Bile acids: The Enigma of Emulsification --- UHCW 1 Emulsifying - - PowerPoint PPT Presentation

▶
bile acids the enigma of emulsification
SMART_READER_LITE
LIVE PREVIEW

Bile acids: The Enigma of Emulsification --- UHCW 1 Emulsifying - - PowerPoint PPT Presentation

Jul 26, 2023 259 likes •385 views

Getting Fat & Water to mix--- Bile acids: The Enigma of Emulsification --- UHCW 1 Emulsifying fat-- Toluene: stained with Sudan Red to show the oil layer Toluene- SR Water Gift from Prof. Charles Stirling FRS UHCW 2 Emulsifying fat--

slide-1
SLIDE 1

UHCW 1

Bile acids: The Enigma of Emulsification ---

Getting Fat & Water to mix---

slide-2
SLIDE 2

UHCW 2

Emulsifying fat-- Gift from Prof. Charles Stirling FRS Toluene-SR Water Toluene: stained with Sudan Red to show the oil layer

slide-3
SLIDE 3

UHCW 3

Emulsifying fat-- Gift from Prof. Charles Stirling FRS Toluene: stained with Sudan Red to show the oil layer Toluene-SR Water Toluene-SR Water Stearic acid

slide-4
SLIDE 4

UHCW 4

Gift from Prof. Charles Stirling FRS Toluene: stained with Sudan Red to show the oil layer

Emulsifying fat--

Toluene-SR Water Cholic acid Toluene-SR Water Toluene-SR Water Stearic acid

slide-5
SLIDE 5

UHCW 5

Gift from Prof. Charles Stirling FRS Toluene: stained with Sudan Red to show the oil layer

Emulsifying fat--

Toluene-SR Water Cholic acid Toluene-SR Water Toluene-SR Water Stearic acid Water Bile

Gift from Mr. Manfred Lambertz

slide-6
SLIDE 6

UHCW 6

Gift from Prof. Charles Stirling FRS Toluene: stained with Sudan Red to show the oil layer

Emulsifying fat--

Toluene-SR Water Cholic acid Toluene-SR Water Bile Toluene-SR Water Toluene-SR Water Stearic acid Water Bile

slide-7
SLIDE 7

UHCW 7

“Hydrophilic” surface “Hydrophobic” surface

  • -stays at the interface between water and air

Bile acids – and sailing boats??!!

slide-8
SLIDE 8

UHCW Gift from Prof K D Bardhan 8

BA in gut lumen: ~3g BA daily need: ~12-36g Fecal loss: ~600 mg daily

BA re-circulation

BA re-circulation 4-12 cycles / day

Bile acids: The journey

slide-9
SLIDE 9

UHCW Gift from Prof K D Bardhan & Dr M Smith 9

  • 95-98% absorbed in

terminal ileum

  • Recirculated up to

x 4-12 in 24 hours

BA

Bile acid absorption: In health

slide-10
SLIDE 10

UHCW 10

Watery diarrhea BA

  • TI absorption reduced
  • Excess unabsorbed BA spills into colon
  • Interferes with calcium-mediated water &

electrolyte absorption: Net fluid loss Bile acid absorption: In malabsorption

slide-11
SLIDE 11

UHCW Gift from Dr M Smith 11

Normal retention at day 7 : ≥ 15% SeHCAT Test procedure

  • Uncollimated gamma camera
  • 5 minute AP, PA views and background

The SeHCAT retention test