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- Dr. Trevor Mundel
President, Global Health Program
Bill & Melinda Gates Foundations Global Health Program Dr. - - PowerPoint PPT Presentation
Bill & Melinda Gates Foundations Global Health Program Dr. - - PowerPoint PPT Presentation
Bill & Melinda Gates Foundations Global Health Program Dr. Trevor Mundel President, Global Health Program EVERY PERSON DESERVES THE CHANCE TO LIVE A HEALTHY, PRODUCTIVE LIFE. Our Approach to Global Health Our Global Health program
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Our Approach to Global Health
Our Global Health program aims to harness advances in science and technology to save lives in developing countries.
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Our Global Health program aims to harness advances
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MenAfriVac Delivery and Impact
- Dramatic reduction in
reported meningitis cases in “epidemic districts”
- Disappearance of
Group A meningitis
- Stable fraction of
non Group A meningococcal isolates
- Absence of Group A
in carriage studies
2010 ~ 20 Million vaccinated 2011 ~ 35 Million vaccinated 2012 ~ 55 Million to be vaccinated
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Saving Lives Today
2006 2007 2008 2009 2011
Meningitis Epidemic Curve 1997-2011 (Burkina Faso data)
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Portfolio Matrix Portfolio Matrix
DOLLARS PER DALY AVERTED PROBABILITY OF SUCCESS (PTRS)
$1 $10 $100 $1K $10K $100K $1M 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
100 Million DALYs Averted
Surgical Male Circumcision Pox Protein Passive Immunizations TMC278LA Dapivirine Ring REMox PaMZ DS PaMZ MDR Novel-2 Aeras402 Aeras485 M72 M72 M72 Tafenoquine GNF 156 NITD 609 OZ 439 RTS,s RTS,s 2nd Gen LIQ PCV (SII) WC CP NRRV HPV Vx Flubendazole Anti-Wolbachia Shigella CP Anti-Secretory Leish F3 116E Liquid Hookworm
TB Malaria HIV/AIDS Pneumonia EDD NID
Bed Nets
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Translational 10X
PROBABILITY OF SUCCESS (PTRS)
100% 80% 60% 40% 20% 100 M 10 M 1 M
Cost
Reduced Investment at Risk
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Leveraging Biotech Energy for Next-Generation Malaria Vaccine
- Rapid (<2 wk)
- Comprehensive
- Unbiased plasmablast-based Ab evolution
- Diversification profiling
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