Biomaterials: biological origin or application? Andrs Vercik Grupo - - PowerPoint PPT Presentation

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Biomaterials: biological origin or application? Andrs Vercik Grupo - - PowerPoint PPT Presentation

Biomaterials: biological origin or application? Andrs Vercik Grupo de Nanotecnologia, Biomateriais e Dispositivos (www.usp.br\nanobiodev) Faculdade de Zootecnia e Engenharia de Alimentos Universidade de So Paulo Biomaterials: biological


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Biomaterials: biological

  • rigin or application?

Andrés Vercik Grupo de Nanotecnologia, Biomateriais e Dispositivos (www.usp.br\nanobiodev) Faculdade de Zootecnia e Engenharia de Alimentos Universidade de São Paulo

Biomaterials: biological origin or application?

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Motivation

Biomaterials: biological origin or application?

Science Accuracy Precision Concept Words Terms Names

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Example: Stent

  • Intravascular stent
  • Stented heart valve
  • Stent-graft
  • Stent-valve

Biomaterials: biological origin or application?

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Example: dislocation

Biomaterials: biological origin or application?

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Roots: multiple meanings

nano

  • Nanotechnology
  • Nanostructure
  • Nanomaterials

Nanostructured material

Bio

  • Biopolymers
  • Bioceramics
  • Biomaterials
  • Biomedical materials

Biomaterials: biological origin or application?

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XII SBPMat – Symposium H

Sym posium H

New Trends in Biom aterials and Nanom aterials Applied to Biosystem s Scope: The symposium will provide a platform for discussing current advancements and future trends in biomaterials for biomedical and dental applications and nanomaterials applied to biosystems. Through the synergistic approach of applied chemistry and physics, material science, electronics, mechanical engineering, biochemistry and medicine, this symposium about biomaterials includes how the deeper insight into biological events and its interplay with nanotechnology may support the development of a generation of novel materials, micro-nano-devices and molecular level approaches suited to solve relevant biomedical problems both for therapy and diagnostics. New materials also play an important role in veterinary, agriculture, biotechnology, smart packaging, food industry and natural environment. The subject matter of the symposium reflects the wide range and transdisciplinary nature of research in materials science and engineering applied to biological systems. The symposium will provide an excellent opportunity to meet and establish collaboration with large number of experts with several specializations including engineering, basic sciences, pharmacists, medical and dental professionals, etc. Session Topics: Biomaterials in constructing tissue substitutes Synthetic scaffolds as extracellular matrices Bioinspired and biomimetic materials Anti-infective biomaterials Adhesive biomaterials Biomaterials for cardiovascular applications, vascular grafts and embolic devices Biomaterials for cancer therapy Biomaterials for orthopedic and ophthalmic applications Controlled Release Biomaterials in dental applications Materials applied to Agriculture, smart packaging Biodegradable Polymers, Polymers from Renewable Resources and Hydrogels Nanotoxicology and Nanoecotoxicology Sensors and Biosensors Tentative List I nvited Speakers: Mitsuo Niinomi, Institute for Materials Research Biomaterials Science, Japan Thierry Gloriant, Institut National des Sciences Appliquées - INSA, France Yannis Missirlis, University of Patras, Laboratory of Biomechanics and Biomedical Engineering, Greece Garrett B. McGuinness, Dublin City University, Centre for Medical Engineering, Research, Ireland Ketul C. Popat, Colorado State University, USA Pedro L. Granja, Instituto de Ciências Biomédicas, Portugal Jonny Blake, Imperial College, UK Alexander L. Yarin, University of Illinois, USA Sym posium organizers: ú ú tá é dow nload

Biomaterials: biological origin or application?

Different Words Same Phenomena

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Biomaterials: biological origin or application?

Biomaterials Biomaterials Biomaterials

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Talk outline

  • Definitions of bio-things
  • Examples of bio-things (to make us change our minds)
  • Let’s try a new definition?
  • Rules of the game

Biomaterials: biological origin or application?

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Accuracy - Definitions

Biosensor (IUPAC 1999)

“a self-contained integrated device, which is capable of providing specific quantitative or semi-quantitative analytical information using a biological recognition element (biochemical receptor) which is retained in direct spatial contact with an electrochemical transduction element”

  • D. R. Thévenot et al. Pure Appl. Chem., Vol. 71, No.

12, pp. 2333-2348, 1999.

Biomaterials (Williams 1999)

“a material intended to interface with biological system to evaluate, treat, augment or replace any tissue, organ, or function of the body”

The Williams dictionary of biomaterials. University Press, 1999.

Biomaterials: biological origin or application?

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Accuracy - Definitions

Biosensor Biomaterials

Biomaterials: biological origin or application?

Biological Element Transducer Sense

Biological System Material Evaluate Treat Augment Replace

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Accuracy - Definitions

Biosensor (IUPAC 1999)

“a self-contained integrated device, which is capable of providing specific quantitative or semi-quantitative analytical information using a biological recognition element (biochemical receptor) which is retained in direct spatial contact with an electrochemical transduction element”

  • D. R. Thévenot et al. Pure Appl. Chem., Vol. 71, No.

12, pp. 2333-2348, 1999.

Biomaterials (Williams 2009)

“a substance that has been engineered to take a form which, alone or as part of a complex system, is used to direct, by control of interactions with components of living systems, the course of any therapeutic or diagnosis procedure, in human or veterinary medicine”

  • D. F. Williams, Biomaterials 30 (2009) 5897-5909.

Biomaterials: biological origin or application?

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Concept of Biological System (element)

Biomaterials community vision There are many more living things

Biomaterials: biological origin or application?

1999 1999 2009

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Is it a biomaterial?

  • Titanium
  • Steel
  • Silicon
  • Gold
  • Silver
  • Collagen
  • Cellulose
  • Gelatin
  • Chitosan
  • Wood

Biomaterials: biological origin or application?

Application? Origin?

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Neurons on silicon

Nanoelectronic scaffolds Is it a biomaterial?

Scaffold Yes Biosensor No

Biomaterials: biological origin or application?

  • B. Tian et al., Nature Materials 11 (2012) 986-994
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Energy harvesting

Biomaterials: biological origin or application?

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Biofuel cell

Biomaterials: biological origin or application?

  • A. Zebda et al., Nature Communications DoI: 10.1038/1365.
  • A. Zebda et al., Scientific Reports 3: 1516 (2013) 1-5
  • D. Leech et al., Electrochimica

Acta 84 (2012) 223–234

  • M. Holzinger et al.,

Electrochimica Acta 82 (2012) 179–190

  • J. Ma, Y. Sahai / Carbohydrate Polymers 92 (2013) 955–975
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Biodegradable electronics

Biomaterials: biological origin or application?

  • M. Irimia-Vladu et al., Materials today 15 (2012) 340-346.
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Theragnostics

Biomaterials: biological origin or application?

  • P. Rai et al., Advanced Drug Delivery Reviews 62 (2010) 1094–1124
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Is it a biomaterial?

Biomaterial (Natural or synthetic)

  • Titanium
  • Steel
  • Silicon
  • Gold
  • Silver

Natural Material

  • Collagen
  • Cellulose
  • Gelatin
  • Chitosan
  • Wood

Biomaterials: biological origin or application?

Application? Origin?

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Is it a biomaterial?

Yes Application No Origin

Biomaterials: biological origin or application?

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Let’s try a definition

  • a substance that has been engineered
  • alone or as part of a complex system
  • is used to do something (direct…)
  • control of interactions with components of living systems
  • therapeutic or diagnosis procedure, in human or

veterinary medicine

  • Intended to work in intimate spatial contact with a

biological system

Biomaterials: biological origin or application?

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Biomaterial

“a material intended to interface with a biological system”

Biomaterials: biological origin or application?

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Biomaterial

“an engineered substance that, alone or as part

  • f a complex system, is devised to interface (or

to work) in intimate (spatial) contact with a biological system, by controlling their (mutual) interactions”

Biomaterials: biological origin or application?

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Interactions

Material on biology

  • Toxicity
  • Rejection
  • Necropsy
  • Induction
  • Activity

Biology on material

  • Cell or protein adhesion
  • Corrosion
  • Interference

Biomaterials: biological origin or application?

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Rules of the game: Foul

Yes! No!

Biomaterials: biological origin or application?

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Biomaterials: biological origin or application?

Thank you!

When I use a word, it means what I choose it to mean, neither more nor less