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Bioinformatics Fox Chase Cancer Center
Bioinformatics Fox Chase Cancer Center
CAMDA: An Overview Michael Ochs Bioinformatics Fox Chase Cancer - - PowerPoint PPT Presentation
CAMDA: An Overview Michael Ochs Bioinformatics Fox Chase Cancer - - PowerPoint PPT Presentation
CAMDA: An Overview Michael Ochs Bioinformatics Fox Chase Cancer Center Bioinformatics Fox Chase Cancer Center CAMDA 00 800 genes 70 conditions 7000 genes 38 conditions Bioinformatics Fox Chase Cancer Center Lessons 1 One Gene Does
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Bioinformatics Fox Chase Cancer Center
CAMDA 00
800 genes 70 conditions 7000 genes 38 conditions
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Bioinformatics Fox Chase Cancer Center
Lessons 1
- One Gene Does Not a Discriminator
Make
- AML/ALL Can Be Distinguished by …
- If you have one really easy data set …
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Bioinformatics Fox Chase Cancer Center
CAMDA 00 Winner
Greg Grant, E. Manduc h i, and Chris Stoec k e rt, Computati o nal B iol
- gy and
Infor mati c s L aboratory (C BIL), Uni v er s i ty o f Penn s y lvania Using non-p arametric method s in the cont ext o f multiple testi n g to determine dif fere n tially ex p ressed genes.
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Bioinformatics Fox Chase Cancer Center
CAMDA 01
1400 genes 60 conditions 6000 genes 300 conditions 4x
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Bioinformatics Fox Chase Cancer Center
Lessons 2
- A Little Biology Goes a Long Way
- Those Two Cell Lines are Wrongly
Classified
- How many Patterns/Clusters/Groups??
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Bioinformatics Fox Chase Cancer Center
Winner 01
Kevin R . Coombes , Keith A. Baggerl y , David N. Sti v er s , J ing Wang, Davi d Gold, H i s
- Guan
Sung, Sang- J
- on Lee ,
Ander s o n Can c er C enter. Biology- D riven C lustering o f Microarray Data: App lica tions t o t h e NCI60 D ata Set
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Bioinformatics Fox Chase Cancer Center
CAMDA 02
12000 genes 14 conditions 6000 genes 18 conditions 4x
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Bioinformatics Fox Chase Cancer Center
Lessons 3
- Even Affy Mislabels
- Why Are There Mismatch Pairs?
- Does Gene Ontology Really Need to be
Used to Identify Mistakes?
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Bioinformatics Fox Chase Cancer Center
Winner 02
Stivers, D ., Wang J., R
- sner, G.,
Coombes, K.ÊÊ Ê ÊÊÊÊ Ê ÊÊÊ UT M.D. Anders o n Can c er C enter Hou s ton, TX Org a n
- Specific D
ifferences in Gene Ex pression and UniGene Anno tation s D escribing Sou rce Material
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Bioinformatics Fox Chase Cancer Center
CAMDA 03
12000 genes 186 conditions 30000 genes 96 conditions 19000 genes 39 conditions 24000 genes 67 conditions
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Bioinformatics Fox Chase Cancer Center
Lessons 4
Time for Biology and Medicine
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Bioinformatics Fox Chase Cancer Center