

n o f co liphage lam bda to its ho s t: E ffect o f variatio ns in the s urface dens ity o f recpeto r and in phage-recepto r affinity, S cw artz, J . M

• l. B

io

• l. 103, 521 (1976)

M eas u re o f the diffus ive lengths cale in a tim e t is given by the variance A s s um ing a diffus io n co ns tant o f D = 100 mm

2/s

, w e can es tim ate the tim e taken to explo re a cell o f s ize L thro ugh pas s ive diffus io n

L Time

1 mm 0.01 s 10 mm 1 s 100 mm 100 s 1 m 10

10 s

~ 300 years

References and further reading