CardioSolutions Mitra-Spacer TM A Novel Approach to Mitral - - PowerPoint PPT Presentation

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Dec 11, 2022 661 likes •828 views

CardioSolutions Mitra-Spacer TM A Novel Approach to Mitral Regurgitation Jian Ye, MD, FRCSC Division of Cardiac Surgery St. Pauls Hospital University of British Columbia Vancouver, Canada Disclosure Statement of Financial Interest I, Jian Ye

SLIDE 1

Jian Ye, MD, FRCSC

Division of Cardiac Surgery

St. Paul’s Hospital

University of British Columbia Vancouver, Canada

CardioSolutions Mitra-SpacerTM

A Novel Approach to Mitral Regurgitation

SLIDE 2

Disclosure Statement of Financial Interest

I, Jian Ye, DO NOT have a financial interest/arrangement or affiliation with one

r more organizations that could be

perceived as a real or apparent conflict of interest in the context of the subject of this presentation.

SLIDE 3

Minimally-Invasive MV Repair Technologies

Leaflet Coaptation

 Edge-to-Edge Repair  Alfieri Stitch

Annular Reshaping

 Cinching  Annuloplasty

SLIDE 4

Cardiosolutions Mitra-SpacerTM

SLIDE 5

In Vitro Study

Cardiosolutions Spacer Boundary Condition Characterization

SLIDE 6

In Vitro Study

Cardiosolutions Spacer Boundary Condition Characterization

SLIDE 7

Acute and Chronic Animal Study

Transapical Approach

SLIDE 8

Chronic Animal Study

Patchy mild granularity of surface of anterior leaflet (predominately affecting A2 and A3), and mild endocardial fibrosis of the left atrium above P3 after 391 days

Anter ior Leafl et Poste rior Leafl et

P 1 P 2 P 3 A 1 A 2 A 3

SLIDE 9

Percutaneous approach (acute study)

Figure 7. Implant deployed Apex of LV Left atrium Balloon spacer Anchor hooks deployed into tissue Cusps of mitral valve

Clinical Feasibility Study

SLIDE 10

Before the Spacer After the Spacer

Clinical Feasibility Study

Percutaneous Approach (acute study)

SLIDE 11

Transapical Approach (acute study)

Clinical Feasibility Study

SLIDE 12

Transapical Approach (acute study)

Before Mitra-Spacer After

Clinical Feasibility Study

SLIDE 13

Potential Advantages of Mitra-Spacer™

Safe, fast, intuitive procedure
Small access portals
Percutaneous or transapical approaches
No change in the native mitral valve and heart

anatomy after short-term implantation

Minimal alterations in mitral structure following

long-term implantation – does not preclude patients from subsequent surgical MV repair

SLIDE 14

Potential Indications

Functional MR
High surgical risk patients with either

functional or structural MR Long term or bridge therapy

Non-surgical patients with either functional
r structural MR

Long term therapy (Permanent solution?)

MR patients undergoing other transcatheter

procedures

TAVR: patient with AS and MR
PCI: patient with CAD and MR

SLIDE 15