CCLE Cancer Cell Line Encyclopedia Data 947 cancer cell lines - - PowerPoint PPT Presentation

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Aug 14, 2022 275 likes •409 views

CCLE Cancer Cell Line Encyclopedia Data 947 cancer cell lines with: 1600 genes from sequencing screen 392 common cancer genes mass specd mRNA expression drug-response profile of 24 compounds Clustering from Tuesday Dose-Response

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CCLE

Cancer Cell Line Encyclopedia

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Data

947 cancer cell lines with: ≈1600 genes from sequencing screen 392 common cancer genes mass spec’d mRNA expression drug-response profile of 24 compounds

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Clustering from Tuesday

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Dose-Response Curves

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Drug Response Prediction

Input: A feature vector for each gene, (mutation value, GISTIC results, “pathway activity score”) Output: Predict a vector of dose-response statistics

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Naive Bayes

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Elastic Net

“It is like a stretchable fishing net that retains ‘all the big fish’” Uses L1 and L2 regularization

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Elastic Net (cont.)

Good when p>>n

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Results

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Results (cont.)

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Proof of Concept with AHR

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