CAMDA: An Overview Michael Ochs Bioinformatics Fox Chase Cancer - PowerPoint PPT Presentation

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CAMDA: An Overview Michael Ochs Bioinformatics Fox Chase Cancer Center Bioinformatics Fox Chase Cancer Center CAMDA 00 800 genes 70 conditions 7000 genes 38 conditions Bioinformatics Fox Chase Cancer Center Lessons 1 One Gene Does

CAMDA: An Overview Michael Ochs Bioinformatics Fox Chase Cancer Center
Bioinformatics Fox Chase Cancer Center
CAMDA 00 800 genes 70 conditions 7000 genes 38 conditions Bioinformatics Fox Chase Cancer Center
Lessons 1 • One Gene Does Not a Discriminator Make • AML/ALL Can Be Distinguished by … • If you have one really easy data set … Bioinformatics Fox Chase Cancer Center
CAMDA 00 Winner Greg Grant, E. Manduc h i, and Chris Stoec k e rt, Computati o nal B iol ogy and Infor mati c s L aboratory (C BIL), Uni v er s i ty o f Penn s y lvania Using non-p arametric method s in the cont ext o f multiple testi n g to determine dif fere n tially ex p ressed genes. Bioinformatics Fox Chase Cancer Center
CAMDA 01 1400 genes 60 conditions 6000 genes 300 conditions 4x Bioinformatics Fox Chase Cancer Center
Lessons 2 • A Little Biology Goes a Long Way • Those Two Cell Lines are Wrongly Classified • How many Patterns/Clusters/Groups?? Bioinformatics Fox Chase Cancer Center
Winner 01 Kevin R . Coombes , Keith A. Baggerl y , David N. Sti v er s , J ing Wang, Davi d Gold, H i s -Guan Sung, Sang- J oon Lee , Ander s o n Can c er C enter. Biology- D riven C lustering o f Microarray Data: App lica tions t o t h e NCI60 D ata Set Bioinformatics Fox Chase Cancer Center
CAMDA 02 12000 genes 14 conditions 6000 genes 18 conditions 4x Bioinformatics Fox Chase Cancer Center
Lessons 3 • Even Affy Mislabels • Why Are There Mismatch Pairs? • Does Gene Ontology Really Need to be Used to Identify Mistakes? Bioinformatics Fox Chase Cancer Center
Winner 02 Stivers, D ., Wang J., R osner, G., Coombes, K.ÊÊ Ê ÊÊÊÊ Ê ÊÊÊ UT M.D. Anders o n Can c er C enter Hou s ton, TX Org a n -Specific D ifferences in Gene Ex pression and UniGene Anno tation s D escribing Sou rce Material Bioinformatics Fox Chase Cancer Center
CAMDA 03 12000 genes 30000 genes 186 conditions 96 conditions 19000 genes 24000 genes 39 conditions 67 conditions Bioinformatics Fox Chase Cancer Center
Lessons 4 Time for Biology and Medicine Bioinformatics Fox Chase Cancer Center
Winner 03 … right after Bioinformatics Fox Chase Cancer Center

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